YPL154C / PEP4

Vacuolar aspartyl protease (proteinase A), required for the posttranslational precursor maturation of vacuolar proteinases; important for protein turnover after oxidative damage; synthesized as a zymogen, self-activates

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL154C / PEP4

Click on Significant Values for Screen Details ID:SGTC_21|Compound:0849-0113|FD-Score:3.30|P-value:8.88E-4 ID:SGTC_24|Compound:0417-1663|FD-Score:3.90|P-value:1.10E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:4.93|P-value:1.52E-6 ID:SGTC_52|Compound:0329-0193|FD-Score:3.56|P-value:3.73E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:4.13|P-value:4.65E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:3.72|P-value:2.16E-4 ID:SGTC_185|Compound:k048-0037|FD-Score:3.37|P-value:7.13E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:5.04|P-value:9.09E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.43|P-value:6.02E-4 ID:SGTC_338|Compound:4055-0136|FD-Score:3.59|P-value:3.42E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:3.56|P-value:3.74E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:-3.32|P-value:8.46E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:4.49|P-value:1.08E-5 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:4.32|P-value:2.14E-5 ID:SGTC_605|Compound:1315-0399|FD-Score:3.32|P-value:8.34E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:4.83|P-value:2.40E-6 ID:SGTC_767|Compound:0929-0023|FD-Score:3.34|P-value:7.91E-4 ID:SGTC_775|Compound:4577-0580|FD-Score:3.58|P-value:3.51E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:3.83|P-value:1.46E-4 ID:SGTC_983|Compound:1491-0821|FD-Score:-3.37|P-value:7.29E-4 ID:SGTC_1062|Compound:mesoridazine|FD-Score:4.46|P-value:1.23E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.70|P-value:2.31E-4 ID:SGTC_1169|Compound:aniline yellow|FD-Score:3.73|P-value:2.07E-4 ID:SGTC_1218|Compound:1348-1416|FD-Score:3.57|P-value:3.65E-4 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:3.52|P-value:4.22E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:3.55|P-value:3.80E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.49|P-value:4.71E-4 ID:SGTC_1619|Compound:st003326|FD-Score:4.61|P-value:6.25E-6 ID:SGTC_1720|Compound:st037298|FD-Score:-3.33|P-value:8.31E-4 ID:SGTC_1721|Compound:st082152|FD-Score:3.81|P-value:1.53E-4 ID:SGTC_1839|Compound:st053978|FD-Score:3.36|P-value:7.41E-4 ID:SGTC_1948|Compound:st076329|FD-Score:4.42|P-value:1.43E-5 ID:SGTC_1962|Compound:st076595|FD-Score:4.53|P-value:8.83E-6 ID:SGTC_2162|Compound:5663267|FD-Score:3.49|P-value:4.69E-4 ID:SGTC_2295|Compound:7971645|FD-Score:3.59|P-value:3.42E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-4.29|P-value:2.54E-5 ID:SGTC_2314|Compound:7727897|FD-Score:-3.93|P-value:1.02E-4 ID:SGTC_2340|Compound:7987427|FD-Score:5.76|P-value:2.52E-8 ID:SGTC_2341|Compound:7987486|FD-Score:4.33|P-value:2.10E-5 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:3.54|P-value:3.99E-4 ID:SGTC_2570|Compound:licareol|FD-Score:3.59|P-value:3.31E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:3.32|P-value:8.24E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:-4.04|P-value:6.72E-5 ID:SGTC_2750|Compound:bromebric acid|FD-Score:-3.64|P-value:2.86E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:3.55|P-value:3.88E-4 ID:SGTC_2913|Compound:7966556|FD-Score:3.47|P-value:5.04E-4 