YPL240C / HSP82

Hsp90 chaperone; redundant in function with Hsc82p; required for pheromone signaling, negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding, nucleotide addition; protein abundance increases in response to DNA replication stress; contains two acid-rich unstructured regions that promote solubility of chaperone-substrate complexes; HSP82 has a paralog, HSC82, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL240C / HSP82

Click on Significant Values for Screen Details ID:SGTC_403|Compound:arphamenine a|FD-Score:3.40|P-value:6.01E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.37|P-value:6.51E-4 ID:SGTC_465|Compound:cgp-37157|FD-Score:3.60|P-value:2.94E-4 ID:SGTC_720|Compound:r052-1644|FD-Score:5.29|P-value:2.07E-7 ID:SGTC_721|Compound:1187-1332|FD-Score:3.76|P-value:1.68E-4 ID:SGTC_742|Compound:0kpi-0133|FD-Score:3.93|P-value:8.60E-5 ID:SGTC_773|Compound:4358-1457|FD-Score:-3.70|P-value:1.71E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:-3.48|P-value:3.80E-4 ID:SGTC_859|Compound:0439-0102|FD-Score:4.39|P-value:1.40E-5 ID:SGTC_860|Compound:0443-0016|FD-Score:3.94|P-value:8.58E-5 ID:SGTC_921|Compound:1561-0023|FD-Score:4.75|P-value:2.86E-6 ID:SGTC_932|Compound:2857-0803|FD-Score:4.34|P-value:1.68E-5 ID:SGTC_996|Compound:3970-0799|FD-Score:3.39|P-value:6.04E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:5.29|P-value:2.14E-7 ID:SGTC_1460|Compound:k062-0059|FD-Score:4.67|P-value:4.01E-6 ID:SGTC_1510|Compound:1123-0200|FD-Score:3.74|P-value:1.82E-4 ID:SGTC_1550|Compound:gossypolone|FD-Score:3.34|P-value:7.18E-4 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:3.68|P-value:2.25E-4 ID:SGTC_1660|Compound:st012960|FD-Score:4.65|P-value:4.39E-6 ID:SGTC_1670|Compound:st016595|FD-Score:3.75|P-value:1.70E-4 ID:SGTC_1672|Compound:st016598|FD-Score:6.92|P-value:1.71E-11 ID:SGTC_1752|Compound:st044819|FD-Score:4.43|P-value:1.14E-5 ID:SGTC_1806|Compound:st050005|FD-Score:4.56|P-value:6.47E-6 ID:SGTC_1822|Compound:st052468|FD-Score:4.82|P-value:2.03E-6 ID:SGTC_1911|Compound:st060208|FD-Score:5.28|P-value:2.20E-7 ID:SGTC_1917|Compound:st066507|FD-Score:-4.48|P-value:7.53E-6 ID:SGTC_2137|Compound:5261020|FD-Score:-3.29|P-value:7.21E-4 ID:SGTC_2203|Compound:7227154|FD-Score:4.46|P-value:9.95E-6 ID:SGTC_2227|Compound:7312221|FD-Score:4.57|P-value:6.19E-6 ID:SGTC_2284|Compound:7945075|FD-Score:4.98|P-value:9.59E-7 ID:SGTC_2398|Compound:5228213|FD-Score:-5.10|P-value:4.23E-7 ID:SGTC_2511|Compound:berberine|FD-Score:4.35|P-value:1.63E-5 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.27|P-value:7.78E-4 ID:SGTC_2556|Compound:citropten|FD-Score:4.87|P-value:1.64E-6 ID:SGTC_2560|Compound:caryophyllene|FD-Score:4.21|P-value:2.86E-5 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:4.34|P-value:1.66E-5 ID:SGTC_2570|Compound:licareol|FD-Score:-3.20|P-value:9.78E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:3.29|P-value:8.60E-4 ID:SGTC_3135|Compound:9127742|FD-Score:3.63|P-value:2.65E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:3.40|P-value:6.01E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.37|P-value:6.51E-4 ID:SGTC_465|Compound:cgp-37157|FD-Score:3.60|P-value:2.94E-4 ID:SGTC_720|Compound:r052-1644|FD-Score:5.29|P-value:2.07E-7 ID:SGTC_721|Compound:1187-1332|FD-Score:3.76|P-value:1.68E-4 ID:SGTC_742|Compound:0kpi-0133|FD-Score:3.93|P-value:8.60E-5 ID:SGTC_773|Compound:4358-1457|FD-Score:-3.70|P-value:1.71E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:-3.48|P-value:3.80E-4 ID:SGTC_859|Compound:0439-0102|FD-Score:4.39|P-value:1.40E-5 ID:SGTC_860|Compound:0443-0016|FD-Score:3.94|P-value:8.58E-5 ID:SGTC_921|Compound:1561-0023|FD-Score:4.75|P-value:2.86E-6 ID:SGTC_932|Compound:2857-0803|FD-Score:4.34|P-value:1.68E-5 ID:SGTC_996|Compound:3970-0799|FD-Score:3.39|P-value:6.04E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:5.29|P-value:2.14E-7 ID:SGTC_1460|Compound:k062-0059|FD-Score:4.67|P-value:4.01E-6 ID:SGTC_1510|Compound:1123-0200|FD-Score:3.74|P-value:1.82E-4 ID:SGTC_1550|Compound:gossypolone|FD-Score:3.34|P-value:7.18E-4 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:3.68|P-value:2.25E-4 ID:SGTC_1660|Compound:st012960|FD-Score:4.65|P-value:4.39E-6 ID:SGTC_1670|Compound:st016595|FD-Score:3.75|P-value:1.70E-4 ID:SGTC_1672|Compound:st016598|FD-Score:6.92|P-value:1.71E-11 ID:SGTC_1752|Compound:st044819|FD-Score:4.43|P-value:1.14E-5 ID:SGTC_1806|Compound:st050005|FD-Score:4.56|P-value:6.47E-6 ID:SGTC_1822|Compound:st052468|FD-Score:4.82|P-value:2.03E-6 ID:SGTC_1911|Compound:st060208|FD-Score:5.28|P-value:2.20E-7 ID:SGTC_1917|Compound:st066507|FD-Score:-4.48|P-value:7.53E-6 ID:SGTC_2137|Compound:5261020|FD-Score:-3.29|P-value:7.21E-4 ID:SGTC_2203|Compound:7227154|FD-Score:4.46|P-value:9.95E-6 ID:SGTC_2227|Compound:7312221|FD-Score:4.57|P-value:6.19E-6 ID:SGTC_2284|Compound:7945075|FD-Score:4.98|P-value:9.59E-7 ID:SGTC_2398|Compound:5228213|FD-Score:-5.10|P-value:4.23E-7 ID:SGTC_2511|Compound:berberine|FD-Score:4.35|P-value:1.63E-5 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.27|P-value:7.78E-4 ID:SGTC_2556|Compound:citropten|FD-Score:4.87|P-value:1.64E-6 ID:SGTC_2560|Compound:caryophyllene|FD-Score:4.21|P-value:2.86E-5 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:4.34|P-value:1.66E-5 ID:SGTC_2570|Compound:licareol|FD-Score:-3.20|P-value:9.78E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:3.29|P-value:8.60E-4 ID:SGTC_3135|Compound:9127742|FD-Score:3.63|P-value:2.65E-4

Top fitness defect scores for YPL240C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1672 st016598 6.92 6.5 µM 1.71E-11 endomembrane recycling 23 2.22E-12
2 SGTC_720 r052-1644 5.29 49.9 µM 2.07E-7 TSC3-RPN4 11 5.98E-8
3 SGTC_1459 k035-0031 5.29 35.7 µM 2.14E-7 DNA intercalators 8 6.19E-8
4 SGTC_1911 st060208 5.28 74.3 µM 2.20E-7 11 6.39E-8
5 SGTC_2284 7945075 4.98 39.2 µM 9.59E-7 mitochondrial processes 12 3.16E-7
6 SGTC_2556 citropten 4.87 84.6 µM 1.64E-6 12 5.67E-7
7 SGTC_1822 st052468 4.82 42.0 µM 2.03E-6 3 7.12E-7
8 SGTC_921 1561-0023 4.75 372.0 µM 2.86E-6 8 1.03E-6
9 SGTC_1460 k062-0059 4.67 9.2 µM 4.01E-6 Golgi 3 1.49E-6
10 SGTC_1660 st012960 4.65 28.1 µM 4.39E-6 iron homeostasis 21 1.65E-6
11 SGTC_2227 7312221 4.57 64.1 µM 6.19E-6 1 2.39E-6
12 SGTC_1806 st050005 4.56 60.3 µM 6.47E-6 4 2.51E-6
13 SGTC_2203 7227154 4.46 166.4 µM 9.95E-6 5 4.01E-6
14 SGTC_1752 st044819 4.43 83.0 µM 1.14E-5 17 4.65E-6
15 SGTC_859 0439-0102 4.39 54.6 µM 1.40E-5 redox potentiating 13 5.79E-6
16 SGTC_2511 berberine 4.35 10.5 µM 1.63E-5 60S ribosome export 14 6.83E-6
17 SGTC_2562 3',7'-dimethoxyflavone 4.34 64.9 µM 1.66E-5 21 6.96E-6
18 SGTC_932 2857-0803 4.34 154.0 µM 1.68E-5 22 7.09E-6
19 SGTC_2560 caryophyllene 4.21 100.0 µM 2.86E-5 11 1.26E-5
20 SGTC_860 0443-0016 3.94 25.1 µM 8.58E-5 33 4.15E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.130 3.66E-14 YOR169C_d YOR169C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GLN4/YOR168W
0.102 2.88E-9 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.092 9.86E-8 YOL138C RTC1 hom Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; null mutation suppresses cdc13-1 temperature sensitivity; has N-terminal WD-40 repeats and a C-terminal RING motif
0.088 3.23E-7 YOR168W GLN4 het Glutamine tRNA synthetase, monomeric class I tRNA synthetase that catalyzes the specific glutaminylation of tRNA(Glu); N-terminal domain proposed to be involved in enzyme-tRNA interactions
0.088 3.72E-7 YNL150W_d YNL150W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; extensive overlap with PGA2/YNL149C, an uncharacterized gene with a proposed role in protein trafficking
0.087 4.77E-7 YBR171W SEC66 hom Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.087 4.88E-7 YPL168W_p YPL168W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; expression may be cell cycle-regulated
0.082 1.90E-6 YGL199C_d YGL199C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YIP4/YGL198W
0.080 3.45E-6 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.080 3.88E-6 YPL248C GAL4 hom DNA-binding transcription factor required for the activation of the GAL genes in response to galactose; repressed by Gal80p and activated by Gal3p
0.079 4.12E-6 YGL103W RPL28 het Ribosomal 60S subunit protein L28; homologous to mammalian ribosomal protein L27A and bacterial L15; may have peptidyl transferase activity; can mutate to cycloheximide resistance
0.075 1.49E-5 YJL060W BNA3 hom Kynurenine aminotransferase, catalyzes formation of kynurenic acid from kynurenine; potential Cdc28p substrate
0.074 1.68E-5 YPL038W-A_p YPL038W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.074 1.84E-5 YKL120W OAC1 hom Mitochondrial inner membrane transporter, transports oxaloacetate, sulfate, thiosulfate, and isopropylmalate; member of the mitochondrial carrier family
0.073 2.44E-5 YDR246W-A_p YDR246W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR