YPL046C / ELC1

Elongin C, conserved among eukaryotes; forms a complex with Cul3p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; plays a role in global genomic repair

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL046C / ELC1

Click on Significant Values for Screen Details ID:SGTC_88|Compound:0180-0332|FD-Score:-3.56|P-value:7.84E-5 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.62|P-value:4.23E-5 ID:SGTC_448|Compound:monastrol|FD-Score:3.04|P-value:4.68E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-3.00|P-value:7.31E-4 ID:SGTC_526|Compound:4469-0568|FD-Score:-3.03|P-value:6.67E-4 ID:SGTC_619|Compound:1652-1634|FD-Score:3.26|P-value:2.00E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:2.87|P-value:9.09E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:3.47|P-value:8.06E-5 ID:SGTC_725|Compound:1497-0963|FD-Score:3.34|P-value:1.44E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:3.95|P-value:8.99E-6 ID:SGTC_810|Compound:3825-7150|FD-Score:3.06|P-value:4.37E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:2.84|P-value:9.84E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:-2.93|P-value:9.33E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:-4.91|P-value:8.44E-8 ID:SGTC_1045|Compound:1348-1485|FD-Score:-4.84|P-value:1.22E-7 ID:SGTC_1052|Compound:3253-3998|FD-Score:-2.94|P-value:9.20E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:2.85|P-value:9.63E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.83|P-value:1.60E-5 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.00|P-value:5.55E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:-3.06|P-value:5.96E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:4.09|P-value:4.68E-6 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.93|P-value:1.48E-5 ID:SGTC_1650|Compound:st011916|FD-Score:3.35|P-value:1.38E-4 ID:SGTC_1729|Compound:st035615|FD-Score:-4.92|P-value:7.73E-8 ID:SGTC_1871|Compound:st057448|FD-Score:3.42|P-value:1.01E-4 ID:SGTC_2022|Compound:5136654|FD-Score:2.92|P-value:7.46E-4 ID:SGTC_2029|Compound:5175081|FD-Score:3.36|P-value:1.33E-4 ID:SGTC_2045|Compound:5106652|FD-Score:3.36|P-value:1.33E-4 ID:SGTC_2177|Compound:5811945|FD-Score:4.08|P-value:4.76E-6 ID:SGTC_2178|Compound:5812956|FD-Score:4.73|P-value:1.51E-7 ID:SGTC_2254|Compound:7938975|FD-Score:4.43|P-value:7.81E-7 ID:SGTC_2303|Compound:7774051|FD-Score:2.91|P-value:7.76E-4 ID:SGTC_2312|Compound:7706453|FD-Score:3.49|P-value:7.71E-5 ID:SGTC_2355|Compound:9061122|FD-Score:3.54|P-value:6.20E-5 ID:SGTC_2456|Compound:5770359|FD-Score:3.94|P-value:9.61E-6 ID:SGTC_2462|Compound:5162487|FD-Score:3.05|P-value:4.60E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:3.31|P-value:1.59E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:-2.98|P-value:7.86E-4 ID:SGTC_2820|Compound:7989630|FD-Score:4.56|P-value:3.86E-7 ID:SGTC_2821|Compound:7996764|FD-Score:-3.65|P-value:5.31E-5 ID:SGTC_2926|Compound:9010726|FD-Score:3.30|P-value:1.66E-4 ID:SGTC_3000|Compound:9075062|FD-Score:-4.36|P-value:1.71E-6 ID:SGTC_3004|Compound:9076122|FD-Score:3.71|P-value:2.87E-5 ID:SGTC_3009|Compound:9080819|FD-Score:4.09|P-value:4.70E-6 ID:SGTC_3014|Compound:9081533|FD-Score:-4.10|P-value:6.41E-6 ID:SGTC_3016|Compound:9080866|FD-Score:3.89|P-value:1.24E-5 ID:SGTC_3141|Compound:9094609|FD-Score:3.67|P-value:3.47E-5 ID:SGTC_3152|Compound:9099253|FD-Score:2.99|P-value:5.75E-4 ID:SGTC_3216|Compound:9129716|FD-Score:4.10|P-value:4.36E-6 