YPL104W / MSD1

Mitochondrial aspartyl-tRNA synthetase, required for acylation of aspartyl-tRNA; yeast and bacterial aspartyl-, asparaginyl-, and lysyl-tRNA synthetases contain regions with high sequence similarity, suggesting a common ancestral gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL104W / MSD1

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:3.85|P-value:3.00E-4 ID:SGTC_11|Compound:0438-0307|FD-Score:3.77|P-value:3.78E-4 ID:SGTC_19|Compound:0279-0214|FD-Score:5.23|P-value:1.47E-6 ID:SGTC_21|Compound:0849-0113|FD-Score:4.58|P-value:2.14E-5 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:5.53|P-value:3.96E-7 ID:SGTC_147|Compound:4466-0538|FD-Score:4.78|P-value:9.67E-6 ID:SGTC_168|Compound:3970-0862|FD-Score:3.90|P-value:2.52E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:5.11|P-value:2.48E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:5.10|P-value:2.58E-6 ID:SGTC_248|Compound:streptozotocin|FD-Score:4.19|P-value:9.17E-5 ID:SGTC_251|Compound:melphalan|FD-Score:3.56|P-value:7.58E-4 ID:SGTC_373|Compound:0844-0104|FD-Score:4.20|P-value:8.87E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-4.22|P-value:7.57E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.80|P-value:3.21E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:3.71|P-value:4.68E-4 ID:SGTC_858|Compound:0438-0351|FD-Score:4.74|P-value:1.17E-5 ID:SGTC_1023|Compound:4482-3888|FD-Score:3.66|P-value:5.44E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:4.03|P-value:1.59E-4 ID:SGTC_1066|Compound:ketoconazole|FD-Score:-3.46|P-value:9.54E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:4.28|P-value:6.63E-5 ID:SGTC_1172|Compound:0370-0043|FD-Score:4.38|P-value:4.68E-5 ID:SGTC_1383|Compound:3049-0032|FD-Score:5.61|P-value:2.75E-7 ID:SGTC_1388|Compound:3346-4487|FD-Score:4.32|P-value:5.67E-5 ID:SGTC_1564|Compound:D-Arginine|FD-Score:4.46|P-value:3.42E-5 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:6.24|P-value:1.22E-8 ID:SGTC_1602|Compound:st001878|FD-Score:-4.24|P-value:6.94E-5 ID:SGTC_1610|Compound:st001799|FD-Score:3.50|P-value:8.84E-4 ID:SGTC_1616|Compound:st002734|FD-Score:-3.92|P-value:2.18E-4 ID:SGTC_1881|Compound:5652484|FD-Score:3.71|P-value:4.70E-4 ID:SGTC_1921|Compound:5740136|FD-Score:3.91|P-value:2.42E-4 ID:SGTC_1942|Compound:st076330|FD-Score:4.17|P-value:9.71E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.91|P-value:2.45E-4 ID:SGTC_2381|Compound:9035592|FD-Score:6.52|P-value:2.80E-9 ID:SGTC_2719|Compound:novobiocin|FD-Score:3.51|P-value:8.67E-4 ID:SGTC_2720|Compound:fluspirilene|FD-Score:4.18|P-value:9.38E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:5.13|P-value:2.28E-6 ID:SGTC_2771|Compound:fluoxetine|FD-Score:3.51|P-value:8.58E-4 ID:SGTC_2801|Compound:7907800|FD-Score:3.86|P-value:2.83E-4 ID:SGTC_2813|Compound:7971799|FD-Score:4.35|P-value:5.09E-5 ID:SGTC_2908|Compound:7930301|FD-Score:5.28|P-value:1.21E-6 ID:SGTC_2968|Compound:9090663|FD-Score:-7.23|P-value:4.42E-11 ID:SGTC_2986|Compound:9022445|FD-Score:-4.27|P-value:6.26E-5 ID:SGTC_3094|Compound:9117742|FD-Score:3.89|P-value:2.58E-4 ID:SGTC_3142|Compound:9086498|FD-Score:-4.54|P-value:2.27E-5 ID:SGTC_3211|Compound:9128781|FD-Score:3.70|P-value:4.80E-4 ID:SGTC_3333|Compound:9141820|FD-Score:-3.47|P-value:9.23E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:3.85|P-value:3.00E-4 ID:SGTC_11|Compound:0438-0307|FD-Score:3.77|P-value:3.78E-4 ID:SGTC_19|Compound:0279-0214|FD-Score:5.23|P-value:1.47E-6 ID:SGTC_21|Compound:0849-0113|FD-Score:4.58|P-value:2.14E-5 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:5.53|P-value:3.96E-7 ID:SGTC_147|Compound:4466-0538|FD-Score:4.78|P-value:9.67E-6 ID:SGTC_168|Compound:3970-0862|FD-Score:3.90|P-value:2.52E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:5.11|P-value:2.48E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:5.10|P-value:2.58E-6 ID:SGTC_248|Compound:streptozotocin|FD-Score:4.19|P-value:9.17E-5 ID:SGTC_251|Compound:melphalan|FD-Score:3.56|P-value:7.58E-4 ID:SGTC_373|Compound:0844-0104|FD-Score:4.20|P-value:8.87E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-4.22|P-value:7.57E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.80|P-value:3.21E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:3.71|P-value:4.68E-4 ID:SGTC_858|Compound:0438-0351|FD-Score:4.74|P-value:1.17E-5 ID:SGTC_1023|Compound:4482-3888|FD-Score:3.66|P-value:5.44E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:4.03|P-value:1.59E-4 ID:SGTC_1066|Compound:ketoconazole|FD-Score:-3.46|P-value:9.54E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:4.28|P-value:6.63E-5 ID:SGTC_1172|Compound:0370-0043|FD-Score:4.38|P-value:4.68E-5 ID:SGTC_1383|Compound:3049-0032|FD-Score:5.61|P-value:2.75E-7 ID:SGTC_1388|Compound:3346-4487|FD-Score:4.32|P-value:5.67E-5 ID:SGTC_1564|Compound:D-Arginine|FD-Score:4.46|P-value:3.42E-5 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:6.24|P-value:1.22E-8 ID:SGTC_1602|Compound:st001878|FD-Score:-4.24|P-value:6.94E-5 ID:SGTC_1610|Compound:st001799|FD-Score:3.50|P-value:8.84E-4 ID:SGTC_1616|Compound:st002734|FD-Score:-3.92|P-value:2.18E-4 ID:SGTC_1881|Compound:5652484|FD-Score:3.71|P-value:4.70E-4 ID:SGTC_1921|Compound:5740136|FD-Score:3.91|P-value:2.42E-4 ID:SGTC_1942|Compound:st076330|FD-Score:4.17|P-value:9.71E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.91|P-value:2.45E-4 ID:SGTC_2381|Compound:9035592|FD-Score:6.52|P-value:2.80E-9 ID:SGTC_2719|Compound:novobiocin|FD-Score:3.51|P-value:8.67E-4 ID:SGTC_2720|Compound:fluspirilene|FD-Score:4.18|P-value:9.38E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:5.13|P-value:2.28E-6 ID:SGTC_2771|Compound:fluoxetine|FD-Score:3.51|P-value:8.58E-4 ID:SGTC_2801|Compound:7907800|FD-Score:3.86|P-value:2.83E-4 ID:SGTC_2813|Compound:7971799|FD-Score:4.35|P-value:5.09E-5 ID:SGTC_2908|Compound:7930301|FD-Score:5.28|P-value:1.21E-6 ID:SGTC_2968|Compound:9090663|FD-Score:-7.23|P-value:4.42E-11 ID:SGTC_2986|Compound:9022445|FD-Score:-4.27|P-value:6.26E-5 ID:SGTC_3094|Compound:9117742|FD-Score:3.89|P-value:2.58E-4 ID:SGTC_3142|Compound:9086498|FD-Score:-4.54|P-value:2.27E-5 ID:SGTC_3211|Compound:9128781|FD-Score:3.70|P-value:4.80E-4 ID:SGTC_3333|Compound:9141820|FD-Score:-3.47|P-value:9.23E-4

