Major Responses

The major response signatures can be explored in detail in the network of response signatures (i.e. a web version of fig. 2).
GO TO network of response signatures

Major response signatures and their associated screens are indicated below (click on arrow to view screens).

Response SignatureDescriptionNumber
60S ribosome export LSG1-NMD3 mediated ribosomal export from the nucleus 102
Screen IDConditionsConcentrationPubchem CID
SGTC_10154130-452582 µM1363237
SGTC_1033k072-010221.3 µM5965931
SGTC_1070indatraline8.81 µM10314472
SGTC_1081sertraline6 µM63009
SGTC_11433454-24085.08 µM
SGTC_12690831-07963.05 µM927758
SGTC_13341486-0610236 µM3742339
SGTC_1350933-000426.35 µM21230617
SGTC_1360097-0015404.48 µM4861337
SGTC_13833049-003220.7 µM712864
SGTC_13933470-564958.2 µM4108395
SGTC_14043909-782048.3 µM23741373
SGTC_14053909-789412 µM7104060
SGTC_14063909-790611.9 µM
SGTC_14073909-790912.3 µM4411780
SGTC_14264048-448071.7 µM14224343
SGTC_14764112-32943.34 µM704369
SGTC_14924158-055828.5 µM3967268
SGTC_1523st01284444.7 µM4274103
SGTC_15924',5'-dihydroxyflavone8.85 µM688669
SGTC_1605st00008249.1 µM1114022
SGTC_1606st00009449.2 µM1242210
SGTC_1619st00332688.7 µM2849032
SGTC_1663st01414055.4 µM4207120
SGTC_1664st0142179.02 µM3982782
SGTC_1675st01848524.5 µM3323024
SGTC_1676st01848923.4 µM3696235
SGTC_1678st01926580.2 µM5367020
SGTC_1721st0821529.27 µM5296051
SGTC_1733st03735754.9 µM1272339
SGTC_1775st08158835.17 µM1426443
SGTC_1786berberine21.6 µM12456
SGTC_1807st05009258.9 µM5008496
SGTC_1827berberine7.24 µM629413
SGTC_1829berberine14.4 µM2353
SGTC_1833914-005130.55 µM1596232
SGTC_1855st05619539.6 µM4028379
SGTC_1886st05735649.9 µM24207747
SGTC_1913914-012366.51 µM3144412
SGTC_1940st07599051.1 µM1084979
SGTC_1945st07599156.6 µM1084980
SGTC_1958st07651341.9 µM732122
SGTC_1971st06942963.5 µM1246522
SGTC_1983454-287316.19 µM710957
SGTC_20375169046200 µM5718022
SGTC_20785212016200 µM1899708
SGTC_21005377183190 µM2844202
SGTC_2131toluylene red5.29 µM11105
SGTC_21605660466132.93 µM2859134
SGTC_21956536160144.24 µM3834386
SGTC_22047233102200 µM2172480
SGTC_22067254556146.97 µM4398905
SGTC_23307979373200 µM1863007
SGTC_23829035899200 µM6462679
SGTC_2511berberine10.47 µM12456
SGTC_25903,4',5',6',7'-pentamethoxyflavone100 µM521171
SGTC_2716st08085838.62 µM5296050
SGTC_2744captopril92.04 µM44093
SGTC_2803448-36073.04 µM626179
SGTC_2809796413312.99 µM1253665
SGTC_2913796655636.57 µM2976516
SGTC_2937904475311.33 µM6465530
SGTC_2970986-003224 µM2847425
SGTC_2983902267112.99 µM6405161
SGTC_3032908942749.47 µM17173707
SGTC_3034909042149.47 µM17173761
SGTC_3069911700949.47 µM41904981
SGTC_3073911497249.47 µM41905075
SGTC_3093911734449.47 µM24824913
SGTC_3168910341949.47 µM16649256
SGTC_3170910305449.47 µM16432970
SGTC_3185910826749.47 µM4910486
SGTC_3222912830149.47 µM4911358
SGTC_3249913518349.47 µM4902779
SGTC_3251913504749.47 µM17682963
SGTC_3253913598749.47 µM4182430
SGTC_3260913710949.47 µM17478346
SGTC_3269913782349.47 µM17682936
SGTC_3276913906049.47 µM4870619
SGTC_3280914096149.47 µM4901226
SGTC_3287911717337.06 µM2789709
SGTC_344k064-00356.43 µM5088750
SGTC_348k064-001210.7 µM5066323
SGTC_3590081-005815.9 µM3494159
SGTC_403arphamenine a50 µM5487158
SGTC_490717-096532.13 µM5889349
SGTC_5221273-001011.6 µM5705015
SGTC_5700987-006562.6 µM3104428
SGTC_5794491-1009110 µM1271041
SGTC_618k072-023233.2 µM5872756
SGTC_620180-04233.23 µM30102
SGTC_631k072-023041.5 µM5773147
SGTC_6450845-09435.41 µM1885106
SGTC_6851278-003354.9 µM3590572
SGTC_6861319-0111510 µM4562600
SGTC_7651319-0117244 µM3487746
SGTC_8103825-7150143 µM22330411
SGTC_850868-0259160.06 µM83173
SGTC_8660495-0101262 µM635694
SGTC_9531188-00459.7 µM6144426
SGTC_970535-070119.13 µM2832013
SGTC_9761348-106747.6 µM5310671

amide catabolism responses associated with DAL81, a nitrogen catabolite activator 32
anthracycline transcription coupled DNA repair responses associated with SSL2, a member of RNA polymerase transcription factor TFIIH holoenzyme, and DNA damage 7
azole & statin sterol biosynthesis, induced by ergosterol pathway inhibitors such as azoles and statins 26
calcium & mitochondrial duress calcium stress response, includes IMP2', a transcriptional activator involved in ion homeostasis 38
cell wall regulation of cell wall organization 31
cell wall signaling protein kinase C signaling 25
copper-dependent oxidative stress copper transport induced by oxidative stress and copper-dependent SOD1, SOD2 25
DNA damage response DNA damage and repair 34
DNA intercalators responses associated with ERG12 (ergosterol biosynthesis), YMR166C (potential mitochondrial carrier), EFM1 (lysine methyltransferase of eIF1A) and CEP3 (kineticore protein) 27
endomembrane recycling responses associated with RCY1, a protein involved in recycling plasma membrane proteins, and (amino)phospholipid transport 31
ERAD & cell cycle endoplasmic reticulum-associated degradation and cell cycle 11
ERG2 responses associated with ERG2, involved in ergosterol biosynthesis; deletion increases membrane permeability; no other signature genes 49
ergosterol biosynthesis ergosterol biosynthesis 20
ergosterol depletion effects on membrane effects of high concentrations of ergosterol inhibitors on plasma membrane (e.g. vesicular trafficking, sterol biosynthesis) and regulation of GTPase activity 15
excess fatty acid response to excess fatty acid, primarily through LRO1, an acyltransferase that catalyzes diacylglycerol esterification 9
exosome exosome complex; induced by uracil analogs such as 5-fluorouracil 7
fatty acid desaturase (OLE1) responses associated with drug-induced happloinsufficiency of OLE1 (fatty acid desaturase) 36
Golgi intra-Golgi transport involving the COG1-8 Golgi transport complex 71
heat shock/prefoldin responses associated with the prefoldin complex, induced by heat shock 5
heme biosynthesis & mitochondrial translocase heme biosynthesis and the mitchondrial outer membrane translocase complex 19
heme requiring responses associated with heme biosynthesis, induced by compounds such as the iron chelator bathophenantroline 14
iron homeostasis responses associated with iron homeostasis, induced by several iron chelators 35
mitochondrial processes responses associated with mitochondrial processes including ATPase inhibition 53
mitochondrial response to ROS responses associated with mitochondrial genome maintenance, induced by compounds such as the antioxidant mangostin, which may participate in redox cycling 16
mitochondrial stress disruption of mitochondrial processes, associated with charged and reactive compounds 10
NEO1 notable drug-induced haploinsufficiency of NEO1, an aminophospholipid plasma membrane flippase 21
NEO1-PIK1 drug-induced haploinsufficiency of NEO1 (aminophospholipid plasma membrane flippase) and PIK1 (phosphatidylinositol 4-kinase) 17
PDR1 notable requirement for PDR1, a transcription factor that regulates the pleiotropic drug response; no other signature genes 26
plasma membrane duress piperazine-induced plasma membrane duress 18
redox potentiating protein catabolism via the multivesicular body sorting pathway associated with the generation of superoxide 27
RNA pol III & RNase P/MRP responses associated with RNA polymerase III and other complexes 17
RNA processing & uracil transport strong requirement for FUR4, a uracil transporter, and RNA processing genes GLC7 and RRP45; no other signature genes 29
RPP1 & pyrimidine depletion notable drug-induced haploinsufficiency of RPP1, a member of RNase P and MRP, complexes that cleave rRNA and tRNA precursors, respectively 85
RSC & ERG11 RSC chromatin structure remodeling complex and ERG11, an ergosterol biosynthesis enzyme 16
RSC complex & mRNA processing RSC chromatin structure remodeling complex and mRNA processing 24
sphingolipid biosynthesis & PDR1 responses associated with sphingolipid biosynthesis and PDR1, a transcription factor that regulates the pleiotropic drug response (induced by surfactants) 14
superoxide pentose phosphate pathway/NADP metabolism 13
SWF1 & branched chain AA biosynthesis branched chain amino acid biosynthesis and protein modification via SWF1 9
translation cytoplasmic and mitochondrial translation 6
TRP & mitochondrial translation thiazolidinone targeting of protein prenylation (RER2) dirupts mitochondrial function 14
TSC3-RPN4 responses associated with a strong requirement for TSC3 (activator of sphingolipid biosynthesis) and a moderate requirement for RPN4 (transcription factor that stimulates expression of proteasome genes) 59
tubulin folding & SWR complex tubulin biogenesis, induced by tubulin inhibitors benomyl and nocodazole 26
ubiquinone biosynthesis & proteasome responses associated with the 20S proteosome, ubiquinone biosynthesis and an adamantyl structure moiety 18
unfolded protein response unfolded protein response induced by inhibition of diverse HIP targets 11