YPL031C / PHO85

Cyclin-dependent kinase, with ten cyclin partners; involved in regulating the cellular response to nutrient levels and environmental conditions and progression through the cell cycle

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL031C / PHO85

Click on Significant Values for Screen Details ID:SGTC_86|Compound:0417-1630|FD-Score:4.31|P-value:4.09E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:4.01|P-value:1.23E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:3.43|P-value:8.98E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:-4.14|P-value:4.13E-5 ID:SGTC_165|Compound:k038-0023|FD-Score:3.85|P-value:2.17E-4 ID:SGTC_200|Compound:k038-0079|FD-Score:3.68|P-value:3.95E-4 ID:SGTC_211|Compound:3455-0679|FD-Score:-3.38|P-value:6.23E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.82|P-value:2.36E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.23|P-value:2.84E-5 ID:SGTC_626|Compound:0214-0009|FD-Score:-3.66|P-value:2.38E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:-3.39|P-value:5.93E-4 ID:SGTC_984|Compound:1492-0255|FD-Score:3.57|P-value:5.66E-4 ID:SGTC_1025|Compound:k007-0731|FD-Score:3.85|P-value:2.18E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:5.27|P-value:6.47E-7 ID:SGTC_1052|Compound:3253-3998|FD-Score:-5.80|P-value:2.06E-8 ID:SGTC_1246|Compound:0422-0085|FD-Score:-11.30|P-value:1.66E-26 ID:SGTC_1252|Compound:0493-0875|FD-Score:-6.62|P-value:2.06E-10 ID:SGTC_1253|Compound:0550-0034|FD-Score:4.22|P-value:5.59E-5 ID:SGTC_1382|Compound:3002-2117|FD-Score:4.06|P-value:1.04E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:4.77|P-value:6.00E-6 ID:SGTC_1455|Compound:4262-0120|FD-Score:4.40|P-value:2.87E-5 ID:SGTC_1484|Compound:3473-2379|FD-Score:4.86|P-value:4.19E-6 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:-3.55|P-value:3.49E-4 ID:SGTC_1652|Compound:st011932|FD-Score:-3.77|P-value:1.62E-4 ID:SGTC_1660|Compound:st012960|FD-Score:3.89|P-value:1.88E-4 ID:SGTC_1665|Compound:st014639|FD-Score:4.35|P-value:3.39E-5 ID:SGTC_1668|Compound:st014914|FD-Score:3.67|P-value:4.07E-4 ID:SGTC_1755|Compound:st041960|FD-Score:3.84|P-value:2.28E-4 ID:SGTC_1779|Compound:st039427|FD-Score:-3.88|P-value:1.08E-4 ID:SGTC_2146|Compound:5545642|FD-Score:4.18|P-value:6.57E-5 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.78|P-value:2.79E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:-4.04|P-value:5.90E-5 ID:SGTC_2738|Compound:aclarubicin|FD-Score:-3.27|P-value:8.83E-4 ID:SGTC_2746|Compound:daunorubicin|FD-Score:-3.35|P-value:6.91E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:4.32|P-value:3.92E-5 ID:SGTC_2919|Compound:7978188|FD-Score:-4.80|P-value:2.66E-6 ID:SGTC_2926|Compound:9010726|FD-Score:-3.49|P-value:4.34E-4 ID:SGTC_2988|Compound:9073640|FD-Score:5.27|P-value:6.37E-7 ID:SGTC_3013|Compound:9080133|FD-Score:3.70|P-value:3.68E-4 ID:SGTC_3199|Compound:9111318|FD-Score:-3.66|P-value:2.44E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:4.31|P-value:4.09E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:4.01|P-value:1.23E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:3.43|P-value:8.98E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:-4.14|P-value:4.13E-5 ID:SGTC_165|Compound:k038-0023|FD-Score:3.85|P-value:2.17E-4 ID:SGTC_200|Compound:k038-0079|FD-Score:3.68|P-value:3.95E-4 ID:SGTC_211|Compound:3455-0679|FD-Score:-3.38|P-value:6.23E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.82|P-value:2.36E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.23|P-value:2.84E-5 ID:SGTC_626|Compound:0214-0009|FD-Score:-3.66|P-value:2.38E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:-3.39|P-value:5.93E-4 ID:SGTC_984|Compound:1492-0255|FD-Score:3.57|P-value:5.66E-4 ID:SGTC_1025|Compound:k007-0731|FD-Score:3.85|P-value:2.18E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:5.27|P-value:6.47E-7 ID:SGTC_1052|Compound:3253-3998|FD-Score:-5.80|P-value:2.06E-8 ID:SGTC_1246|Compound:0422-0085|FD-Score:-11.30|P-value:1.66E-26 ID:SGTC_1252|Compound:0493-0875|FD-Score:-6.62|P-value:2.06E-10 ID:SGTC_1253|Compound:0550-0034|FD-Score:4.22|P-value:5.59E-5 ID:SGTC_1382|Compound:3002-2117|FD-Score:4.06|P-value:1.04E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:4.77|P-value:6.00E-6 ID:SGTC_1455|Compound:4262-0120|FD-Score:4.40|P-value:2.87E-5 ID:SGTC_1484|Compound:3473-2379|FD-Score:4.86|P-value:4.19E-6 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:-3.55|P-value:3.49E-4 ID:SGTC_1652|Compound:st011932|FD-Score:-3.77|P-value:1.62E-4 ID:SGTC_1660|Compound:st012960|FD-Score:3.89|P-value:1.88E-4 ID:SGTC_1665|Compound:st014639|FD-Score:4.35|P-value:3.39E-5 ID:SGTC_1668|Compound:st014914|FD-Score:3.67|P-value:4.07E-4 ID:SGTC_1755|Compound:st041960|FD-Score:3.84|P-value:2.28E-4 ID:SGTC_1779|Compound:st039427|FD-Score:-3.88|P-value:1.08E-4 ID:SGTC_2146|Compound:5545642|FD-Score:4.18|P-value:6.57E-5 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.78|P-value:2.79E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:-4.04|P-value:5.90E-5 ID:SGTC_2738|Compound:aclarubicin|FD-Score:-3.27|P-value:8.83E-4 ID:SGTC_2746|Compound:daunorubicin|FD-Score:-3.35|P-value:6.91E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:4.32|P-value:3.92E-5 ID:SGTC_2919|Compound:7978188|FD-Score:-4.80|P-value:2.66E-6 ID:SGTC_2926|Compound:9010726|FD-Score:-3.49|P-value:4.34E-4 ID:SGTC_2988|Compound:9073640|FD-Score:5.27|P-value:6.37E-7 ID:SGTC_3013|Compound:9080133|FD-Score:3.70|P-value:3.68E-4 ID:SGTC_3199|Compound:9111318|FD-Score:-3.66|P-value:2.44E-4

Top fitness defect scores for YPL031C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2988 9073640 5.27 71.4 µM 6.37E-7 10 6.65E-8
2 SGTC_1047 2043-3044 5.27 82.0 µM 6.47E-7 12 6.76E-8
3 SGTC_1484 3473-2379 4.86 286.0 µM 4.19E-6 5 5.93E-7
4 SGTC_1386 3228-0095 4.77 33.8 µM 6.00E-6 8 8.99E-7
5 SGTC_1455 4262-0120 4.40 131.0 µM 2.87E-5 plasma membrane duress 20 5.52E-6
6 SGTC_1665 st014639 4.35 11.4 µM 3.39E-5 NEO1 16 6.70E-6
7 SGTC_2767 sibutramine 4.32 71.5 µM 3.92E-5 15 7.94E-6
8 SGTC_86 0417-1630 4.31 471.9 µM 4.09E-5 ubiquinone biosynthesis & proteasome 132 8.34E-6
9 SGTC_1253 0550-0034 4.22 176.0 µM 5.59E-5 16 1.20E-5
10 SGTC_2146 5545642 4.18 200.0 µM 6.57E-5 11 1.45E-5
11 SGTC_1382 3002-2117 4.06 298.0 µM 1.04E-4 10 2.48E-5
12 SGTC_134 0269-0018 4.01 6.9 µM 1.23E-4 130 2.99E-5
13 SGTC_1660 st012960 3.89 28.1 µM 1.88E-4 iron homeostasis 38 4.93E-5
14 SGTC_165 k038-0023 3.85 64.4 µM 2.17E-4 ubiquinone biosynthesis & proteasome 83 5.79E-5
15 SGTC_1025 k007-0731 3.85 70.0 µM 2.18E-4 15 5.82E-5
16 SGTC_1755 st041960 3.84 45.2 µM 2.28E-4 29 6.15E-5
17 SGTC_2409 alverine citrate 3.78 64.0 µM 2.79E-4 57 7.78E-5
18 SGTC_3013 9080133 3.70 71.4 µM 3.68E-4 26 1.07E-4
19 SGTC_200 k038-0079 3.68 37.5 µM 3.95E-4 ubiquinone biosynthesis & proteasome 61 1.17E-4
20 SGTC_1668 st014914 3.67 51.6 µM 4.07E-4 RPP1 & pyrimidine depletion 4 1.21E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.139 5.45E-16 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.127 1.82E-13 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.124 5.78E-13 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.117 9.28E-12 YML034W SRC1 hom Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance
0.117 1.03E-11 YNL111C CYB5 hom Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation
0.113 4.76E-11 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.113 4.86E-11 YCL034W LSB5 hom Protein of unknown function; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; may mediate disassembly of the Pan1 complex from the endocytic coat
0.113 5.94E-11 YNR041C COQ2 hom Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.099 9.87E-9 YGR159C NSR1 hom Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis
0.098 1.08E-8 YDL074C BRE1 hom E3 ubiquitin ligase, forms heterodimer with Rad6p to monoubiquinate histone H2B-K123, which is required for the subsequent methylation of histone H3-K4 and H3-K79; required for DSBR, transcription, silencing, and checkpoint control
0.096 2.78E-8 YJL168C SET2 hom Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
0.095 3.11E-8 YDR363W-A SEM1 hom Component of lid subcomplex of the 26S proteasome regulatory subunit; involved in mRNA export mediated by the TREX-2 complex (Sac3p-Thp1p); ortholog of human DSS1; protein abundance increases in response to DNA replication stress
0.093 6.69E-8 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)
0.092 9.56E-8 YLR021W IRC25 hom Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions
0.091 1.28E-7 YFL001W DEG1 hom tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm; non-essential for viability