YPL008W / CHL1

Probable DNA helicase; involved in sister-chromatid cohesion and genome integrity and interstrand cross-link repair; interacts with ECO1 and CTF18; mutants are defective in silencing, rDNA recombination, aging and the heat shock response; FANCJ-like helicase family member; mutations in the human homolog, DDX11/ChLR1, cause Warsaw breakage syndrome

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL008W / CHL1

Click on Significant Values for Screen Details ID:SGTC_45|Compound:0kpi-0036|FD-Score:4.11|P-value:1.95E-5 ID:SGTC_114|Compound:0364-0001|FD-Score:4.78|P-value:8.51E-7 ID:SGTC_227|Compound:fluconazole|FD-Score:-4.10|P-value:1.63E-5 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.33|P-value:4.43E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:3.24|P-value:6.04E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:5.16|P-value:1.18E-7 ID:SGTC_514|Compound:4466-0038|FD-Score:3.55|P-value:1.90E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:3.49|P-value:2.45E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:-3.34|P-value:3.48E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:-4.13|P-value:1.44E-5 ID:SGTC_558|Compound:k064-0027|FD-Score:3.16|P-value:7.93E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:3.43|P-value:3.07E-4 ID:SGTC_615|Compound:k087-0205|FD-Score:5.96|P-value:1.15E-9 ID:SGTC_620|Compound:0109-0052|FD-Score:3.22|P-value:6.39E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:3.95|P-value:3.82E-5 ID:SGTC_704|Compound:1310-0270|FD-Score:5.85|P-value:2.24E-9 ID:SGTC_754|Compound:3474-0146|FD-Score:3.57|P-value:1.79E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:4.18|P-value:1.41E-5 ID:SGTC_959|Compound:1222-0044|FD-Score:3.36|P-value:3.92E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:4.57|P-value:2.32E-6 ID:SGTC_1142|Compound:3253-1408|FD-Score:4.07|P-value:2.29E-5 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.69|P-value:1.12E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.30|P-value:4.92E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.58|P-value:1.71E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:4.84|P-value:6.21E-7 ID:SGTC_1651|Compound:st011928|FD-Score:5.37|P-value:3.62E-8 ID:SGTC_1675|Compound:st018485|FD-Score:3.74|P-value:9.32E-5 ID:SGTC_1726|Compound:st035556|FD-Score:3.69|P-value:1.13E-4 ID:SGTC_1895|Compound:st058434|FD-Score:4.04|P-value:2.67E-5 ID:SGTC_1907|Compound:st060210|FD-Score:5.64|P-value:8.05E-9 ID:SGTC_1934|Compound:st074720|FD-Score:-3.10|P-value:8.13E-4 ID:SGTC_2082|Compound:5219693|FD-Score:3.63|P-value:1.41E-4 ID:SGTC_2173|Compound:5763948|FD-Score:3.30|P-value:4.93E-4 ID:SGTC_2277|Compound:7947813|FD-Score:5.19|P-value:9.86E-8 ID:SGTC_2526|Compound:patulin|FD-Score:3.22|P-value:6.40E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:4.30|P-value:8.51E-6 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:4.92|P-value:4.15E-7 ID:SGTC_2695|Compound:st077686|FD-Score:-4.77|P-value:6.90E-7 ID:SGTC_2842|Compound:9000675|FD-Score:4.96|P-value:3.38E-7 ID:SGTC_2869|Compound:9037858|FD-Score:3.40|P-value:3.34E-4 ID:SGTC_2931|Compound:9014674|FD-Score:3.14|P-value:8.57E-4 ID:SGTC_3067|Compound:9117431|FD-Score:3.84|P-value:6.25E-5 ID:SGTC_3311|Compound:9131146|FD-Score:4.00|P-value:3.16E-5 ID:SGTC_3321|Compound:9137793|FD-Score:4.74|P-value:1.01E-6 ID:SGTC_3322|Compound:9139058|FD-Score:5.46|P-value:2.26E-8 ID:SGTC_45|Compound:0kpi-0036|FD-Score:4.11|P-value:1.95E-5 ID:SGTC_114|Compound:0364-0001|FD-Score:4.78|P-value:8.51E-7 ID:SGTC_227|Compound:fluconazole|FD-Score:-4.10|P-value:1.63E-5 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.33|P-value:4.43E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:3.24|P-value:6.04E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:5.16|P-value:1.18E-7 ID:SGTC_514|Compound:4466-0038|FD-Score:3.55|P-value:1.90E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:3.49|P-value:2.45E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:-3.34|P-value:3.48E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:-4.13|P-value:1.44E-5 ID:SGTC_558|Compound:k064-0027|FD-Score:3.16|P-value:7.93E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:3.43|P-value:3.07E-4 ID:SGTC_615|Compound:k087-0205|FD-Score:5.96|P-value:1.15E-9 ID:SGTC_620|Compound:0109-0052|FD-Score:3.22|P-value:6.39E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:3.95|P-value:3.82E-5 ID:SGTC_704|Compound:1310-0270|FD-Score:5.85|P-value:2.24E-9 ID:SGTC_754|Compound:3474-0146|FD-Score:3.57|P-value:1.79E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:4.18|P-value:1.41E-5 ID:SGTC_959|Compound:1222-0044|FD-Score:3.36|P-value:3.92E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:4.57|P-value:2.32E-6 ID:SGTC_1142|Compound:3253-1408|FD-Score:4.07|P-value:2.29E-5 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.69|P-value:1.12E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.30|P-value:4.92E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.58|P-value:1.71E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:4.84|P-value:6.21E-7 ID:SGTC_1651|Compound:st011928|FD-Score:5.37|P-value:3.62E-8 ID:SGTC_1675|Compound:st018485|FD-Score:3.74|P-value:9.32E-5 ID:SGTC_1726|Compound:st035556|FD-Score:3.69|P-value:1.13E-4 ID:SGTC_1895|Compound:st058434|FD-Score:4.04|P-value:2.67E-5 ID:SGTC_1907|Compound:st060210|FD-Score:5.64|P-value:8.05E-9 ID:SGTC_1934|Compound:st074720|FD-Score:-3.10|P-value:8.13E-4 ID:SGTC_2082|Compound:5219693|FD-Score:3.63|P-value:1.41E-4 ID:SGTC_2173|Compound:5763948|FD-Score:3.30|P-value:4.93E-4 ID:SGTC_2277|Compound:7947813|FD-Score:5.19|P-value:9.86E-8 ID:SGTC_2526|Compound:patulin|FD-Score:3.22|P-value:6.40E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:4.30|P-value:8.51E-6 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:4.92|P-value:4.15E-7 ID:SGTC_2695|Compound:st077686|FD-Score:-4.77|P-value:6.90E-7 ID:SGTC_2842|Compound:9000675|FD-Score:4.96|P-value:3.38E-7 ID:SGTC_2869|Compound:9037858|FD-Score:3.40|P-value:3.34E-4 ID:SGTC_2931|Compound:9014674|FD-Score:3.14|P-value:8.57E-4 ID:SGTC_3067|Compound:9117431|FD-Score:3.84|P-value:6.25E-5 ID:SGTC_3311|Compound:9131146|FD-Score:4.00|P-value:3.16E-5 ID:SGTC_3321|Compound:9137793|FD-Score:4.74|P-value:1.01E-6 ID:SGTC_3322|Compound:9139058|FD-Score:5.46|P-value:2.26E-8

