Major Responses

The major response signatures can be explored in detail in the network of response signatures (i.e. a web version of fig. 2).
GO TO network of response signatures

Major response signatures and their associated screens are indicated below (click on arrow to view screens).

Response SignatureDescriptionNumber
60S ribosome export LSG1-NMD3 mediated ribosomal export from the nucleus 102
amide catabolism responses associated with DAL81, a nitrogen catabolite activator 32
anthracycline transcription coupled DNA repair responses associated with SSL2, a member of RNA polymerase transcription factor TFIIH holoenzyme, and DNA damage 7
azole & statin sterol biosynthesis, induced by ergosterol pathway inhibitors such as azoles and statins 26
calcium & mitochondrial duress calcium stress response, includes IMP2', a transcriptional activator involved in ion homeostasis 38
cell wall regulation of cell wall organization 31
cell wall signaling protein kinase C signaling 25
copper-dependent oxidative stress copper transport induced by oxidative stress and copper-dependent SOD1, SOD2 25
DNA damage response DNA damage and repair 34
DNA intercalators responses associated with ERG12 (ergosterol biosynthesis), YMR166C (potential mitochondrial carrier), EFM1 (lysine methyltransferase of eIF1A) and CEP3 (kineticore protein) 27
endomembrane recycling responses associated with RCY1, a protein involved in recycling plasma membrane proteins, and (amino)phospholipid transport 31
ERAD & cell cycle endoplasmic reticulum-associated degradation and cell cycle 11
ERG2 responses associated with ERG2, involved in ergosterol biosynthesis; deletion increases membrane permeability; no other signature genes 49
ergosterol biosynthesis ergosterol biosynthesis 20
ergosterol depletion effects on membrane effects of high concentrations of ergosterol inhibitors on plasma membrane (e.g. vesicular trafficking, sterol biosynthesis) and regulation of GTPase activity 15
excess fatty acid response to excess fatty acid, primarily through LRO1, an acyltransferase that catalyzes diacylglycerol esterification 9
exosome exosome complex; induced by uracil analogs such as 5-fluorouracil 7
fatty acid desaturase (OLE1) responses associated with drug-induced happloinsufficiency of OLE1 (fatty acid desaturase) 36
Golgi intra-Golgi transport involving the COG1-8 Golgi transport complex 71
heat shock/prefoldin responses associated with the prefoldin complex, induced by heat shock 5
heme biosynthesis & mitochondrial translocase heme biosynthesis and the mitchondrial outer membrane translocase complex 19
heme requiring responses associated with heme biosynthesis, induced by compounds such as the iron chelator bathophenantroline 14
iron homeostasis responses associated with iron homeostasis, induced by several iron chelators 35
mitochondrial processes responses associated with mitochondrial processes including ATPase inhibition 53
Screen IDConditionsConcentrationPubchem CID
SGTC_11453546-059710.2 µM875334
SGTC_120rhodamine 6G52.26 µM65211
SGTC_13712421-000832.7 µM2827552
SGTC_13873342-11661.8 µM3418228
SGTC_13963511-000798.6 µM
SGTC_1567st06930368.4 µM5581319
SGTC_1583clindamycin39.6 µM32603
SGTC_15846-fluoro-dl-tryptophan90 µM94937
SGTC_1591genipin88.4 µM442424
SGTC_1641st00929947.1 µM4046054
SGTC_1644st01013420.9 µM3818134
SGTC_1686st019653115.5 µM97252
SGTC_1722st0343043.65 µM4036148
SGTC_1723st0343072.55 µM867466
SGTC_1897st06020115 µM611878
SGTC_1992st07364323.3 µM3161292
SGTC_2001402350257.66 µM108941
SGTC_20024023503131 µM4736863
SGTC_20114012611177 µM2049887
SGTC_2176580977433.97 µM2870539
SGTC_21836420625130.51 µM2897619
SGTC_21886126565140.68 µM874518
SGTC_21996590217200 µM703109
SGTC_22567954252200 µM2972920
SGTC_2284794507539.21 µM1245402
SGTC_23266164455177.58 µM2888790
SGTC_2348902254333.42 µM3162678
SGTC_23709071495200 µM21791103
SGTC_23759072683200 µM16798029
SGTC_2410aloe-emodin-8-o-glycoside46.3 µM14077415
SGTC_2418pentamidine31.67 µM4735
SGTC_245958111579.22 µM2870684
SGTC_2471546695624.79 µM724419
SGTC_2475581272815.03 µM776160
SGTC_2630antimycin a100 µM5702199
SGTC_2640pentamidine10.38 µM4735
SGTC_2676harmalol100 µM5459187
SGTC_2718lomofungin53.02 µM5351222
SGTC_2727riluzole51.77 µM5070
SGTC_3192911036249.47 µM16649480
SGTC_3196911189149.47 µM18891510
SGTC_3198911201949.47 µM45595555
SGTC_493zm226600134 µM5240098
SGTC_509pifithrin175 µM4817
SGTC_5294076-030230.3 µM5816522
SGTC_534k292-078863.4 µM4146317
SGTC_690096-0274206.68 µM6741392
SGTC_7301436-005241.2 µM768764
SGTC_7450469-0705296 µM3486736
SGTC_8510394-0702453 µM762646
SGTC_8800833-048787.2 µM76075
SGTC_9113456-4043236 µM914281
SGTC_9691313-0238134 µM5212874

mitochondrial response to ROS responses associated with mitochondrial genome maintenance, induced by compounds such as the antioxidant mangostin, which may participate in redox cycling 16
mitochondrial stress disruption of mitochondrial processes, associated with charged and reactive compounds 10
NEO1 notable drug-induced haploinsufficiency of NEO1, an aminophospholipid plasma membrane flippase 21
NEO1-PIK1 drug-induced haploinsufficiency of NEO1 (aminophospholipid plasma membrane flippase) and PIK1 (phosphatidylinositol 4-kinase) 17
PDR1 notable requirement for PDR1, a transcription factor that regulates the pleiotropic drug response; no other signature genes 26
plasma membrane duress piperazine-induced plasma membrane duress 18
redox potentiating protein catabolism via the multivesicular body sorting pathway associated with the generation of superoxide 27
RNA pol III & RNase P/MRP responses associated with RNA polymerase III and other complexes 17
RNA processing & uracil transport strong requirement for FUR4, a uracil transporter, and RNA processing genes GLC7 and RRP45; no other signature genes 29
RPP1 & pyrimidine depletion notable drug-induced haploinsufficiency of RPP1, a member of RNase P and MRP, complexes that cleave rRNA and tRNA precursors, respectively 85
RSC & ERG11 RSC chromatin structure remodeling complex and ERG11, an ergosterol biosynthesis enzyme 16
RSC complex & mRNA processing RSC chromatin structure remodeling complex and mRNA processing 24
sphingolipid biosynthesis & PDR1 responses associated with sphingolipid biosynthesis and PDR1, a transcription factor that regulates the pleiotropic drug response (induced by surfactants) 14
superoxide pentose phosphate pathway/NADP metabolism 13
SWF1 & branched chain AA biosynthesis branched chain amino acid biosynthesis and protein modification via SWF1 9
translation cytoplasmic and mitochondrial translation 6
TRP & mitochondrial translation thiazolidinone targeting of protein prenylation (RER2) dirupts mitochondrial function 14
TSC3-RPN4 responses associated with a strong requirement for TSC3 (activator of sphingolipid biosynthesis) and a moderate requirement for RPN4 (transcription factor that stimulates expression of proteasome genes) 59
tubulin folding & SWR complex tubulin biogenesis, induced by tubulin inhibitors benomyl and nocodazole 26
ubiquinone biosynthesis & proteasome responses associated with the 20S proteosome, ubiquinone biosynthesis and an adamantyl structure moiety 18
unfolded protein response unfolded protein response induced by inhibition of diverse HIP targets 11