ID:SGTC_3222|Compound:9128301|FD-Score:3.22|P-value:2.35E-4 ID:SGTC_3268|Compound:9137683|FD-Score:-3.45|P-value:1.23E-4 ID:SGTC_3274|Compound:9138298|FD-Score:-3.25|P-value:2.82E-4 ID:SGTC_3326|Compound:9140064|FD-Score:-2.97|P-value:8.26E-4 ID:SGTC_88|Compound:0180-0332|FD-Score:-3.56|P-value:7.84E-5 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.62|P-value:4.23E-5 ID:SGTC_448|Compound:monastrol|FD-Score:3.04|P-value:4.68E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-3.00|P-value:7.31E-4 ID:SGTC_526|Compound:4469-0568|FD-Score:-3.03|P-value:6.67E-4 ID:SGTC_619|Compound:1652-1634|FD-Score:3.26|P-value:2.00E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:2.87|P-value:9.09E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:3.47|P-value:8.06E-5 ID:SGTC_725|Compound:1497-0963|FD-Score:3.34|P-value:1.44E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:3.95|P-value:8.99E-6 ID:SGTC_810|Compound:3825-7150|FD-Score:3.06|P-value:4.37E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:2.84|P-value:9.84E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:-2.93|P-value:9.33E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:-4.91|P-value:8.44E-8 ID:SGTC_1045|Compound:1348-1485|FD-Score:-4.84|P-value:1.22E-7 ID:SGTC_1052|Compound:3253-3998|FD-Score:-2.94|P-value:9.20E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:2.85|P-value:9.63E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.83|P-value:1.60E-5 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.00|P-value:5.55E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:-3.06|P-value:5.96E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:4.09|P-value:4.68E-6 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.93|P-value:1.48E-5 ID:SGTC_1650|Compound:st011916|FD-Score:3.35|P-value:1.38E-4 ID:SGTC_1729|Compound:st035615|FD-Score:-4.92|P-value:7.73E-8 ID:SGTC_1871|Compound:st057448|FD-Score:3.42|P-value:1.01E-4 ID:SGTC_2022|Compound:5136654|FD-Score:2.92|P-value:7.46E-4 ID:SGTC_2029|Compound:5175081|FD-Score:3.36|P-value:1.33E-4 ID:SGTC_2045|Compound:5106652|FD-Score:3.36|P-value:1.33E-4 ID:SGTC_2177|Compound:5811945|FD-Score:4.08|P-value:4.76E-6 ID:SGTC_2178|Compound:5812956|FD-Score:4.73|P-value:1.51E-7 ID:SGTC_2254|Compound:7938975|FD-Score:4.43|P-value:7.81E-7 ID:SGTC_2303|Compound:7774051|FD-Score:2.91|P-value:7.76E-4 ID:SGTC_2312|Compound:7706453|FD-Score:3.49|P-value:7.71E-5 ID:SGTC_2355|Compound:9061122|FD-Score:3.54|P-value:6.20E-5 ID:SGTC_2456|Compound:5770359|FD-Score:3.94|P-value:9.61E-6 ID:SGTC_2462|Compound:5162487|FD-Score:3.05|P-value:4.60E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:3.31|P-value:1.59E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:-2.98|P-value:7.86E-4 ID:SGTC_2820|Compound:7989630|FD-Score:4.56|P-value:3.86E-7 ID:SGTC_2821|Compound:7996764|FD-Score:-3.65|P-value:5.31E-5 ID:SGTC_2926|Compound:9010726|FD-Score:3.30|P-value:1.66E-4 ID:SGTC_3000|Compound:9075062|FD-Score:-4.36|P-value:1.71E-6 ID:SGTC_3004|Compound:9076122|FD-Score:3.71|P-value:2.87E-5 ID:SGTC_3009|Compound:9080819|FD-Score:4.09|P-value:4.70E-6 ID:SGTC_3014|Compound:9081533|FD-Score:-4.10|P-value:6.41E-6 ID:SGTC_3016|Compound:9080866|FD-Score:3.89|P-value:1.24E-5 ID:SGTC_3141|Compound:9094609|FD-Score:3.67|P-value:3.47E-5 ID:SGTC_3152|Compound:9099253|FD-Score:2.99|P-value:5.75E-4 ID:SGTC_3216|Compound:9129716|FD-Score:4.10|P-value:4.36E-6 ID:SGTC_3222|Compound:9128301|FD-Score:3.22|P-value:2.35E-4 ID:SGTC_3268|Compound:9137683|FD-Score:-3.45|P-value:1.23E-4 ID:SGTC_3274|Compound:9138298|FD-Score:-3.25|P-value:2.82E-4 ID:SGTC_3326|Compound:9140064|FD-Score:-2.97|P-value:8.26E-4

Top fitness defect scores for YPL046C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2178 5812956 4.73 200.0 µM 1.51E-7 6 1.12E-6
2 SGTC_2820 7989630 4.56 71.4 µM 3.86E-7 ERG2 10 2.52E-6
3 SGTC_2254 7938975 4.43 95.2 µM 7.81E-7 41 4.63E-6
4 SGTC_3216 9129716 4.10 49.5 µM 4.36E-6 RPP1 & pyrimidine depletion 21 2.05E-5
5 SGTC_1454 4239-0054 4.09 42.6 µM 4.68E-6 30 2.18E-5
6 SGTC_3009 9080819 4.09 71.4 µM 4.70E-6 15 2.19E-5
7 SGTC_2177 5811945 4.08 192.0 µM 4.76E-6 25 2.21E-5
8 SGTC_788 1182-0090 3.95 188.0 µM 8.99E-6 endomembrane recycling 77 3.83E-5
9 SGTC_2456 5770359 3.94 74.5 µM 9.61E-6 16 4.06E-5
10 SGTC_3016 9080866 3.89 49.5 µM 1.24E-5 27 5.06E-5
11 SGTC_1133 3473-0247 3.83 50.0 µM 1.60E-5 RSC complex & mRNA processing 56 6.31E-5
12 SGTC_3004 9076122 3.71 71.4 µM 2.87E-5 18 1.04E-4
13 SGTC_3141 9094609 3.67 49.5 µM 3.47E-5 iron homeostasis 43 1.23E-4
14 SGTC_421 streptovitacin 3.62 30.0 mM 4.23E-5 31 1.46E-4
15 SGTC_2355 9061122 3.54 103.1 µM 6.20E-5 19 2.04E-4
16 SGTC_2312 7706453 3.49 155.7 µM 7.71E-5 42 2.46E-4
17 SGTC_663 1486-0733 3.47 13.9 µM 8.06E-5 cell wall signaling 77 2.56E-4
18 SGTC_1871 st057448 3.42 67.3 µM 1.01E-4 43 3.11E-4
19 SGTC_2045 5106652 3.36 78.0 µM 1.33E-4 34 3.95E-4
20 SGTC_2029 5175081 3.36 200.0 µM 1.33E-4 41 3.95E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.097 1.88E-8 YOR301W RAX1 hom Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily
0.091 1.16E-7 YLR429W CRN1 hom Coronin, cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity; plays a role in regulation of actin patch assembly
0.087 5.18E-7 YNL335W_p DDI3_p hom Protein of unknown function; expression is induced over 100-fold by DNA damage; induction decreased in rad6 and rad18 mutants
0.084 9.82E-7 YBL047C EDE1 hom Endocytic protein; involved in a network of interactions with other endocytic proteins, binds membranes in a ubiquitin-dependent manner, may also bind ubiquitinated membrane-associated proteins; interacts with Cmk2 and functions upstream of CMK2 in regulating non-apoptotic cell death
0.080 3.80E-6 YBL008W-A_p YBL008W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.080 3.84E-6 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.078 6.29E-6 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.077 8.30E-6 YIR013C GAT4 hom Protein containing GATA family zinc finger motifs
0.077 9.02E-6 YCR073W-A SOL2 hom Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL2 has a paralog, SOL1, that arose from the whole genome duplication
0.075 1.33E-5 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.075 1.36E-5 YBL094C_d YBL094C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YBL095W
0.074 1.81E-5 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.074 1.86E-5 YFR034C PHO4 hom Basic helix-loop-helix (bHLH) transcription factor of the myc-family; activates transcription cooperatively with Pho2p in response to phosphate limitation; binding to 'CACGTG' motif is regulated by chromatin restriction, competitive binding of Cbf1p to the same DNA binding motif and cooperation with Pho2p,; function is regulated by phosphorylation at multiple sites and by phosphate availability
0.074 1.91E-5 YFL048C EMP47 hom Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport
0.074 2.00E-5 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol