YPL054W / LEE1

Zinc-finger protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL054W / LEE1

Click on Significant Values for Screen Details ID:SGTC_149|Compound:3970-0822|FD-Score:-3.17|P-value:4.85E-4 ID:SGTC_191|Compound:3914-0123|FD-Score:-3.05|P-value:7.81E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:2.96|P-value:7.18E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:-3.11|P-value:6.12E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:-3.35|P-value:2.49E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-3.03|P-value:8.33E-4 ID:SGTC_561|Compound:1550-0330|FD-Score:3.53|P-value:7.44E-5 ID:SGTC_777|Compound:1315-0167|FD-Score:3.38|P-value:1.40E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:3.08|P-value:4.57E-4 ID:SGTC_847|Compound:0342-0274|FD-Score:3.57|P-value:6.25E-5 ID:SGTC_855|Compound:0428-0020|FD-Score:3.31|P-value:1.84E-4 ID:SGTC_861|Compound:0443-0273|FD-Score:3.44|P-value:1.08E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:3.42|P-value:1.18E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:-3.27|P-value:3.40E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.26|P-value:2.32E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:3.40|P-value:1.32E-4 ID:SGTC_1291|Compound:0993-0025|FD-Score:3.16|P-value:3.40E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:4.00|P-value:8.87E-6 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.12|P-value:3.89E-4 ID:SGTC_1406|Compound:3909-7906|FD-Score:3.09|P-value:4.41E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:-3.65|P-value:7.29E-5 ID:SGTC_1567|Compound:st069303|FD-Score:4.37|P-value:1.45E-6 ID:SGTC_1945|Compound:st075991|FD-Score:3.45|P-value:1.06E-4 ID:SGTC_1956|Compound:st077085|FD-Score:3.50|P-value:8.37E-5 ID:SGTC_2012|Compound:4023501|FD-Score:-3.04|P-value:7.98E-4 ID:SGTC_2013|Compound:4024628|FD-Score:-3.17|P-value:5.02E-4 ID:SGTC_2186|Compound:6124449|FD-Score:4.79|P-value:1.53E-7 ID:SGTC_2306|Compound:7482397|FD-Score:3.63|P-value:4.85E-5 ID:SGTC_2375|Compound:9072683|FD-Score:4.42|P-value:1.09E-6 ID:SGTC_2411|Compound:st077133|FD-Score:4.45|P-value:9.55E-7 ID:SGTC_2428|Compound:5615643|FD-Score:4.07|P-value:6.52E-6 ID:SGTC_2610|Compound:ononetin|FD-Score:3.78|P-value:2.45E-5 ID:SGTC_2611|Compound:pyromycin|FD-Score:-3.37|P-value:2.32E-4 ID:SGTC_2646|Compound:retinol|FD-Score:-3.36|P-value:2.36E-4 ID:SGTC_2649|Compound:anisomycin|FD-Score:4.43|P-value:1.05E-6 ID:SGTC_2819|Compound:7996655|FD-Score:-3.16|P-value:5.14E-4 ID:SGTC_3055|Compound:9094636|FD-Score:-3.19|P-value:4.57E-4 ID:SGTC_3185|Compound:9108267|FD-Score:3.20|P-value:2.91E-4 ID:SGTC_3308|Compound:9128332|FD-Score:-3.47|P-value:1.50E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:-3.17|P-value:4.85E-4 ID:SGTC_191|Compound:3914-0123|FD-Score:-3.05|P-value:7.81E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:2.96|P-value:7.18E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:-3.11|P-value:6.12E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:-3.35|P-value:2.49E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-3.03|P-value:8.33E-4 ID:SGTC_561|Compound:1550-0330|FD-Score:3.53|P-value:7.44E-5 ID:SGTC_777|Compound:1315-0167|FD-Score:3.38|P-value:1.40E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:3.08|P-value:4.57E-4 ID:SGTC_847|Compound:0342-0274|FD-Score:3.57|P-value:6.25E-5 ID:SGTC_855|Compound:0428-0020|FD-Score:3.31|P-value:1.84E-4 ID:SGTC_861|Compound:0443-0273|FD-Score:3.44|P-value:1.08E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:3.42|P-value:1.18E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:-3.27|P-value:3.40E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.26|P-value:2.32E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:3.40|P-value:1.32E-4 ID:SGTC_1291|Compound:0993-0025|FD-Score:3.16|P-value:3.40E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:4.00|P-value:8.87E-6 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.12|P-value:3.89E-4 ID:SGTC_1406|Compound:3909-7906|FD-Score:3.09|P-value:4.41E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:-3.65|P-value:7.29E-5 ID:SGTC_1567|Compound:st069303|FD-Score:4.37|P-value:1.45E-6 ID:SGTC_1945|Compound:st075991|FD-Score:3.45|P-value:1.06E-4 ID:SGTC_1956|Compound:st077085|FD-Score:3.50|P-value:8.37E-5 ID:SGTC_2012|Compound:4023501|FD-Score:-3.04|P-value:7.98E-4 ID:SGTC_2013|Compound:4024628|FD-Score:-3.17|P-value:5.02E-4 ID:SGTC_2186|Compound:6124449|FD-Score:4.79|P-value:1.53E-7 ID:SGTC_2306|Compound:7482397|FD-Score:3.63|P-value:4.85E-5 ID:SGTC_2375|Compound:9072683|FD-Score:4.42|P-value:1.09E-6 ID:SGTC_2411|Compound:st077133|FD-Score:4.45|P-value:9.55E-7 ID:SGTC_2428|Compound:5615643|FD-Score:4.07|P-value:6.52E-6 ID:SGTC_2610|Compound:ononetin|FD-Score:3.78|P-value:2.45E-5 ID:SGTC_2611|Compound:pyromycin|FD-Score:-3.37|P-value:2.32E-4 ID:SGTC_2646|Compound:retinol|FD-Score:-3.36|P-value:2.36E-4 ID:SGTC_2649|Compound:anisomycin|FD-Score:4.43|P-value:1.05E-6 ID:SGTC_2819|Compound:7996655|FD-Score:-3.16|P-value:5.14E-4 ID:SGTC_3055|Compound:9094636|FD-Score:-3.19|P-value:4.57E-4 ID:SGTC_3185|Compound:9108267|FD-Score:3.20|P-value:2.91E-4 ID:SGTC_3308|Compound:9128332|FD-Score:-3.47|P-value:1.50E-4

Top fitness defect scores for YPL054W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2186 6124449 4.79 200.0 µM 1.53E-7 RSC complex & mRNA processing 11 8.47E-7
2 SGTC_2411 st077133 4.45 39.9 µM 9.55E-7 RNA pol III & RNase P/MRP 19 4.32E-6
3 SGTC_2649 anisomycin 4.43 9.6 µM 1.05E-6 5 4.69E-6
4 SGTC_2375 9072683 4.42 200.0 µM 1.09E-6 mitochondrial processes 11 4.87E-6
5 SGTC_1567 st069303 4.37 68.4 µM 1.45E-6 mitochondrial processes 10 6.25E-6
6 SGTC_2428 5615643 4.07 7.8 µM 6.52E-6 31 2.37E-5
7 SGTC_1350 1495-0454 4.00 146.0 µM 8.87E-6 25 3.12E-5
8 SGTC_2610 ononetin 3.78 44.2 µM 2.45E-5 49 7.70E-5
9 SGTC_2306 7482397 3.63 179.5 µM 4.85E-5 RPP1 & pyrimidine depletion 31 1.41E-4
10 SGTC_847 0342-0274 3.57 5.5 µM 6.25E-5 28 1.77E-4
11 SGTC_561 1550-0330 3.53 72.9 µM 7.44E-5 21 2.06E-4
12 SGTC_1956 st077085 3.50 54.0 µM 8.37E-5 29 2.29E-4
13 SGTC_1945 st075991 3.45 56.6 µM 1.06E-4 60S ribosome export 35 2.82E-4
14 SGTC_861 0443-0273 3.44 110.0 µM 1.08E-4 23 2.86E-4
15 SGTC_937 3122-0005 3.42 46.7 µM 1.18E-4 42 3.10E-4
16 SGTC_1277 0873-0036 3.40 22.0 µM 1.32E-4 PDR1 43 3.42E-4
17 SGTC_777 1315-0167 3.38 517.0 µM 1.40E-4 Golgi 45 3.62E-4
18 SGTC_855 0428-0020 3.31 25.0 µM 1.84E-4 Golgi 40 4.60E-4
19 SGTC_1179 1021-1431 3.26 9.3 µM 2.32E-4 77 5.66E-4
20 SGTC_3185 9108267 3.20 49.5 µM 2.91E-4 60S ribosome export 49 6.92E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.118 6.75E-12 YNL221C POP1 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P
0.114 3.57E-11 YPL011C TAF3 het TFIID subunit (47 kDa), involved in promoter binding and RNA polymerase II transcription initiation
0.112 9.45E-11 YOR260W GCD1 het Gamma subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
0.098 1.52E-8 YCR048W ARE1 hom Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the absence of oxygen; ARE1 has a paralog, ARE2, that arose from the whole genome duplication
0.094 5.19E-8 YMR272W-B_p YMR272W-B_p hom Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.084 1.11E-6 YLR291C GCD7 het Beta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
0.083 1.28E-6 YCL038C ATG22 hom Vacuolar integral membrane protein required for efflux of amino acids during autophagic body breakdown in the vacuole; null mutation causes a gradual loss of viability during starvation
0.078 6.44E-6 YPL137C GIP3 hom Cytoplasmic protein that regulates protein phosphatase 1 Glc7p; overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; may interact with ribosomes, based on co-purification experiments; GIP3 has a paralog, HER1, that arose from the whole genome duplication
0.075 1.25E-5 YGR083C GCD2 het Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
0.075 1.34E-5 YNL281W HCH1 hom Heat shock protein regulator; binds to Hsp90p and may stimulate ATPase activity; originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutation; GFP-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress
0.075 1.51E-5 YDR195W REF2 hom RNA-binding protein involved in the cleavage step of mRNA 3'-end formation prior to polyadenylation, and in snoRNA maturation; part of holo-CPF subcomplex APT, which associates with 3'-ends of snoRNA- and mRNA-encoding genes
0.074 1.71E-5 YMR147W_p YMR147W_p hom Putative protein of unknown function
0.071 4.32E-5 YDR055W PST1 hom Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1
0.070 4.48E-5 YJL064W_d YJL064W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL065C/DLS1
0.068 9.07E-5 YDL152W_d YDL152W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SAS10/YDL153C, a component of the small ribosomal subunit processosome