Top fitness defect scores for YPL104W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2381 9035592 6.52 200.0 µM 2.80E-9 1 3.45E-11
2 SGTC_1576 erythromycin ethylsuccinate 6.24 23.2 µM 1.22E-8 3 2.15E-10
3 SGTC_1383 3049-0032 5.61 20.7 µM 2.75E-7 60S ribosome export 1 1.03E-8
4 SGTC_28 pentachloropyridine N-oxide 5.53 1.6 µM 3.96E-7 TSC3-RPN4 22 1.62E-8
5 SGTC_2908 7930301 5.28 100.0 µM 1.21E-6 6 6.47E-8
6 SGTC_19 0279-0214 5.23 38.4 µM 1.47E-6 TRP & mitochondrial translation 18 8.30E-8
7 SGTC_2756 carbadox 5.13 75.1 µM 2.28E-6 31 1.43E-7
8 SGTC_173 1273-0061 5.11 2.7 µM 2.48E-6 mitochondrial stress 141 1.58E-7
9 SGTC_236 1509-0011 5.10 5.3 µM 2.58E-6 323 1.66E-7
10 SGTC_147 4466-0538 4.78 29.2 µM 9.67E-6 ergosterol biosynthesis 7 8.56E-7
11 SGTC_858 0438-0351 4.74 2.8 µM 1.17E-5 copper-dependent oxidative stress 8 1.09E-6
12 SGTC_21 0849-0113 4.58 23.0 µM 2.14E-5 19 2.29E-6
13 SGTC_1564 D-Arginine 4.46 115.0 µM 3.42E-5 17 4.10E-6
14 SGTC_1172 0370-0043 4.38 85.0 µM 4.68E-5 13 6.04E-6
15 SGTC_2813 7971799 4.35 71.4 µM 5.09E-5 14 6.70E-6
16 SGTC_1388 3346-4487 4.32 254.0 µM 5.67E-5 15 7.67E-6
17 SGTC_1154 4088-0362 4.28 150.0 µM 6.63E-5 15 9.29E-6
18 SGTC_373 0844-0104 4.20 25.9 µM 8.87E-5 ERAD & cell cycle 39 1.33E-5
19 SGTC_248 streptozotocin 4.19 5.2 mM 9.17E-5 DNA damage response 21 1.39E-5
20 SGTC_2720 fluspirilene 4.18 36.9 µM 9.38E-5 ERG2 10 1.43E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.194 1.39E-29 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.178 1.97E-25 YKL170W MRPL38 hom Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress
0.175 1.57E-24 YGR102C GTF1 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.166 3.87E-22 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.164 1.02E-21 YDR194C MSS116 hom DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
0.164 1.16E-21 YPL118W MRP51 hom Mitochondrial ribosomal protein of the small subunit; MRP51 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences
0.162 4.35E-21 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.160 1.12E-20 YER087W AIM10 hom Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss
0.159 2.44E-20 YPR166C MRP2 hom Mitochondrial ribosomal protein of the small subunit
0.159 2.57E-20 YOR158W PET123 hom Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator
0.152 6.45E-19 YOL095C HMI1 hom Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD
0.152 8.46E-19 YMR072W ABF2 hom Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation
0.148 7.41E-18 YBR002C RER2 het Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting
0.147 1.23E-17 YDR079W PET100 hom Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
0.146 1.70E-17 YKL138C MRPL31 hom Mitochondrial ribosomal protein of the large subunit