ID:SGTC_2920|Compound:7982904|FD-Score:4.56|P-value:7.97E-6 ID:SGTC_2928|Compound:9011484|FD-Score:4.75|P-value:3.37E-6 ID:SGTC_2948|Compound:9070189|FD-Score:3.37|P-value:7.11E-4 ID:SGTC_2973|Compound:9094665|FD-Score:4.95|P-value:1.36E-6 ID:SGTC_2974|Compound:9094440|FD-Score:-4.15|P-value:4.32E-5 ID:SGTC_2975|Compound:9084847|FD-Score:4.31|P-value:2.27E-5 ID:SGTC_3059|Compound:1327-0034|FD-Score:4.06|P-value:6.06E-5 ID:SGTC_3285|Compound:9112818|FD-Score:-5.26|P-value:3.24E-7 ID:SGTC_3288|Compound:9119690|FD-Score:5.86|P-value:1.42E-8 ID:SGTC_21|Compound:0849-0113|FD-Score:3.30|P-value:8.88E-4 ID:SGTC_24|Compound:0417-1663|FD-Score:3.90|P-value:1.10E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:4.93|P-value:1.52E-6 ID:SGTC_52|Compound:0329-0193|FD-Score:3.56|P-value:3.73E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:4.13|P-value:4.65E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:3.72|P-value:2.16E-4 ID:SGTC_185|Compound:k048-0037|FD-Score:3.37|P-value:7.13E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:5.04|P-value:9.09E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.43|P-value:6.02E-4 ID:SGTC_338|Compound:4055-0136|FD-Score:3.59|P-value:3.42E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:3.56|P-value:3.74E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:-3.32|P-value:8.46E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:4.49|P-value:1.08E-5 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:4.32|P-value:2.14E-5 ID:SGTC_605|Compound:1315-0399|FD-Score:3.32|P-value:8.34E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:4.83|P-value:2.40E-6 ID:SGTC_767|Compound:0929-0023|FD-Score:3.34|P-value:7.91E-4 ID:SGTC_775|Compound:4577-0580|FD-Score:3.58|P-value:3.51E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:3.83|P-value:1.46E-4 ID:SGTC_983|Compound:1491-0821|FD-Score:-3.37|P-value:7.29E-4 ID:SGTC_1062|Compound:mesoridazine|FD-Score:4.46|P-value:1.23E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.70|P-value:2.31E-4 ID:SGTC_1169|Compound:aniline yellow|FD-Score:3.73|P-value:2.07E-4 ID:SGTC_1218|Compound:1348-1416|FD-Score:3.57|P-value:3.65E-4 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:3.52|P-value:4.22E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:3.55|P-value:3.80E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.49|P-value:4.71E-4 ID:SGTC_1619|Compound:st003326|FD-Score:4.61|P-value:6.25E-6 ID:SGTC_1720|Compound:st037298|FD-Score:-3.33|P-value:8.31E-4 ID:SGTC_1721|Compound:st082152|FD-Score:3.81|P-value:1.53E-4 ID:SGTC_1839|Compound:st053978|FD-Score:3.36|P-value:7.41E-4 ID:SGTC_1948|Compound:st076329|FD-Score:4.42|P-value:1.43E-5 ID:SGTC_1962|Compound:st076595|FD-Score:4.53|P-value:8.83E-6 ID:SGTC_2162|Compound:5663267|FD-Score:3.49|P-value:4.69E-4 ID:SGTC_2295|Compound:7971645|FD-Score:3.59|P-value:3.42E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-4.29|P-value:2.54E-5 ID:SGTC_2314|Compound:7727897|FD-Score:-3.93|P-value:1.02E-4 ID:SGTC_2340|Compound:7987427|FD-Score:5.76|P-value:2.52E-8 ID:SGTC_2341|Compound:7987486|FD-Score:4.33|P-value:2.10E-5 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:3.54|P-value:3.99E-4 ID:SGTC_2570|Compound:licareol|FD-Score:3.59|P-value:3.31E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:3.32|P-value:8.24E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:-4.04|P-value:6.72E-5 