Top fitness defect scores for YPL008W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_615 k087-0205 5.96 167.0 µM 1.15E-9 3 1.26E-9
2 SGTC_704 1310-0270 5.85 142.0 µM 2.24E-9 8 2.44E-9
3 SGTC_1907 st060210 5.64 83.7 µM 8.05E-9 5 8.69E-9
4 SGTC_3322 9139058 5.46 2.1 µM 2.26E-8 cell wall 8 2.42E-8
5 SGTC_1651 st011928 5.37 86.1 µM 3.62E-8 RSC complex & mRNA processing 6 3.86E-8
6 SGTC_2277 7947813 5.19 106.9 µM 9.86E-8 RSC complex & mRNA processing 12 1.04E-7
7 SGTC_354 2783-3500 5.16 4.9 µM 1.18E-7 cell wall 27 1.24E-7
8 SGTC_2842 9000675 4.96 19.5 µM 3.38E-7 7 3.54E-7
9 SGTC_2636 apigenin dimethyl ether 4.92 100.0 µM 4.15E-7 18 4.33E-7
10 SGTC_1583 clindamycin 4.84 39.6 µM 6.21E-7 mitochondrial processes 5 6.46E-7
11 SGTC_114 0364-0001 4.78 490.3 µM 8.51E-7 21 8.82E-7
12 SGTC_3321 9137793 4.74 26.8 µM 1.01E-6 cell wall 50 1.05E-6
13 SGTC_993 3909-8757 4.57 62.7 µM 2.32E-6 14 2.38E-6
14 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 4.30 15.3 µM 8.51E-6 25 8.66E-6
15 SGTC_851 0394-0702 4.18 453.0 µM 1.41E-5 mitochondrial processes 8 1.43E-5
16 SGTC_45 0kpi-0036 4.11 14.9 µM 1.95E-5 excess fatty acid 18 1.97E-5
17 SGTC_1142 3253-1408 4.07 9.8 µM 2.29E-5 10 2.31E-5
18 SGTC_1895 st058434 4.04 18.3 µM 2.67E-5 15 2.69E-5
19 SGTC_3311 9131146 4.00 2.9 µM 3.16E-5 cell wall 119 3.18E-5
20 SGTC_648 0375-0473 3.95 33.3 µM 3.82E-5 16 3.85E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.165 7.02E-22 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.160 1.01E-20 YMR036C MIH1 hom Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25
0.151 1.37E-18 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.138 8.69E-16 YDR483W KRE2 hom Alpha1,2-mannosyltransferase of the Golgi; involved in protein mannosylation; KRE2 has a paralog, KTR6, that arose from the whole genome duplication
0.133 8.68E-15 YDL066W IDP1 hom Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
0.127 1.36E-13 YGR056W RSC1 hom Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook
0.120 2.58E-12 YEL061C CIN8 hom Kinesin motor protein involved in mitotic spindle assembly and chromosome segregation
0.119 4.06E-12 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.113 5.80E-11 YBL061C SKT5 hom Activator of Chs3p (chitin synthase III) during vegetative growth; recruits Chs3p to the bud neck via interaction with Bni4p; SKT5 has a paralog, SHC1, that arose from the whole genome duplication
0.111 9.60E-11 YBL062W_d YBL062W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.111 1.00E-10 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.110 1.44E-10 YNR040W_p YNR040W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.107 5.75E-10 YNL022C_p YNL022C_p hom Putative cytosine 5-methyltransferase, contains seven beta-strand methyltransferase motif similar to NOP2/YNL061W; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; predicted to be involved in ribosome biogenesis
0.106 8.00E-10 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
0.105 9.72E-10 YBL006C LDB7 hom Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions