YPR187W / RPO26

RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPR187W / RPO26

Click on Significant Values for Screen Details ID:SGTC_193|Compound:1273-0060|FD-Score:-4.66|P-value:8.21E-5 ID:SGTC_195|Compound:4234-0266|FD-Score:4.02|P-value:4.59E-4 ID:SGTC_246|Compound:cycloheximide|FD-Score:4.06|P-value:4.11E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:5.07|P-value:1.53E-5 ID:SGTC_385|Compound:1494-0393|FD-Score:3.94|P-value:5.77E-4 ID:SGTC_480|Compound:am 92016|FD-Score:3.75|P-value:9.92E-4 ID:SGTC_529|Compound:4076-0302|FD-Score:4.43|P-value:1.33E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:5.11|P-value:1.32E-5 ID:SGTC_695|Compound:3505-6186|FD-Score:4.34|P-value:1.74E-4 ID:SGTC_724|Compound:3910-0327|FD-Score:4.05|P-value:4.21E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:3.82|P-value:8.17E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:4.55|P-value:9.06E-5 ID:SGTC_986|Compound:1493-0483|FD-Score:-3.93|P-value:7.64E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:-3.89|P-value:8.56E-4 ID:SGTC_1104|Compound:tacrolimus|FD-Score:-4.14|P-value:4.19E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:-4.07|P-value:5.13E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:3.96|P-value:5.56E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:-4.36|P-value:2.17E-4 ID:SGTC_1519|Compound:esterone|FD-Score:-4.97|P-value:2.97E-5 ID:SGTC_1569|Compound:carminic acid|FD-Score:-4.75|P-value:6.20E-5 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:4.16|P-value:3.08E-4 ID:SGTC_1607|Compound:st000305|FD-Score:4.19|P-value:2.78E-4 ID:SGTC_1764|Compound:st044502|FD-Score:-5.78|P-value:1.46E-6 ID:SGTC_1766|Compound:st045414|FD-Score:-4.39|P-value:1.97E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-6.07|P-value:4.48E-7 ID:SGTC_1845|Compound:st056753|FD-Score:5.32|P-value:6.19E-6 ID:SGTC_1856|Compound:st057054|FD-Score:5.08|P-value:1.50E-5 ID:SGTC_1873|Compound:rapamycin|FD-Score:3.97|P-value:5.31E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:-4.83|P-value:4.69E-5 ID:SGTC_1884|Compound:5633444|FD-Score:-4.67|P-value:7.91E-5 ID:SGTC_1909|Compound:st060837|FD-Score:-5.40|P-value:6.16E-6 ID:SGTC_1945|Compound:st075991|FD-Score:4.60|P-value:7.57E-5 ID:SGTC_1999|Compound:st074831|FD-Score:-4.06|P-value:5.22E-4 ID:SGTC_2011|Compound:4012611|FD-Score:-4.20|P-value:3.51E-4 ID:SGTC_2034|Compound:5197015|FD-Score:-3.94|P-value:7.35E-4 ID:SGTC_2060|Compound:5238662|FD-Score:4.07|P-value:4.03E-4 ID:SGTC_2068|Compound:5226020|FD-Score:-3.83|P-value:9.91E-4 ID:SGTC_2109|Compound:5483026|FD-Score:4.23|P-value:2.49E-4 ID:SGTC_2114|Compound:5491910|FD-Score:-4.02|P-value:5.83E-4 ID:SGTC_2182|Compound:6325192|FD-Score:-5.13|P-value:1.64E-5 ID:SGTC_2187|Compound:6125751|FD-Score:3.84|P-value:7.84E-4 ID:SGTC_2242|Compound:6630449|FD-Score:4.11|P-value:3.53E-4 ID:SGTC_2350|Compound:9023895|FD-Score:-4.26|P-value:2.88E-4 ID:SGTC_2437|Compound:5741531|FD-Score:-4.42|P-value:1.81E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:-3.90|P-value:8.30E-4 ID:SGTC_2805|Compound:7950783|FD-Score:-4.07|P-value:5.06E-4 ID:SGTC_2881|Compound:9058953|FD-Score:-4.55|P-value:1.20E-4 ID:SGTC_2900|Compound:5328528|FD-Score:-5.40|P-value:6.31E-6 ID:SGTC_2909|Compound:7941780|FD-Score:4.01|P-value:4.75E-4 ID:SGTC_2921|Compound:7974240|FD-Score:3.90|P-value:6.59E-4 ID:SGTC_2926|Compound:9010726|FD-Score:-5.51|P-value:4.17E-6 ID:SGTC_2968|Compound:9090663|FD-Score:-4.71|P-value:6.98E-5 ID:SGTC_2989|Compound:9073649|FD-Score:5.37|P-value:5.19E-6 ID:SGTC_2996|Compound:9066192|FD-Score:5.09|P-value:1.41E-5 ID:SGTC_3020|Compound:9089140|FD-Score:4.36|P-value:1.67E-4 ID:SGTC_3085|Compound:9117376|FD-Score:-4.64|P-value:8.95E-5 ID:SGTC_3125|Compound:9127534|FD-Score:-3.93|P-value:7.51E-4 ID:SGTC_3126|Compound:9127922|FD-Score:-4.26|P-value:2.91E-4 ID:SGTC_3141|Compound:9094609|FD-Score:-3.85|P-value:9.42E-4 ID:SGTC_3142|Compound:9086498|FD-Score:-4.63|P-value:9.28E-5 ID:SGTC_3219|Compound:9131112|FD-Score:-4.34|P-value:2.28E-4 ID:SGTC_3243|Compound:9134147|FD-Score:-4.25|P-value:3.04E-4 ID:SGTC_3252|Compound:9135871|FD-Score:4.45|P-value:1.25E-4 ID:SGTC_3329|Compound:9141233|FD-Score:-4.41|P-value:1.85E-4 ID:SGTC_193|Compound:1273-0060|FD-Score:-4.66|P-value:8.21E-5 ID:SGTC_195|Compound:4234-0266|FD-Score:4.02|P-value:4.59E-4 ID:SGTC_246|Compound:cycloheximide|FD-Score:4.06|P-value:4.11E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:5.07|P-value:1.53E-5 ID:SGTC_385|Compound:1494-0393|FD-Score:3.94|P-value:5.77E-4 ID:SGTC_480|Compound:am 92016|FD-Score:3.75|P-value:9.92E-4 ID:SGTC_529|Compound:4076-0302|FD-Score:4.43|P-value:1.33E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:5.11|P-value:1.32E-5 ID:SGTC_695|Compound:3505-6186|FD-Score:4.34|P-value:1.74E-4 ID:SGTC_724|Compound:3910-0327|FD-Score:4.05|P-value:4.21E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:3.82|P-value:8.17E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:4.55|P-value:9.06E-5 ID:SGTC_986|Compound:1493-0483|FD-Score:-3.93|P-value:7.64E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:-3.89|P-value:8.56E-4 ID:SGTC_1104|Compound:tacrolimus|FD-Score:-4.14|P-value:4.19E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:-4.07|P-value:5.13E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:3.96|P-value:5.56E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:-4.36|P-value:2.17E-4 ID:SGTC_1519|Compound:esterone|FD-Score:-4.97|P-value:2.97E-5 ID:SGTC_1569|Compound:carminic acid|FD-Score:-4.75|P-value:6.20E-5 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:4.16|P-value:3.08E-4 ID:SGTC_1607|Compound:st000305|FD-Score:4.19|P-value:2.78E-4 ID:SGTC_1764|Compound:st044502|FD-Score:-5.78|P-value:1.46E-6 ID:SGTC_1766|Compound:st045414|FD-Score:-4.39|P-value:1.97E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-6.07|P-value:4.48E-7 ID:SGTC_1845|Compound:st056753|FD-Score:5.32|P-value:6.19E-6 ID:SGTC_1856|Compound:st057054|FD-Score:5.08|P-value:1.50E-5 ID:SGTC_1873|Compound:rapamycin|FD-Score:3.97|P-value:5.31E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:-4.83|P-value:4.69E-5 ID:SGTC_1884|Compound:5633444|FD-Score:-4.67|P-value:7.91E-5 ID:SGTC_1909|Compound:st060837|FD-Score:-5.40|P-value:6.16E-6 ID:SGTC_1945|Compound:st075991|FD-Score:4.60|P-value:7.57E-5 ID:SGTC_1999|Compound:st074831|FD-Score:-4.06|P-value:5.22E-4 ID:SGTC_2011|Compound:4012611|FD-Score:-4.20|P-value:3.51E-4 ID:SGTC_2034|Compound:5197015|FD-Score:-3.94|P-value:7.35E-4 ID:SGTC_2060|Compound:5238662|FD-Score:4.07|P-value:4.03E-4 ID:SGTC_2068|Compound:5226020|FD-Score:-3.83|P-value:9.91E-4 ID:SGTC_2109|Compound:5483026|FD-Score:4.23|P-value:2.49E-4 ID:SGTC_2114|Compound:5491910|FD-Score:-4.02|P-value:5.83E-4 ID:SGTC_2182|Compound:6325192|FD-Score:-5.13|P-value:1.64E-5 ID:SGTC_2187|Compound:6125751|FD-Score:3.84|P-value:7.84E-4 ID:SGTC_2242|Compound:6630449|FD-Score:4.11|P-value:3.53E-4 ID:SGTC_2350|Compound:9023895|FD-Score:-4.26|P-value:2.88E-4 ID:SGTC_2437|Compound:5741531|FD-Score:-4.42|P-value:1.81E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:-3.90|P-value:8.30E-4 ID:SGTC_2805|Compound:7950783|FD-Score:-4.07|P-value:5.06E-4 ID:SGTC_2881|Compound:9058953|FD-Score:-4.55|P-value:1.20E-4 ID:SGTC_2900|Compound:5328528|FD-Score:-5.40|P-value:6.31E-6 ID:SGTC_2909|Compound:7941780|FD-Score:4.01|P-value:4.75E-4 ID:SGTC_2921|Compound:7974240|FD-Score:3.90|P-value:6.59E-4 ID:SGTC_2926|Compound:9010726|FD-Score:-5.51|P-value:4.17E-6 ID:SGTC_2968|Compound:9090663|FD-Score:-4.71|P-value:6.98E-5 ID:SGTC_2989|Compound:9073649|FD-Score:5.37|P-value:5.19E-6 ID:SGTC_2996|Compound:9066192|FD-Score:5.09|P-value:1.41E-5 ID:SGTC_3020|Compound:9089140|FD-Score:4.36|P-value:1.67E-4 ID:SGTC_3085|Compound:9117376|FD-Score:-4.64|P-value:8.95E-5 ID:SGTC_3125|Compound:9127534|FD-Score:-3.93|P-value:7.51E-4 ID:SGTC_3126|Compound:9127922|FD-Score:-4.26|P-value:2.91E-4 ID:SGTC_3141|Compound:9094609|FD-Score:-3.85|P-value:9.42E-4 ID:SGTC_3142|Compound:9086498|FD-Score:-4.63|P-value:9.28E-5 ID:SGTC_3219|Compound:9131112|FD-Score:-4.34|P-value:2.28E-4 ID:SGTC_3243|Compound:9134147|FD-Score:-4.25|P-value:3.04E-4 ID:SGTC_3252|Compound:9135871|FD-Score:4.45|P-value:1.25E-4 ID:SGTC_3329|Compound:9141233|FD-Score:-4.41|P-value:1.85E-4

Top fitness defect scores for YPR187W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2989 9073649 5.37 71.4 µM 5.19E-6 3 4.03E-8 0.80
2 SGTC_1845 st056753 5.32 3.0 µM 6.19E-6 TSC3-RPN4 2 5.22E-8 0.20
3 SGTC_549 1661-1316 5.11 519.0 µM 1.32E-5 2 1.58E-7 0.46
4 SGTC_2996 9066192 5.09 71.4 µM 1.41E-5 3 1.76E-7 0.60
5 SGTC_1856 st057054 5.08 55.7 µM 1.50E-5 1 1.92E-7 1.12
6 SGTC_274 sirtinol 5.07 40.1 µM 1.53E-5 9 1.98E-7 0.18
7 SGTC_1945 st075991 4.60 56.6 µM 7.57E-5 60S ribosome export 5 2.06E-6 0.36
8 SGTC_964 1287-0107 4.55 19.4 µM 9.06E-5 cell wall 15 2.68E-6 0.03
9 SGTC_3252 9135871 4.45 49.5 µM 1.25E-4 4 4.32E-6 0.35
10 SGTC_529 4076-0302 4.43 30.3 µM 1.33E-4 mitochondrial processes 5 4.71E-6 0.33
11 SGTC_3020 9089140 4.36 49.5 µM 1.67E-4 8 6.57E-6 0.39
12 SGTC_695 3505-6186 4.34 243.0 µM 1.74E-4 5 7.00E-6 0.06
13 SGTC_2109 5483026 4.23 200.0 µM 2.49E-4 RSC complex & mRNA processing 32 1.18E-5 0.18
14 SGTC_1607 st000305 4.19 50.6 µM 2.78E-4 3 1.38E-5 0.09
15 SGTC_1576 erythromycin ethylsuccinate 4.16 23.2 µM 3.08E-4 4 1.61E-5 0.03
16 SGTC_2242 6630449 4.11 61.3 µM 3.53E-4 Golgi 4 1.95E-5 0.35
17 SGTC_2060 5238662 4.07 140.0 µM 4.03E-4 2 2.37E-5 0.05
18 SGTC_246 cycloheximide 4.06 667.0 µM 4.11E-4 9 2.44E-5 0.15
19 SGTC_724 3910-0327 4.05 137.0 µM 4.21E-4 ERG2 3 2.53E-5 0.11
20 SGTC_195 4234-0266 4.02 16.6 µM 4.59E-4 11 2.87E-5 0.10

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.190 1.07E-28 YHR143W-A RPC10 het RNA polymerase subunit ABC10-alpha, found in RNA pol I, II, and III; relocalizes from nucleolus to cytoplasm upon DNA replication stress
0.148 5.81E-18 YDR404C RPB7 het RNA polymerase II subunit B16; forms two subunit dissociable complex with Rpb4p; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex and in export of mRNA to cytoplasm under stress conditions; also involved in translation initiation
0.123 8.42E-13 YML127W RSC9 het Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway
0.114 4.19E-11 YIL021W RPB3 het RNA polymerase II third largest subunit B44, part of central core; similar to prokaryotic alpha subunit
0.104 1.55E-9 YBR091C TIM12 het Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins
0.096 2.28E-8 YBR154C RPB5 het RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III; contacts DNA and affects transactivation
0.094 4.47E-8 YDR527W RBA50 het Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1
0.093 5.94E-8 YDL150W RPC53 het RNA polymerase III subunit C53
0.092 9.76E-8 YDL152W_d YDL152W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SAS10/YDL153C, a component of the small ribosomal subunit processosome
0.091 1.18E-7 YDL193W NUS1 het Putative prenyltransferase, required for cell viability; proposed to be involved in protein trafficking because tet-repressible mutant shows accumulation of hypoglycosylated forms of CPY
0.087 4.31E-7 YFR037C RSC8 het Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters
0.086 6.56E-7 YHR183W GND1 hom 6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone and adaptation to oxidative stress; GND1 has a paralog, GND2, that arose from the whole genome duplication
0.085 8.75E-7 YFL023W BUD27 hom Unconventional prefoldin protein involved in translation initiation; mutants have inappropriate expression of nutrient sensitive genes due to translational derepression of Gcn4p transcription factor; diploid mutants show random budding; ortholog of human URI/RMP
0.083 1.28E-6 YER165W PAB1 het Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G
0.083 1.57E-6 YDR449C UTP6 het Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA