YOR316C / COT1

Vacuolar transporter that mediates zinc transport into the vacuole; overexpression confers resistance to cobalt and rhodium; protein abundance increases in response to DNA replication stress; COT1 has a paralog, ZRC1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR316C / COT1

Click on Significant Values for Screen Details ID:SGTC_95|Compound:0471-0001|FD-Score:4.33|P-value:2.02E-5 ID:SGTC_165|Compound:k038-0023|FD-Score:6.42|P-value:5.51E-10 ID:SGTC_184|Compound:1494-0393|FD-Score:4.69|P-value:4.25E-6 ID:SGTC_283|Compound:0987-0079|FD-Score:-3.59|P-value:2.99E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:4.06|P-value:5.89E-5 ID:SGTC_424|Compound:splitomicin|FD-Score:3.44|P-value:5.51E-4 ID:SGTC_554|Compound:4483-2211|FD-Score:4.55|P-value:7.96E-6 ID:SGTC_711|Compound:k292-0785|FD-Score:3.36|P-value:7.22E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:4.26|P-value:2.66E-5 ID:SGTC_934|Compound:2950-0684|FD-Score:3.86|P-value:1.26E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:-3.25|P-value:9.25E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:4.13|P-value:4.38E-5 ID:SGTC_1453|Compound:4237-0541|FD-Score:-4.07|P-value:5.06E-5 ID:SGTC_1522|Compound:st012842|FD-Score:4.08|P-value:5.50E-5 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.48|P-value:4.83E-4 ID:SGTC_1770|Compound:st043884|FD-Score:4.40|P-value:1.52E-5 ID:SGTC_1782|Compound:st039423|FD-Score:-3.55|P-value:3.49E-4 ID:SGTC_2052|Compound:5265182|FD-Score:3.63|P-value:2.85E-4 ID:SGTC_2061|Compound:5245884|FD-Score:3.36|P-value:7.13E-4 ID:SGTC_2065|Compound:5221596|FD-Score:3.40|P-value:6.26E-4 ID:SGTC_2201|Compound:6605497|FD-Score:4.30|P-value:2.26E-5 ID:SGTC_2292|Compound:7671323|FD-Score:6.78|P-value:5.78E-11 ID:SGTC_2296|Compound:7971656|FD-Score:3.33|P-value:8.02E-4 ID:SGTC_2346|Compound:9031566|FD-Score:3.77|P-value:1.74E-4 ID:SGTC_2473|Compound:5854593|FD-Score:3.97|P-value:8.23E-5 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.71|P-value:2.21E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:5.07|P-value:7.49E-7 ID:SGTC_2765|Compound:myclobutanil|FD-Score:-3.45|P-value:4.87E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:-3.25|P-value:9.42E-4 ID:SGTC_2796|Compound:7949634|FD-Score:3.74|P-value:1.94E-4 ID:SGTC_2902|Compound:5787006|FD-Score:5.93|P-value:8.70E-9 ID:SGTC_2906|Compound:7926292|FD-Score:4.47|P-value:1.10E-5 ID:SGTC_2916|Compound:7875993|FD-Score:4.51|P-value:9.40E-6 ID:SGTC_3071|Compound:9117417|FD-Score:3.82|P-value:1.45E-4 ID:SGTC_3348|Compound:9149464|FD-Score:3.47|P-value:5.01E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:4.33|P-value:2.02E-5 ID:SGTC_165|Compound:k038-0023|FD-Score:6.42|P-value:5.51E-10 ID:SGTC_184|Compound:1494-0393|FD-Score:4.69|P-value:4.25E-6 ID:SGTC_283|Compound:0987-0079|FD-Score:-3.59|P-value:2.99E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:4.06|P-value:5.89E-5 ID:SGTC_424|Compound:splitomicin|FD-Score:3.44|P-value:5.51E-4 ID:SGTC_554|Compound:4483-2211|FD-Score:4.55|P-value:7.96E-6 ID:SGTC_711|Compound:k292-0785|FD-Score:3.36|P-value:7.22E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:4.26|P-value:2.66E-5 ID:SGTC_934|Compound:2950-0684|FD-Score:3.86|P-value:1.26E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:-3.25|P-value:9.25E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:4.13|P-value:4.38E-5 ID:SGTC_1453|Compound:4237-0541|FD-Score:-4.07|P-value:5.06E-5 ID:SGTC_1522|Compound:st012842|FD-Score:4.08|P-value:5.50E-5 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.48|P-value:4.83E-4 ID:SGTC_1770|Compound:st043884|FD-Score:4.40|P-value:1.52E-5 ID:SGTC_1782|Compound:st039423|FD-Score:-3.55|P-value:3.49E-4 ID:SGTC_2052|Compound:5265182|FD-Score:3.63|P-value:2.85E-4 ID:SGTC_2061|Compound:5245884|FD-Score:3.36|P-value:7.13E-4 ID:SGTC_2065|Compound:5221596|FD-Score:3.40|P-value:6.26E-4 ID:SGTC_2201|Compound:6605497|FD-Score:4.30|P-value:2.26E-5 ID:SGTC_2292|Compound:7671323|FD-Score:6.78|P-value:5.78E-11 ID:SGTC_2296|Compound:7971656|FD-Score:3.33|P-value:8.02E-4 ID:SGTC_2346|Compound:9031566|FD-Score:3.77|P-value:1.74E-4 ID:SGTC_2473|Compound:5854593|FD-Score:3.97|P-value:8.23E-5 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.71|P-value:2.21E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:5.07|P-value:7.49E-7 ID:SGTC_2765|Compound:myclobutanil|FD-Score:-3.45|P-value:4.87E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:-3.25|P-value:9.42E-4 ID:SGTC_2796|Compound:7949634|FD-Score:3.74|P-value:1.94E-4 ID:SGTC_2902|Compound:5787006|FD-Score:5.93|P-value:8.70E-9 ID:SGTC_2906|Compound:7926292|FD-Score:4.47|P-value:1.10E-5 ID:SGTC_2916|Compound:7875993|FD-Score:4.51|P-value:9.40E-6 ID:SGTC_3071|Compound:9117417|FD-Score:3.82|P-value:1.45E-4 ID:SGTC_3348|Compound:9149464|FD-Score:3.47|P-value:5.01E-4

Top fitness defect scores for YOR316C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2292 7671323 6.78 168.1 µM 5.78E-11 RNA processing & uracil transport 4 5.84E-12
2 SGTC_165 k038-0023 6.42 64.4 µM 5.51E-10 ubiquinone biosynthesis & proteasome 20 7.03E-11
3 SGTC_2902 5787006 5.93 60.5 µM 8.70E-9 Golgi 4 1.48E-9
4 SGTC_2750 bromebric acid 5.07 70.2 µM 7.49E-7 12 2.01E-7
5 SGTC_184 1494-0393 4.69 24.7 µM 4.25E-6 41 1.36E-6
6 SGTC_554 4483-2211 4.55 187.0 µM 7.96E-6 10 2.72E-6
7 SGTC_2916 7875993 4.51 68.8 µM 9.40E-6 13 3.26E-6
8 SGTC_2906 7926292 4.47 26.4 µM 1.10E-5 16 3.89E-6
9 SGTC_1770 st043884 4.40 66.3 µM 1.52E-5 9 5.53E-6
10 SGTC_95 0471-0001 4.33 561.1 µM 2.02E-5 19 7.58E-6
11 SGTC_2201 6605497 4.30 169.9 µM 2.26E-5 ergosterol biosynthesis 5 8.58E-6
12 SGTC_816 0325-0417 4.26 81.3 µM 2.66E-5 7 1.02E-5
13 SGTC_1245 0418-0076 4.13 17.2 µM 4.38E-5 ERG2 28 1.78E-5
14 SGTC_1522 st012842 4.08 45.6 µM 5.50E-5 RNA pol III & RNase P/MRP 21 2.29E-5
15 SGTC_302 1094-0063 4.06 18.9 µM 5.89E-5 12 2.46E-5
16 SGTC_2473 5854593 3.97 8.9 µM 8.23E-5 10 3.56E-5
17 SGTC_934 2950-0684 3.86 338.0 µM 1.26E-4 24 5.67E-5
18 SGTC_3071 9117417 3.82 49.5 µM 1.45E-4 fatty acid desaturase (OLE1) 18 6.66E-5
19 SGTC_2346 9031566 3.77 143.8 µM 1.74E-4 Golgi 21 8.12E-5
20 SGTC_2796 7949634 3.74 45.5 µM 1.94E-4 20 9.17E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.119 3.99E-12 YOR023C AHC1 hom Subunit of the Ada histone acetyltransferase complex, required for structural integrity of the complex
0.115 2.66E-11 YJL027C_p YJL027C_p hom Putative protein of unknown function
0.105 1.08E-9 YJR025C BNA1 hom 3-hydroxyanthranilic acid dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p
0.096 2.39E-8 YPL038W MET31 hom Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; MET31 has a paralog, MET32, that arose from the whole genome duplication
0.089 2.22E-7 YMR187C_p YMR187C_p hom Putative protein of unknown function; YMR187C is not an essential gene
0.086 5.98E-7 YHR181W SVP26 hom Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment
0.083 1.35E-6 YOL088C MPD2 hom Member of the protein disulfide isomerase (PDI) family, exhibits chaperone activity; overexpression suppresses the lethality of a pdi1 deletion but does not complement all Pdi1p functions; undergoes oxidation by Ero1p
0.079 4.05E-6 YPL091W GLR1 hom Cytosolic and mitochondrial glutathione oxidoreductase; converts oxidized glutathione to reduced glutathione; mitochondrial but not cytosolic form has a role in resistance to hyperoxia; protein abundance increases in response to DNA replication stress
0.079 4.53E-6 YER146W LSM5 het Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
0.078 5.97E-6 YGR084C MRP13 hom Mitochondrial ribosomal protein of the small subunit
0.077 7.54E-6 YNL281W HCH1 hom Heat shock protein regulator; binds to Hsp90p and may stimulate ATPase activity; originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutation; GFP-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress
0.077 7.85E-6 YOR291W YPK9 hom Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome
0.076 1.05E-5 YNL075W IMP4 het Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs
0.074 1.98E-5 YAL025C MAK16 het Essential nuclear protein, constituent of 66S pre-ribosomal particles; required for maturation of 25S and 5.8S rRNAs; required for maintenance of M1 satellite double-stranded RNA of the L-A virus
0.074 1.99E-5 YIL132C CSM2 hom Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function; structural analysis reveals a similar DNA-binding region in both Psy3p and Csm2p and that both regions work together to form a single DNA binding site; required for accurate chromosome segregation during meiosis