ID:SGTC_2750|Compound:bromebric acid|FD-Score:-3.64|P-value:2.86E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:3.55|P-value:3.88E-4 ID:SGTC_2913|Compound:7966556|FD-Score:3.47|P-value:5.04E-4 ID:SGTC_2920|Compound:7982904|FD-Score:4.56|P-value:7.97E-6 ID:SGTC_2928|Compound:9011484|FD-Score:4.75|P-value:3.37E-6 ID:SGTC_2948|Compound:9070189|FD-Score:3.37|P-value:7.11E-4 ID:SGTC_2973|Compound:9094665|FD-Score:4.95|P-value:1.36E-6 ID:SGTC_2974|Compound:9094440|FD-Score:-4.15|P-value:4.32E-5 ID:SGTC_2975|Compound:9084847|FD-Score:4.31|P-value:2.27E-5 ID:SGTC_3059|Compound:1327-0034|FD-Score:4.06|P-value:6.06E-5 ID:SGTC_3285|Compound:9112818|FD-Score:-5.26|P-value:3.24E-7 ID:SGTC_3288|Compound:9119690|FD-Score:5.86|P-value:1.42E-8

Top fitness defect scores for YPL154C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3288 9119690 5.86 36.2 µM 1.42E-8 9 2.27E-9
2 SGTC_2340 7987427 5.76 183.4 µM 2.52E-8 9 4.31E-9
3 SGTC_294 k038-0071 5.04 157.0 µM 9.09E-7 ubiquinone biosynthesis & proteasome 33 2.32E-7
4 SGTC_2973 9094665 4.95 18.0 µM 1.36E-6 NEO1 13 3.63E-7
5 SGTC_50 0929-0078 4.93 56.4 µM 1.52E-6 31 4.12E-7
6 SGTC_747 3448-8087 4.83 38.7 µM 2.40E-6 10 6.84E-7
7 SGTC_2928 9011484 4.75 9.8 µM 3.37E-6 heme biosynthesis & mitochondrial translocase 22 9.97E-7
8 SGTC_1619 st003326 4.61 88.7 µM 6.25E-6 60S ribosome export 9 1.98E-6
9 SGTC_2920 7982904 4.56 15.8 µM 7.97E-6 9 2.59E-6
10 SGTC_1962 st076595 4.53 64.5 µM 8.83E-6 redox potentiating 16 2.90E-6
11 SGTC_540 1187-0821 4.49 17.3 µM 1.08E-5 8 3.65E-6
12 SGTC_1062 mesoridazine 4.46 14.2 µM 1.23E-5 12 4.19E-6
13 SGTC_1948 st076329 4.42 66.6 µM 1.43E-5 16 4.97E-6
14 SGTC_2341 7987486 4.33 176.7 µM 2.10E-5 13 7.61E-6
15 SGTC_563 tetrahydrosecaminediol 4.32 614.0 µM 2.14E-5 amide catabolism 13 7.77E-6
16 SGTC_2975 9084847 4.31 53.7 µM 2.27E-5 17 8.27E-6
17 SGTC_137 0438-0332 4.13 85.4 µM 4.65E-5 ubiquinone biosynthesis & proteasome 116 1.84E-5
18 SGTC_3059 1327-0034 4.06 3.0 µM 6.06E-5 50 2.47E-5
19 SGTC_24 0417-1663 3.90 219.0 µM 1.10E-4 18 4.80E-5
20 SGTC_958 1222-0007 3.83 33.0 µM 1.46E-4 30 6.54E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.119 3.96E-12 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.109 2.41E-10 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.099 7.66E-9 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.096 2.22E-8 YOL079W_d YOL079W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.096 2.31E-8 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.094 4.69E-8 YER012W PRE1 het Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle
0.093 7.15E-8 YFR007W YFH7 hom Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases
0.092 8.89E-8 YOR343C_d YOR343C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.092 1.09E-7 YJL155C FBP26 hom Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.090 1.69E-7 YER087C-A_d YER087C-A_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; overlaps the uncharacterized gene YER087W, a putative tRNA synthetase
0.089 2.11E-7 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.088 3.36E-7 YPR065W ROX1 hom Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance
0.084 1.00E-6 YKL077W_p YKL077W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
0.083 1.33E-6 YPR107C YTH1 het Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation
0.082 2.11E-6 YML034W SRC1 hom Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance