YPR193C / HPA2

Tetrameric histone acetyltransferase with similarity to Gcn5p, Hat1p, Elp3p, and Hpa3p; acetylates histones H3 and H4 in vitro and exhibits autoacetylation activity

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR193C / HPA2

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:3.22|P-value:3.65E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:-3.79|P-value:4.43E-5 ID:SGTC_125|Compound:0133-0007|FD-Score:3.37|P-value:2.04E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:3.33|P-value:2.47E-4 ID:SGTC_230|Compound:MPP+|FD-Score:4.84|P-value:2.10E-7 ID:SGTC_323|Compound:4013-0906|FD-Score:3.20|P-value:3.96E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:-3.19|P-value:4.88E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:3.61|P-value:7.81E-5 ID:SGTC_360|Compound:0957-0399|FD-Score:3.55|P-value:1.02E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:3.50|P-value:1.23E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:3.44|P-value:1.58E-4 ID:SGTC_456|Compound:gingerol|FD-Score:2.97|P-value:9.40E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:3.15|P-value:4.80E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:3.06|P-value:6.71E-4 ID:SGTC_587|Compound:k089-0003|FD-Score:3.99|P-value:1.48E-5 ID:SGTC_674|Compound:0498-0004|FD-Score:3.56|P-value:9.73E-5 ID:SGTC_678|Compound:1218-2179|FD-Score:4.06|P-value:1.07E-5 ID:SGTC_684|Compound:1140-0066|FD-Score:3.72|P-value:5.02E-5 ID:SGTC_993|Compound:3909-8757|FD-Score:3.86|P-value:2.69E-5 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-4.72|P-value:4.92E-7 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.71|P-value:5.15E-5 ID:SGTC_1322|Compound:1348-1070|FD-Score:3.43|P-value:1.65E-4 ID:SGTC_1985|Compound:st071382|FD-Score:3.10|P-value:5.74E-4 ID:SGTC_2030|Compound:5175110|FD-Score:3.21|P-value:3.86E-4 ID:SGTC_2032|Compound:5185112|FD-Score:3.58|P-value:9.05E-5 ID:SGTC_2034|Compound:5197015|FD-Score:4.62|P-value:6.67E-7 ID:SGTC_2127|Compound:5253358|FD-Score:3.58|P-value:8.90E-5 ID:SGTC_2149|Compound:5554786|FD-Score:3.94|P-value:1.84E-5 ID:SGTC_2238|Compound:6671620|FD-Score:2.98|P-value:8.84E-4 ID:SGTC_2333|Compound:9017922|FD-Score:-4.16|P-value:8.16E-6 ID:SGTC_2469|Compound:5655019|FD-Score:3.68|P-value:5.76E-5 ID:SGTC_2472|Compound:5377652|FD-Score:4.11|P-value:8.53E-6 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.55|P-value:1.02E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:3.29|P-value:2.79E-4 ID:SGTC_2782|Compound:7736369|FD-Score:3.41|P-value:1.75E-4 ID:SGTC_2825|Compound:7998094|FD-Score:7.68|P-value:5.40E-16 ID:SGTC_2826|Compound:7992541|FD-Score:-4.90|P-value:1.88E-7 ID:SGTC_2827|Compound:7993847|FD-Score:5.78|P-value:7.76E-10 ID:SGTC_2828|Compound:7998861|FD-Score:2.98|P-value:8.78E-4 ID:SGTC_2831|Compound:7999036|FD-Score:-3.00|P-value:9.84E-4 ID:SGTC_2835|Compound:9006588|FD-Score:-5.02|P-value:9.58E-8 ID:SGTC_2841|Compound:9004761|FD-Score:3.09|P-value:5.92E-4 ID:SGTC_3068|Compound:9116768|FD-Score:-3.16|P-value:5.43E-4 ID:SGTC_3123|Compound:9126162|FD-Score:3.76|P-value:4.16E-5 ID:SGTC_3129|Compound:9127257|FD-Score:3.29|P-value:2.80E-4 ID:SGTC_3136|Compound:9095672|FD-Score:5.88|P-value:3.93E-10 ID:SGTC_3153|Compound:9100258|FD-Score:4.93|P-value:1.25E-7 ID:SGTC_3170|Compound:9103054|FD-Score:3.48|P-value:1.32E-4 ID:SGTC_3242|Compound:9133940|FD-Score:4.03|P-value:1.22E-5 ID:SGTC_3252|Compound:9135871|FD-Score:3.08|P-value:6.13E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.22|P-value:3.65E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:-3.79|P-value:4.43E-5 ID:SGTC_125|Compound:0133-0007|FD-Score:3.37|P-value:2.04E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:3.33|P-value:2.47E-4 ID:SGTC_230|Compound:MPP+|FD-Score:4.84|P-value:2.10E-7 ID:SGTC_323|Compound:4013-0906|FD-Score:3.20|P-value:3.96E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:-3.19|P-value:4.88E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:3.61|P-value:7.81E-5 ID:SGTC_360|Compound:0957-0399|FD-Score:3.55|P-value:1.02E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:3.50|P-value:1.23E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:3.44|P-value:1.58E-4 ID:SGTC_456|Compound:gingerol|FD-Score:2.97|P-value:9.40E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:3.15|P-value:4.80E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:3.06|P-value:6.71E-4 ID:SGTC_587|Compound:k089-0003|FD-Score:3.99|P-value:1.48E-5 ID:SGTC_674|Compound:0498-0004|FD-Score:3.56|P-value:9.73E-5 ID:SGTC_678|Compound:1218-2179|FD-Score:4.06|P-value:1.07E-5 ID:SGTC_684|Compound:1140-0066|FD-Score:3.72|P-value:5.02E-5 ID:SGTC_993|Compound:3909-8757|FD-Score:3.86|P-value:2.69E-5 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-4.72|P-value:4.92E-7 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.71|P-value:5.15E-5 ID:SGTC_1322|Compound:1348-1070|FD-Score:3.43|P-value:1.65E-4 ID:SGTC_1985|Compound:st071382|FD-Score:3.10|P-value:5.74E-4 ID:SGTC_2030|Compound:5175110|FD-Score:3.21|P-value:3.86E-4 ID:SGTC_2032|Compound:5185112|FD-Score:3.58|P-value:9.05E-5 ID:SGTC_2034|Compound:5197015|FD-Score:4.62|P-value:6.67E-7 ID:SGTC_2127|Compound:5253358|FD-Score:3.58|P-value:8.90E-5 ID:SGTC_2149|Compound:5554786|FD-Score:3.94|P-value:1.84E-5 ID:SGTC_2238|Compound:6671620|FD-Score:2.98|P-value:8.84E-4 ID:SGTC_2333|Compound:9017922|FD-Score:-4.16|P-value:8.16E-6 ID:SGTC_2469|Compound:5655019|FD-Score:3.68|P-value:5.76E-5 ID:SGTC_2472|Compound:5377652|FD-Score:4.11|P-value:8.53E-6 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.55|P-value:1.02E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:3.29|P-value:2.79E-4 ID:SGTC_2782|Compound:7736369|FD-Score:3.41|P-value:1.75E-4 ID:SGTC_2825|Compound:7998094|FD-Score:7.68|P-value:5.40E-16 ID:SGTC_2826|Compound:7992541|FD-Score:-4.90|P-value:1.88E-7 ID:SGTC_2827|Compound:7993847|FD-Score:5.78|P-value:7.76E-10 ID:SGTC_2828|Compound:7998861|FD-Score:2.98|P-value:8.78E-4 ID:SGTC_2831|Compound:7999036|FD-Score:-3.00|P-value:9.84E-4 ID:SGTC_2835|Compound:9006588|FD-Score:-5.02|P-value:9.58E-8 ID:SGTC_2841|Compound:9004761|FD-Score:3.09|P-value:5.92E-4 ID:SGTC_3068|Compound:9116768|FD-Score:-3.16|P-value:5.43E-4 ID:SGTC_3123|Compound:9126162|FD-Score:3.76|P-value:4.16E-5 ID:SGTC_3129|Compound:9127257|FD-Score:3.29|P-value:2.80E-4 ID:SGTC_3136|Compound:9095672|FD-Score:5.88|P-value:3.93E-10 ID:SGTC_3153|Compound:9100258|FD-Score:4.93|P-value:1.25E-7 ID:SGTC_3170|Compound:9103054|FD-Score:3.48|P-value:1.32E-4 ID:SGTC_3242|Compound:9133940|FD-Score:4.03|P-value:1.22E-5 ID:SGTC_3252|Compound:9135871|FD-Score:3.08|P-value:6.13E-4

Top fitness defect scores for YPR193C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2825 7998094 7.68 58.4 µM 5.40E-16 fatty acid desaturase (OLE1) 4 7.87E-15
2 SGTC_3136 9095672 5.88 49.5 µM 3.93E-10 2 1.99E-9
3 SGTC_2827 7993847 5.78 71.4 µM 7.76E-10 3 3.73E-9
4 SGTC_3153 9100258 4.93 49.5 µM 1.25E-7 6 4.04E-7
5 SGTC_230 MPP+ 4.84 141.7 µM 2.10E-7 6 6.50E-7
6 SGTC_2034 5197015 4.62 53.1 µM 6.67E-7 SWF1 & branched chain AA biosynthesis 13 1.89E-6
7 SGTC_2472 5377652 4.11 49.4 µM 8.53E-6 TRP & mitochondrial translation 49 1.98E-5
8 SGTC_678 1218-2179 4.06 85.9 µM 1.07E-5 RNA pol III & RNase P/MRP 5 2.44E-5
9 SGTC_3242 9133940 4.03 49.5 µM 1.22E-5 10 2.75E-5
10 SGTC_587 k089-0003 3.99 57.0 µM 1.48E-5 6 3.29E-5
11 SGTC_2149 5554786 3.94 194.8 µM 1.84E-5 cell wall signaling 38 4.02E-5
12 SGTC_993 3909-8757 3.86 62.7 µM 2.69E-5 28 5.71E-5
13 SGTC_3123 9126162 3.76 49.5 µM 4.16E-5 22 8.54E-5
14 SGTC_684 1140-0066 3.72 328.0 µM 5.02E-5 Golgi 33 1.01E-4
15 SGTC_1135 dihydrocapsaicin 3.71 536.7 nM 5.15E-5 43 1.04E-4
16 SGTC_2469 5655019 3.68 90.8 µM 5.76E-5 27 1.15E-4
17 SGTC_354 2783-3500 3.61 4.9 µM 7.81E-5 cell wall 58 1.53E-4
18 SGTC_2127 5253358 3.58 187.9 µM 8.90E-5 34 1.72E-4
19 SGTC_2032 5185112 3.58 26.0 µM 9.05E-5 14 1.75E-4
20 SGTC_674 0498-0004 3.56 451.0 µM 9.73E-5 heme requiring 34 1.87E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.107 5.80E-10 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.103 2.11E-9 YCR086W CSM1 hom Nucleolar protein that forms a complex with Lrs4p and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation
0.097 1.79E-8 YGR282C BGL2 hom Endo-beta-1,3-glucanase, major protein of the cell wall, involved in cell wall maintenance
0.096 2.53E-8 YLR444C_d YLR444C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.095 3.37E-8 YPL034W_p YPL034W_p hom Putative protein of unknown function; YPL034W is not essential gene
0.094 5.23E-8 YKL162C-A_d YKL162C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.093 7.51E-8 YLR150W STM1 hom Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery
0.092 1.05E-7 YIL076W SEC28 hom Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; stabilizes Cop1p, the alpha-COP and the coatomer complex; non-essential for cell growth; protein abundance increases in response to DNA replication stress
0.092 1.07E-7 YLR008C PAM18 het Constituent of the import motor (PAM complex) component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); essential J-protein cochaperone that stimulates Ssc1p ATPase activity to drive import; inhibited by Pam16p
0.091 1.18E-7 YOR208W PTP2 hom Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the nucleus
0.087 4.25E-7 YDR158W HOM2 hom Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.087 4.67E-7 YKL033W-A_p YKL033W-A_p hom Putative protein of unknown function; similar to uncharacterized proteins from other fungi
0.085 7.42E-7 YDR149C_d YDR149C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene NUM1; null mutation blocks anaerobic growth
0.084 1.17E-6 YPL163C SVS1 hom Cell wall and vacuolar protein; required for wild-type resistance to vanadate; SVS1 has a paralog, SRL1, that arose from the whole genome duplication
0.080 3.30E-6 YPR185W ATG13 hom Regulatory subunit of the Atg1p signaling complex; stimulates Atg1p kinase activity; required for vesicle formation during autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; involved in Atg9p, Atg23p, and Atg27p cycling