Major Responses

The major response signatures can be explored in detail in the network of response signatures (i.e. a web version of fig. 2).
GO TO network of response signatures

Major response signatures and their associated screens are indicated below (click on arrow to view screens).


Response SignatureDescriptionNumber
of
Screens
60S ribosome export LSG1-NMD3 mediated ribosomal export from the nucleus 102
amide catabolism responses associated with DAL81, a nitrogen catabolite activator 32
Screen IDConditionsConcentrationPubchem CID
SGTC_10563448-1962115 µM715507
SGTC_11871391-0724117 µM6997986
SGTC_1759st04305970 µM669426
SGTC_1819st05344858.6 µM2857616
SGTC_1853st05671091.2 µM269167
SGTC_1854st05623332.9 µM5393174
SGTC_1864st05764530.4 µM688666
SGTC_24605552655174.22 µM5401989
SGTC_253dyclonine31.25 µM3180
SGTC_2680butyl paraben22.24 µM7184
SGTC_2833900131545.46 µM2989378
SGTC_2841900476138.96 µM2991039
SGTC_2845900302442.97 µM2990173
SGTC_2940906063845.86 µM4027022
SGTC_2999906976571.43 µM2097066
SGTC_3088911757849.47 µM678341
SGTC_3225913081949.47 µM4547121
SGTC_3228913179949.47 µM17015818
SGTC_3252810-4341181 µM774970
SGTC_3333486-013140.1 µM6744690
SGTC_3330914142471.43 µM27261020
SGTC_3371315-0038354 µM1626437
SGTC_413propylparaben100 µM7175
SGTC_468gf-109203x121 µM2396
SGTC_486niguldipine82 µM1236
SGTC_563tetrahydrosecaminediol614 µM334274
SGTC_5694130-2812160 µM743552
SGTC_7003453-2283142 µM565664
SGTC_7021488-019094 µM949357
SGTC_7441594-0068283 µM668392
SGTC_7491000-0129128 µM708470
SGTC_9903985-001141.3 µM5399565

anthracycline transcription coupled DNA repair responses associated with SSL2, a member of RNA polymerase transcription factor TFIIH holoenzyme, and DNA damage 7
azole & statin sterol biosynthesis, induced by ergosterol pathway inhibitors such as azoles and statins 26
calcium & mitochondrial duress calcium stress response, includes IMP2', a transcriptional activator involved in ion homeostasis 38
cell wall regulation of cell wall organization 31
cell wall signaling protein kinase C signaling 25
copper-dependent oxidative stress copper transport induced by oxidative stress and copper-dependent SOD1, SOD2 25
DNA damage response DNA damage and repair 34
DNA intercalators responses associated with ERG12 (ergosterol biosynthesis), YMR166C (potential mitochondrial carrier), EFM1 (lysine methyltransferase of eIF1A) and CEP3 (kineticore protein) 27
endomembrane recycling responses associated with RCY1, a protein involved in recycling plasma membrane proteins, and (amino)phospholipid transport 31
ERAD & cell cycle endoplasmic reticulum-associated degradation and cell cycle 11
ERG2 responses associated with ERG2, involved in ergosterol biosynthesis; deletion increases membrane permeability; no other signature genes 49
ergosterol biosynthesis ergosterol biosynthesis 20
ergosterol depletion effects on membrane effects of high concentrations of ergosterol inhibitors on plasma membrane (e.g. vesicular trafficking, sterol biosynthesis) and regulation of GTPase activity 15
excess fatty acid response to excess fatty acid, primarily through LRO1, an acyltransferase that catalyzes diacylglycerol esterification 9
exosome exosome complex; induced by uracil analogs such as 5-fluorouracil 7
fatty acid desaturase (OLE1) responses associated with drug-induced happloinsufficiency of OLE1 (fatty acid desaturase) 36
Golgi intra-Golgi transport involving the COG1-8 Golgi transport complex 71
heat shock/prefoldin responses associated with the prefoldin complex, induced by heat shock 5
heme biosynthesis & mitochondrial translocase heme biosynthesis and the mitchondrial outer membrane translocase complex 19
heme requiring responses associated with heme biosynthesis, induced by compounds such as the iron chelator bathophenantroline 14
iron homeostasis responses associated with iron homeostasis, induced by several iron chelators 35
mitochondrial processes responses associated with mitochondrial processes including ATPase inhibition 53
mitochondrial response to ROS responses associated with mitochondrial genome maintenance, induced by compounds such as the antioxidant mangostin, which may participate in redox cycling 16
mitochondrial stress disruption of mitochondrial processes, associated with charged and reactive compounds 10
NEO1 notable drug-induced haploinsufficiency of NEO1, an aminophospholipid plasma membrane flippase 21
NEO1-PIK1 drug-induced haploinsufficiency of NEO1 (aminophospholipid plasma membrane flippase) and PIK1 (phosphatidylinositol 4-kinase) 17
PDR1 notable requirement for PDR1, a transcription factor that regulates the pleiotropic drug response; no other signature genes 26
plasma membrane duress piperazine-induced plasma membrane duress 18
redox potentiating protein catabolism via the multivesicular body sorting pathway associated with the generation of superoxide 27
RNA pol III & RNase P/MRP responses associated with RNA polymerase III and other complexes 17
RNA processing & uracil transport strong requirement for FUR4, a uracil transporter, and RNA processing genes GLC7 and RRP45; no other signature genes 29
RPP1 & pyrimidine depletion notable drug-induced haploinsufficiency of RPP1, a member of RNase P and MRP, complexes that cleave rRNA and tRNA precursors, respectively 85
RSC & ERG11 RSC chromatin structure remodeling complex and ERG11, an ergosterol biosynthesis enzyme 16
RSC complex & mRNA processing RSC chromatin structure remodeling complex and mRNA processing 24
sphingolipid biosynthesis & PDR1 responses associated with sphingolipid biosynthesis and PDR1, a transcription factor that regulates the pleiotropic drug response (induced by surfactants) 14
superoxide pentose phosphate pathway/NADP metabolism 13
SWF1 & branched chain AA biosynthesis branched chain amino acid biosynthesis and protein modification via SWF1 9
translation cytoplasmic and mitochondrial translation 6
TRP & mitochondrial translation thiazolidinone targeting of protein prenylation (RER2) dirupts mitochondrial function 14
TSC3-RPN4 responses associated with a strong requirement for TSC3 (activator of sphingolipid biosynthesis) and a moderate requirement for RPN4 (transcription factor that stimulates expression of proteasome genes) 59
tubulin folding & SWR complex tubulin biogenesis, induced by tubulin inhibitors benomyl and nocodazole 26
ubiquinone biosynthesis & proteasome responses associated with the 20S proteosome, ubiquinone biosynthesis and an adamantyl structure moiety 18
unfolded protein response unfolded protein response induced by inhibition of diverse HIP targets 11