YPL205C_d

Hypothetical protein; deletion of locus affects telomere length

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL205C / YPL205C

Click on Significant Values for Screen Details ID:SGTC_38|Compound:0929-0051|FD-Score:3.12|P-value:9.49E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:10.80|P-value:4.26E-26 ID:SGTC_343|Compound:4130-2827|FD-Score:3.62|P-value:1.64E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.51|P-value:2.45E-4 ID:SGTC_462|Compound:ag-879|FD-Score:3.57|P-value:1.94E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:3.46|P-value:2.98E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:4.74|P-value:1.47E-6 ID:SGTC_722|Compound:3534-0461|FD-Score:4.79|P-value:1.14E-6 ID:SGTC_724|Compound:3910-0327|FD-Score:3.89|P-value:5.94E-5 ID:SGTC_740|Compound:k014-0057|FD-Score:3.91|P-value:5.41E-5 ID:SGTC_930|Compound:2810-3379|FD-Score:-3.91|P-value:1.13E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:-3.36|P-value:8.19E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.21|P-value:7.01E-4 ID:SGTC_1062|Compound:mesoridazine|FD-Score:4.90|P-value:6.88E-7 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-3.63|P-value:3.24E-4 ID:SGTC_1103|Compound:duloxetine|FD-Score:3.67|P-value:1.35E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:3.65|P-value:1.48E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.87|P-value:6.20E-5 ID:SGTC_1336|Compound:1486-0901|FD-Score:3.16|P-value:8.12E-4 ID:SGTC_1614|Compound:st002383|FD-Score:3.12|P-value:9.42E-4 ID:SGTC_1754|Compound:st042065|FD-Score:5.33|P-value:7.75E-8 ID:SGTC_1803|Compound:st050068|FD-Score:4.25|P-value:1.33E-5 ID:SGTC_1818|Compound:st052136|FD-Score:3.55|P-value:2.15E-4 ID:SGTC_1845|Compound:st056753|FD-Score:3.61|P-value:1.70E-4 ID:SGTC_1908|Compound:st060353|FD-Score:-4.85|P-value:2.21E-6 ID:SGTC_1913|Compound:st060213|FD-Score:3.31|P-value:4.94E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.19|P-value:7.43E-4 ID:SGTC_2296|Compound:7971656|FD-Score:5.25|P-value:1.19E-7 ID:SGTC_2302|Compound:7771753|FD-Score:3.74|P-value:1.03E-4 ID:SGTC_2328|Compound:6201408|FD-Score:-4.17|P-value:4.10E-5 ID:SGTC_2378|Compound:9074213|FD-Score:3.23|P-value:6.52E-4 ID:SGTC_2404|Compound:5161160|FD-Score:-3.81|P-value:1.67E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:3.19|P-value:7.56E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-3.63|P-value:3.25E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.55|P-value:2.11E-4 ID:SGTC_2601|Compound:securinine|FD-Score:4.38|P-value:7.55E-6 ID:SGTC_2608|Compound:thymoquinone|FD-Score:8.16|P-value:7.19E-16 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.27|P-value:1.23E-5 ID:SGTC_2789|Compound:5281112|FD-Score:3.58|P-value:1.89E-4 ID:SGTC_2812|Compound:7970281|FD-Score:4.12|P-value:2.26E-5 ID:SGTC_2817|Compound:7995342|FD-Score:3.90|P-value:5.50E-5 ID:SGTC_2818|Compound:7996756|FD-Score:3.63|P-value:1.60E-4 ID:SGTC_2823|Compound:7987624|FD-Score:-5.84|P-value:1.43E-8 ID:SGTC_2967|Compound:9089538|FD-Score:3.72|P-value:1.14E-4 ID:SGTC_3045|Compound:9092950|FD-Score:-3.66|P-value:2.90E-4 ID:SGTC_3056|Compound:9094900|FD-Score:4.42|P-value:6.23E-6 ID:SGTC_3137|Compound:9097352|FD-Score:5.77|P-value:7.06E-9 ID:SGTC_3181|Compound:9108277|FD-Score:3.33|P-value:4.56E-4 ID:SGTC_3186|Compound:9110464|FD-Score:-3.32|P-value:9.17E-4 ID:SGTC_3207|Compound:9114163|FD-Score:3.22|P-value:6.80E-4 ID:SGTC_3208|Compound:9114115|FD-Score:3.62|P-value:1.66E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:3.12|P-value:9.49E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:10.80|P-value:4.26E-26 ID:SGTC_343|Compound:4130-2827|FD-Score:3.62|P-value:1.64E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.51|P-value:2.45E-4 ID:SGTC_462|Compound:ag-879|FD-Score:3.57|P-value:1.94E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:3.46|P-value:2.98E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:4.74|P-value:1.47E-6 ID:SGTC_722|Compound:3534-0461|FD-Score:4.79|P-value:1.14E-6 ID:SGTC_724|Compound:3910-0327|FD-Score:3.89|P-value:5.94E-5 ID:SGTC_740|Compound:k014-0057|FD-Score:3.91|P-value:5.41E-5 ID:SGTC_930|Compound:2810-3379|FD-Score:-3.91|P-value:1.13E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:-3.36|P-value:8.19E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.21|P-value:7.01E-4 ID:SGTC_1062|Compound:mesoridazine|FD-Score:4.90|P-value:6.88E-7 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-3.63|P-value:3.24E-4 ID:SGTC_1103|Compound:duloxetine|FD-Score:3.67|P-value:1.35E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:3.65|P-value:1.48E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.87|P-value:6.20E-5 ID:SGTC_1336|Compound:1486-0901|FD-Score:3.16|P-value:8.12E-4 ID:SGTC_1614|Compound:st002383|FD-Score:3.12|P-value:9.42E-4 ID:SGTC_1754|Compound:st042065|FD-Score:5.33|P-value:7.75E-8 ID:SGTC_1803|Compound:st050068|FD-Score:4.25|P-value:1.33E-5 ID:SGTC_1818|Compound:st052136|FD-Score:3.55|P-value:2.15E-4 ID:SGTC_1845|Compound:st056753|FD-Score:3.61|P-value:1.70E-4 ID:SGTC_1908|Compound:st060353|FD-Score:-4.85|P-value:2.21E-6 ID:SGTC_1913|Compound:st060213|FD-Score:3.31|P-value:4.94E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.19|P-value:7.43E-4 ID:SGTC_2296|Compound:7971656|FD-Score:5.25|P-value:1.19E-7 ID:SGTC_2302|Compound:7771753|FD-Score:3.74|P-value:1.03E-4 ID:SGTC_2328|Compound:6201408|FD-Score:-4.17|P-value:4.10E-5 ID:SGTC_2378|Compound:9074213|FD-Score:3.23|P-value:6.52E-4 ID:SGTC_2404|Compound:5161160|FD-Score:-3.81|P-value:1.67E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:3.19|P-value:7.56E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-3.63|P-value:3.25E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.55|P-value:2.11E-4 ID:SGTC_2601|Compound:securinine|FD-Score:4.38|P-value:7.55E-6 ID:SGTC_2608|Compound:thymoquinone|FD-Score:8.16|P-value:7.19E-16 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.27|P-value:1.23E-5 ID:SGTC_2789|Compound:5281112|FD-Score:3.58|P-value:1.89E-4 ID:SGTC_2812|Compound:7970281|FD-Score:4.12|P-value:2.26E-5 ID:SGTC_2817|Compound:7995342|FD-Score:3.90|P-value:5.50E-5 ID:SGTC_2818|Compound:7996756|FD-Score:3.63|P-value:1.60E-4 ID:SGTC_2823|Compound:7987624|FD-Score:-5.84|P-value:1.43E-8 ID:SGTC_2967|Compound:9089538|FD-Score:3.72|P-value:1.14E-4 ID:SGTC_3045|Compound:9092950|FD-Score:-3.66|P-value:2.90E-4 ID:SGTC_3056|Compound:9094900|FD-Score:4.42|P-value:6.23E-6 ID:SGTC_3137|Compound:9097352|FD-Score:5.77|P-value:7.06E-9 ID:SGTC_3181|Compound:9108277|FD-Score:3.33|P-value:4.56E-4 ID:SGTC_3186|Compound:9110464|FD-Score:-3.32|P-value:9.17E-4 ID:SGTC_3207|Compound:9114163|FD-Score:3.22|P-value:6.80E-4 ID:SGTC_3208|Compound:9114115|FD-Score:3.62|P-value:1.66E-4

Top fitness defect scores for YPL205C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_221 trifluoperazine 10.80 10.3 µM 4.26E-26 NEO1-PIK1 48 2.41E-27
2 SGTC_2608 thymoquinone 8.16 42.7 µM 7.19E-16 3 1.64E-16
3 SGTC_3137 9097352 5.77 49.5 µM 7.06E-9 8 3.92E-9
4 SGTC_1754 st042065 5.33 16.1 µM 7.75E-8 NEO1-PIK1 112 4.87E-8
5 SGTC_2296 7971656 5.25 126.5 µM 1.19E-7 21 7.67E-8
6 SGTC_1062 mesoridazine 4.90 14.2 µM 6.88E-7 6 4.82E-7
7 SGTC_722 3534-0461 4.79 190.0 µM 1.14E-6 PDR1 21 8.20E-7
8 SGTC_625 k213-0058 4.74 121.0 µM 1.47E-6 translation 65 1.07E-6
9 SGTC_3056 9094900 4.42 49.5 µM 6.23E-6 12 4.85E-6
10 SGTC_2601 securinine 4.38 100.0 µM 7.55E-6 20 5.93E-6
11 SGTC_2688 kanamycin b 4.27 96.7 µM 1.23E-5 calcium & mitochondrial duress 325 9.87E-6
12 SGTC_1803 st050068 4.25 52.4 µM 1.33E-5 NEO1-PIK1 159 1.07E-5
13 SGTC_2812 7970281 4.12 58.4 µM 2.26E-5 24 1.86E-5
14 SGTC_740 k014-0057 3.91 261.0 µM 5.41E-5 26 4.64E-5
15 SGTC_2817 7995342 3.90 71.4 µM 5.50E-5 25 4.73E-5
16 SGTC_724 3910-0327 3.89 137.0 µM 5.94E-5 ERG2 22 5.11E-5
17 SGTC_1243 0416-0003 3.87 5.7 µM 6.20E-5 PDR1 32 5.35E-5
18 SGTC_2302 7771753 3.74 200.0 µM 1.03E-4 47 9.05E-5
19 SGTC_2967 9089538 3.72 49.9 µM 1.14E-4 42 1.01E-4
20 SGTC_1103 duloxetine 3.67 36.1 µM 1.35E-4 43 1.21E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.277 4.40E-60 YNL295W_p YNL295W_p hom Putative protein of unknown function
0.245 4.16E-47 YGL077C HNM1 hom Choline/ethanolamine transporter; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol
0.238 2.00E-44 YGR202C PCT1 hom Cholinephosphate cytidylyltransferase; a rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding; contains an element within the regulatory domain involved in both silencing and activation of enzymatic activity
0.235 3.33E-43 YNL183C NPR1 hom Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex
0.228 6.43E-41 YBR245C ISW1 hom ATPase subunit of imitation-switch (ISWI) class chromatin remodelers; ATPase; forms a complex with Ioc3p (Isw1a), and a complex with Ioc2p and Ioc4p (Isw1b); Isw1a and Isw1b have partially overlapping and distinct roles, Isw1a involved in repression of transcription initiation and Isw1b involved in regulation of transcription elongation; Isw1b recruited to open reading frames by H3K36 methylation and acts with Chd1p to prevent trans-histone exchange over coding regions
0.219 1.19E-37 YBR246W RRT2 hom Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription
0.215 2.69E-36 YOR357C SNX3 hom Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p
0.214 4.68E-36 YGR166W TRS65 hom Subunit of TRAPPII, a multimeric guanine nucleotide-exchange factor for Ypt1p; involved in intra-Golgi traffic and the retrograde pathway from the endosome to Golgi; role in cell wall beta-glucan biosynthesis and the stress response
0.210 9.90E-35 YOR115C TRS33 hom One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
0.206 2.12E-33 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.192 2.95E-29 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.184 5.11E-27 YCR095C_p OCA4_p hom Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
0.184 7.10E-27 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.183 9.42E-27 YHR108W GGA2 hom Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin
0.183 1.55E-26 YLR020C YEH2 hom Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism