YOR310C / NOP58

Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOR310C / NOP58

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:6.46|P-value:8.75E-10 ID:SGTC_117|Compound:lucigenin|FD-Score:-4.72|P-value:5.19E-6 ID:SGTC_157|Compound:1348-1695|FD-Score:5.72|P-value:5.13E-8 ID:SGTC_197|Compound:4544-0043|FD-Score:5.86|P-value:2.43E-8 ID:SGTC_205|Compound:1486-1330|FD-Score:3.59|P-value:4.21E-4 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:3.39|P-value:7.97E-4 ID:SGTC_263|Compound:alizarin|FD-Score:5.82|P-value:2.99E-8 ID:SGTC_288|Compound:1315-0019|FD-Score:4.38|P-value:2.29E-5 ID:SGTC_339|Compound:3091-4833|FD-Score:3.92|P-value:1.33E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-3.96|P-value:1.06E-4 ID:SGTC_398|Compound:bronopol|FD-Score:-5.06|P-value:1.16E-6 ID:SGTC_530|Compound:4358-1714|FD-Score:4.06|P-value:8.07E-5 ID:SGTC_539|Compound:4859-0462|FD-Score:-8.29|P-value:4.90E-15 ID:SGTC_641|Compound:4092-0595|FD-Score:3.63|P-value:3.65E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:4.09|P-value:7.22E-5 ID:SGTC_959|Compound:1222-0044|FD-Score:3.49|P-value:5.84E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:7.10|P-value:1.84E-11 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:5.52|P-value:1.36E-7 ID:SGTC_1078|Compound:idebenone|FD-Score:5.48|P-value:1.71E-7 ID:SGTC_1080|Compound:nisoldipine|FD-Score:3.46|P-value:6.36E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-3.70|P-value:2.68E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:3.91|P-value:1.40E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:3.40|P-value:7.85E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:4.62|P-value:8.59E-6 ID:SGTC_1358|Compound:1509-0022|FD-Score:4.37|P-value:2.35E-5 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.87|P-value:1.56E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:-3.32|P-value:9.46E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.48|P-value:6.03E-4 ID:SGTC_1442|Compound:4112-3290|FD-Score:3.79|P-value:2.09E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:4.01|P-value:9.72E-5 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:6.29|P-value:2.40E-9 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:3.73|P-value:2.64E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:7.72|P-value:3.17E-13 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.61|P-value:8.31E-6 ID:SGTC_1741|Compound:st038134|FD-Score:4.01|P-value:9.43E-5 ID:SGTC_1748|Compound:st037455|FD-Score:4.61|P-value:8.81E-6 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-4.48|P-value:1.42E-5 ID:SGTC_1815|Compound:st051655|FD-Score:4.11|P-value:6.46E-5 ID:SGTC_1860|Compound:st056228|FD-Score:-3.65|P-value:3.25E-4 ID:SGTC_1968|Compound:st069590|FD-Score:-6.34|P-value:1.58E-9 ID:SGTC_2046|Compound:4110841|FD-Score:5.83|P-value:2.82E-8 ID:SGTC_2183|Compound:6420625|FD-Score:5.15|P-value:8.23E-7 ID:SGTC_2217|Compound:6934799|FD-Score:3.39|P-value:8.05E-4 ID:SGTC_2305|Compound:7443522|FD-Score:4.41|P-value:2.00E-5 ID:SGTC_2336|Compound:9001819|FD-Score:-3.70|P-value:2.68E-4 ID:SGTC_2415|Compound:st077333|FD-Score:5.14|P-value:8.58E-7 ID:SGTC_2436|Compound:5633522|FD-Score:4.08|P-value:7.38E-5 ID:SGTC_2521|Compound:angolensin|FD-Score:3.74|P-value:2.51E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:4.82|P-value:3.68E-6 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:4.58|P-value:1.01E-5 ID:SGTC_2739|Compound:tacrine|FD-Score:-3.80|P-value:1.92E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:-6.64|P-value:2.79E-10 ID:SGTC_2896|Compound:9052656|FD-Score:4.45|P-value:1.75E-5 ID:SGTC_2965|Compound:9082772|FD-Score:-3.48|P-value:5.73E-4 ID:SGTC_2968|Compound:9090663|FD-Score:5.18|P-value:7.15E-7 ID:SGTC_2969|Compound:9091408|FD-Score:4.61|P-value:8.78E-6 ID:SGTC_3027|Compound:9089541|FD-Score:4.94|P-value:2.15E-6 ID:SGTC_3050|Compound:9093513|FD-Score:3.56|P-value:4.67E-4 ID:SGTC_3081|Compound:9117243|FD-Score:5.46|P-value:1.85E-7 ID:SGTC_3355|Compound:9151058|FD-Score:4.27|P-value:3.56E-5 ID:SGTC_15|Compound:0266-0086|FD-Score:6.46|P-value:8.75E-10 ID:SGTC_117|Compound:lucigenin|FD-Score:-4.72|P-value:5.19E-6 ID:SGTC_157|Compound:1348-1695|FD-Score:5.72|P-value:5.13E-8 ID:SGTC_197|Compound:4544-0043|FD-Score:5.86|P-value:2.43E-8 ID:SGTC_205|Compound:1486-1330|FD-Score:3.59|P-value:4.21E-4 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:3.39|P-value:7.97E-4 ID:SGTC_263|Compound:alizarin|FD-Score:5.82|P-value:2.99E-8 ID:SGTC_288|Compound:1315-0019|FD-Score:4.38|P-value:2.29E-5 ID:SGTC_339|Compound:3091-4833|FD-Score:3.92|P-value:1.33E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-3.96|P-value:1.06E-4 ID:SGTC_398|Compound:bronopol|FD-Score:-5.06|P-value:1.16E-6 ID:SGTC_530|Compound:4358-1714|FD-Score:4.06|P-value:8.07E-5 ID:SGTC_539|Compound:4859-0462|FD-Score:-8.29|P-value:4.90E-15 ID:SGTC_641|Compound:4092-0595|FD-Score:3.63|P-value:3.65E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:4.09|P-value:7.22E-5 ID:SGTC_959|Compound:1222-0044|FD-Score:3.49|P-value:5.84E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:7.10|P-value:1.84E-11 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:5.52|P-value:1.36E-7 ID:SGTC_1078|Compound:idebenone|FD-Score:5.48|P-value:1.71E-7 ID:SGTC_1080|Compound:nisoldipine|FD-Score:3.46|P-value:6.36E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-3.70|P-value:2.68E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:3.91|P-value:1.40E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:3.40|P-value:7.85E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:4.62|P-value:8.59E-6 ID:SGTC_1358|Compound:1509-0022|FD-Score:4.37|P-value:2.35E-5 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.87|P-value:1.56E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:-3.32|P-value:9.46E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.48|P-value:6.03E-4 ID:SGTC_1442|Compound:4112-3290|FD-Score:3.79|P-value:2.09E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:4.01|P-value:9.72E-5 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:6.29|P-value:2.40E-9 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:3.73|P-value:2.64E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:7.72|P-value:3.17E-13 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.61|P-value:8.31E-6 ID:SGTC_1741|Compound:st038134|FD-Score:4.01|P-value:9.43E-5 ID:SGTC_1748|Compound:st037455|FD-Score:4.61|P-value:8.81E-6 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-4.48|P-value:1.42E-5 ID:SGTC_1815|Compound:st051655|FD-Score:4.11|P-value:6.46E-5 ID:SGTC_1860|Compound:st056228|FD-Score:-3.65|P-value:3.25E-4 ID:SGTC_1968|Compound:st069590|FD-Score:-6.34|P-value:1.58E-9 ID:SGTC_2046|Compound:4110841|FD-Score:5.83|P-value:2.82E-8 ID:SGTC_2183|Compound:6420625|FD-Score:5.15|P-value:8.23E-7 ID:SGTC_2217|Compound:6934799|FD-Score:3.39|P-value:8.05E-4 ID:SGTC_2305|Compound:7443522|FD-Score:4.41|P-value:2.00E-5 ID:SGTC_2336|Compound:9001819|FD-Score:-3.70|P-value:2.68E-4 ID:SGTC_2415|Compound:st077333|FD-Score:5.14|P-value:8.58E-7 ID:SGTC_2436|Compound:5633522|FD-Score:4.08|P-value:7.38E-5 ID:SGTC_2521|Compound:angolensin|FD-Score:3.74|P-value:2.51E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:4.82|P-value:3.68E-6 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:4.58|P-value:1.01E-5 ID:SGTC_2739|Compound:tacrine|FD-Score:-3.80|P-value:1.92E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:-6.64|P-value:2.79E-10 ID:SGTC_2896|Compound:9052656|FD-Score:4.45|P-value:1.75E-5 ID:SGTC_2965|Compound:9082772|FD-Score:-3.48|P-value:5.73E-4 ID:SGTC_2968|Compound:9090663|FD-Score:5.18|P-value:7.15E-7 ID:SGTC_2969|Compound:9091408|FD-Score:4.61|P-value:8.78E-6 ID:SGTC_3027|Compound:9089541|FD-Score:4.94|P-value:2.15E-6 ID:SGTC_3050|Compound:9093513|FD-Score:3.56|P-value:4.67E-4 ID:SGTC_3081|Compound:9117243|FD-Score:5.46|P-value:1.85E-7 ID:SGTC_3355|Compound:9151058|FD-Score:4.27|P-value:3.56E-5

Top fitness defect scores for YOR310C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1597 7-benzyloxygramine 7.72 47.5 µM 3.17E-13 calcium & mitochondrial duress 23 5.68E-15 0.24
2 SGTC_1074 carmofur 7.10 3.8 µM 1.84E-11 exosome 11 6.04E-13 0.69
3 SGTC_15 0266-0086 6.46 27.1 µM 8.75E-10 endomembrane recycling 5 5.08E-11 0.62
4 SGTC_1579 chlormadinone acetate 6.29 49.4 µM 2.40E-9 2 1.62E-10 1.39
5 SGTC_197 4544-0043 5.86 41.6 µM 2.43E-8 endomembrane recycling 10 2.31E-9 0.19
6 SGTC_2046 4110841 5.83 106.0 µM 2.82E-8 iron homeostasis 4 2.74E-9 0.61
7 SGTC_263 alizarin 5.82 107.9 µM 2.99E-8 iron homeostasis 2 2.93E-9 0.00
8 SGTC_157 1348-1695 5.72 65.8 µM 5.13E-8 iron homeostasis 20 5.42E-9 0.29
9 SGTC_1077 5-fluorocytosine 5.52 377.0 nM 1.36E-7 exosome 13 1.66E-8 0.53
10 SGTC_1078 idebenone 5.48 36.1 µM 1.71E-7 Golgi 2 2.16E-8 1.38
11 SGTC_3081 9117243 5.46 49.5 µM 1.85E-7 fatty acid desaturase (OLE1) 17 2.37E-8 0.32
12 SGTC_2968 9090663 5.18 33.4 µM 7.15E-7 7 1.11E-7 0.02
13 SGTC_2183 6420625 5.15 130.5 µM 8.23E-7 mitochondrial processes 9 1.31E-7 0.75
14 SGTC_2415 st077333 5.14 57.7 µM 8.58E-7 8 1.37E-7 0.47
15 SGTC_3027 9089541 4.94 49.5 µM 2.15E-6 fatty acid desaturase (OLE1) 9 3.94E-7 0.01
16 SGTC_2586 curcumin 4.82 80.0 µM 3.68E-6 iron homeostasis 4 7.29E-7 0.11
17 SGTC_1354 1498-1681 4.62 81.0 µM 8.59E-6 3 1.93E-6 0.16
18 SGTC_2969 9091408 4.61 28.7 µM 8.78E-6 2 1.97E-6 0.56
19 SGTC_1748 st037455 4.61 53.6 µM 8.81E-6 3 1.98E-6 0.14
20 SGTC_2675 theaflavin digallate 4.58 100.0 µM 1.01E-5 iron homeostasis 3 2.32E-6 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.215 2.78E-36 YJR040W GEF1 hom Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism
0.204 9.12E-33 YDR269C_d YDR269C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.164 1.25E-21 YGR195W SKI6 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4)
0.158 3.57E-20 YJL094C KHA1 hom Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies
0.156 1.23E-19 YDR270W CCC2 hom Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism
0.140 3.29E-16 YNL259C ATX1 hom Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake
0.137 1.51E-15 YOL021C DIS3 het Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3; protein abundance increases in response to DNA replication stress
0.133 1.06E-14 YDR271C_d YDR271C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W
0.130 3.82E-14 YDL111C RRP42 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp42p (EXOSC7)
0.128 1.06E-13 YLR214W FRE1 hom Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels
0.126 3.08E-13 YGR253C PUP2 het Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta
0.124 5.21E-13 YPL044C_d YPL044C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP4/YPL043W
0.122 1.27E-12 YER145C FTR1 hom High affinity iron permease; involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron; protein abundance increases in response to DNA replication stress
0.122 1.34E-12 YPR142C_d YPR142C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RRP15, which is required for ribosomal RNA processing
0.120 3.18E-12 YNL061W NOP2 het Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles