HIPHOP chemogenomics database

YPL031C / PHO85

Cyclin-dependent kinase, with ten cyclin partners; involved in regulating the cellular response to nutrient levels and environmental conditions and progression through the cell cycle

Zygosity: Homozygous strain

fixedexpanded
Profile for YPL031C / PHO85

Click on Significant Values for Screen Details

Top fitness defect scores for YPL031C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2988	9073640	5.27	71.4 µM	6.37E-7		10	6.65E-8
2	SGTC_1047	2043-3044	5.27	82.0 µM	6.47E-7		12	6.76E-8
3	SGTC_1484	3473-2379	4.86	286.0 µM	4.19E-6		5	5.93E-7
4	SGTC_1386	3228-0095	4.77	33.8 µM	6.00E-6		8	8.99E-7
5	SGTC_1455	4262-0120	4.40	131.0 µM	2.87E-5	plasma membrane duress	20	5.52E-6
6	SGTC_1665	st014639	4.35	11.4 µM	3.39E-5	NEO1	16	6.70E-6
7	SGTC_2767	sibutramine	4.32	71.5 µM	3.92E-5		15	7.94E-6
8	SGTC_86	0417-1630	4.31	471.9 µM	4.09E-5	ubiquinone biosynthesis & proteasome	132	8.34E-6
9	SGTC_1253	0550-0034	4.22	176.0 µM	5.59E-5		16	1.20E-5
10	SGTC_2146	5545642	4.18	200.0 µM	6.57E-5		11	1.45E-5
11	SGTC_1382	3002-2117	4.06	298.0 µM	1.04E-4		10	2.48E-5
12	SGTC_134	0269-0018	4.01	6.9 µM	1.23E-4		130	2.99E-5
13	SGTC_1660	st012960	3.89	28.1 µM	1.88E-4	iron homeostasis	38	4.93E-5
14	SGTC_165	k038-0023	3.85	64.4 µM	2.17E-4	ubiquinone biosynthesis & proteasome	83	5.79E-5
15	SGTC_1025	k007-0731	3.85	70.0 µM	2.18E-4		15	5.82E-5
16	SGTC_1755	st041960	3.84	45.2 µM	2.28E-4		29	6.15E-5
17	SGTC_2409	alverine citrate	3.78	64.0 µM	2.79E-4		57	7.78E-5
18	SGTC_3013	9080133	3.70	71.4 µM	3.68E-4		26	1.07E-4
19	SGTC_200	k038-0079	3.68	37.5 µM	3.95E-4	ubiquinone biosynthesis & proteasome	61	1.17E-4
20	SGTC_1668	st014914	3.67	51.6 µM	4.07E-4	RPP1 & pyrimidine depletion	4	1.21E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.139	5.45E-16	YML034C-A_d	YML034C-A_d	hom	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.127	1.82E-13	YOR254C	SEC63	het	Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.124	5.78E-13	YGL119W	COQ8	hom	Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.117	9.28E-12	YML034W	SRC1	hom	Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance
0.117	1.03E-11	YNL111C	CYB5	hom	Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation
0.113	4.76E-11	YBR003W	COQ1	hom	Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.113	4.86E-11	YCL034W	LSB5	hom	Protein of unknown function; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; may mediate disassembly of the Pan1 complex from the endocytic coat
0.113	5.94E-11	YNR041C	COQ2	hom	Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.099	9.87E-9	YGR159C	NSR1	hom	Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis
0.098	1.08E-8	YDL074C	BRE1	hom	E3 ubiquitin ligase, forms heterodimer with Rad6p to monoubiquinate histone H2B-K123, which is required for the subsequent methylation of histone H3-K4 and H3-K79; required for DSBR, transcription, silencing, and checkpoint control
0.096	2.78E-8	YJL168C	SET2	hom	Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
0.095	3.11E-8	YDR363W-A	SEM1	hom	Component of lid subcomplex of the 26S proteasome regulatory subunit; involved in mRNA export mediated by the TREX-2 complex (Sac3p-Thp1p); ortholog of human DSS1; protein abundance increases in response to DNA replication stress
0.093	6.69E-8	YGR255C	COQ6	hom	Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)
0.092	9.56E-8	YLR021W	IRC25	hom	Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions
0.091	1.28E-7	YFL001W	DEG1	hom	tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm; non-essential for viability