Major Responses

The major response signatures can be explored in detail in the network of response signatures (i.e. a web version of fig. 2).
GO TO network of response signatures

Major response signatures and their associated screens are indicated below (click on arrow to view screens).

Response SignatureDescriptionNumber
60S ribosome export LSG1-NMD3 mediated ribosomal export from the nucleus 102
amide catabolism responses associated with DAL81, a nitrogen catabolite activator 32
anthracycline transcription coupled DNA repair responses associated with SSL2, a member of RNA polymerase transcription factor TFIIH holoenzyme, and DNA damage 7
azole & statin sterol biosynthesis, induced by ergosterol pathway inhibitors such as azoles and statins 26
calcium & mitochondrial duress calcium stress response, includes IMP2', a transcriptional activator involved in ion homeostasis 38
cell wall regulation of cell wall organization 31
cell wall signaling protein kinase C signaling 25
copper-dependent oxidative stress copper transport induced by oxidative stress and copper-dependent SOD1, SOD2 25
DNA damage response DNA damage and repair 34
DNA intercalators responses associated with ERG12 (ergosterol biosynthesis), YMR166C (potential mitochondrial carrier), EFM1 (lysine methyltransferase of eIF1A) and CEP3 (kineticore protein) 27
endomembrane recycling responses associated with RCY1, a protein involved in recycling plasma membrane proteins, and (amino)phospholipid transport 31
ERAD & cell cycle endoplasmic reticulum-associated degradation and cell cycle 11
ERG2 responses associated with ERG2, involved in ergosterol biosynthesis; deletion increases membrane permeability; no other signature genes 49
ergosterol biosynthesis ergosterol biosynthesis 20
ergosterol depletion effects on membrane effects of high concentrations of ergosterol inhibitors on plasma membrane (e.g. vesicular trafficking, sterol biosynthesis) and regulation of GTPase activity 15
excess fatty acid response to excess fatty acid, primarily through LRO1, an acyltransferase that catalyzes diacylglycerol esterification 9
exosome exosome complex; induced by uracil analogs such as 5-fluorouracil 7
fatty acid desaturase (OLE1) responses associated with drug-induced happloinsufficiency of OLE1 (fatty acid desaturase) 36
Golgi intra-Golgi transport involving the COG1-8 Golgi transport complex 71
heat shock/prefoldin responses associated with the prefoldin complex, induced by heat shock 5
heme biosynthesis & mitochondrial translocase heme biosynthesis and the mitchondrial outer membrane translocase complex 19
heme requiring responses associated with heme biosynthesis, induced by compounds such as the iron chelator bathophenantroline 14
iron homeostasis responses associated with iron homeostasis, induced by several iron chelators 35
Screen IDConditionsConcentrationPubchem CID
SGTC_11103-hydroxy-3'-methoxyflavone1.24 µM676296
SGTC_13301469-005461.8 µM7102664
SGTC_14224031-002415.5 µM782427
SGTC_1513013-01442.29 µM906558
SGTC_1571348-169565.82 µM5380510
SGTC_162k030-001537.8 µM1809920
SGTC_1658st01294420 µM24207260
SGTC_1660st01296028.1 µM24207266
SGTC_1780st03844824.54 µM728868
SGTC_1787fluconazole80 µM3365
SGTC_20464110841106 µM44119630
SGTC_21535569715200 µM2054701
SGTC_22757947463200 µM1225414
SGTC_22917917025104.35 µM2964612
SGTC_23899091542195.52 µM3626624
SGTC_2398522821348.84 µM80771
SGTC_2586curcumin80 µM6610332
SGTC_263alizarin107.93 µM6293
SGTC_2666tannic acid100 µM16134267
SGTC_2675theaflavin digallate100 µM467320
SGTC_2777climbazole1.54 µM37907
SGTC_2784756767372.73 µM3471247
SGTC_2867903909871.43 µM6463460
SGTC_3141909460949.47 µM25236309
SGTC_3142908649849.47 µM25236367
SGTC_3161910038849.47 µM25236368
SGTC_3175910651749.47 µM41468073
SGTC_3181910827749.47 µM17097298
SGTC_3188911078949.47 µM849217
SGTC_3393091-483371.4 µM3240077
SGTC_3740880-023182.3 µM6833587
SGTC_431k089-0097107 µM5499420
SGTC_444curcumin90.4 µM6610332
SGTC_6990375-0592111 µM762578
SGTC_8480368-008985.6 µM762535

mitochondrial processes responses associated with mitochondrial processes including ATPase inhibition 53
mitochondrial response to ROS responses associated with mitochondrial genome maintenance, induced by compounds such as the antioxidant mangostin, which may participate in redox cycling 16
mitochondrial stress disruption of mitochondrial processes, associated with charged and reactive compounds 10
NEO1 notable drug-induced haploinsufficiency of NEO1, an aminophospholipid plasma membrane flippase 21
NEO1-PIK1 drug-induced haploinsufficiency of NEO1 (aminophospholipid plasma membrane flippase) and PIK1 (phosphatidylinositol 4-kinase) 17
PDR1 notable requirement for PDR1, a transcription factor that regulates the pleiotropic drug response; no other signature genes 26
plasma membrane duress piperazine-induced plasma membrane duress 18
redox potentiating protein catabolism via the multivesicular body sorting pathway associated with the generation of superoxide 27
RNA pol III & RNase P/MRP responses associated with RNA polymerase III and other complexes 17
RNA processing & uracil transport strong requirement for FUR4, a uracil transporter, and RNA processing genes GLC7 and RRP45; no other signature genes 29
RPP1 & pyrimidine depletion notable drug-induced haploinsufficiency of RPP1, a member of RNase P and MRP, complexes that cleave rRNA and tRNA precursors, respectively 85
RSC & ERG11 RSC chromatin structure remodeling complex and ERG11, an ergosterol biosynthesis enzyme 16
RSC complex & mRNA processing RSC chromatin structure remodeling complex and mRNA processing 24
sphingolipid biosynthesis & PDR1 responses associated with sphingolipid biosynthesis and PDR1, a transcription factor that regulates the pleiotropic drug response (induced by surfactants) 14
superoxide pentose phosphate pathway/NADP metabolism 13
SWF1 & branched chain AA biosynthesis branched chain amino acid biosynthesis and protein modification via SWF1 9
translation cytoplasmic and mitochondrial translation 6
TRP & mitochondrial translation thiazolidinone targeting of protein prenylation (RER2) dirupts mitochondrial function 14
TSC3-RPN4 responses associated with a strong requirement for TSC3 (activator of sphingolipid biosynthesis) and a moderate requirement for RPN4 (transcription factor that stimulates expression of proteasome genes) 59
tubulin folding & SWR complex tubulin biogenesis, induced by tubulin inhibitors benomyl and nocodazole 26
ubiquinone biosynthesis & proteasome responses associated with the 20S proteosome, ubiquinone biosynthesis and an adamantyl structure moiety 18
unfolded protein response unfolded protein response induced by inhibition of diverse HIP targets 11