HIPHOP chemogenomics database

Major Responses

The major response signatures can be explored in detail in the network of response signatures (i.e. a web version of fig. 2).
GO TO network of response signatures

Major response signatures and their associated screens are indicated below (click on arrow to view screens).

	Response Signature	Description	Number of Screens
▶	60S ribosome export	LSG1-NMD3 mediated ribosomal export from the nucleus	102
	Screen ID Conditions Concentration Pubchem CID SGTC_1015 4130-4525 82 µM 1363237 SGTC_1033 k072-0102 21.3 µM 5965931 SGTC_1070 indatraline 8.81 µM 10314472 SGTC_1081 sertraline 6 µM 63009 SGTC_1143 3454-2408 5.08 µM SGTC_1269 0831-0796 3.05 µM 927758 SGTC_1334 1486-0610 236 µM 3742339 SGTC_135 0933-0004 26.35 µM 21230617 SGTC_136 0097-0015 404.48 µM 4861337 SGTC_1383 3049-0032 20.7 µM 712864 SGTC_1393 3470-5649 58.2 µM 4108395 SGTC_1404 3909-7820 48.3 µM 23741373 SGTC_1405 3909-7894 12 µM 7104060 SGTC_1406 3909-7906 11.9 µM SGTC_1407 3909-7909 12.3 µM 4411780 SGTC_1426 4048-4480 71.7 µM 14224343 SGTC_1476 4112-3294 3.34 µM 704369 SGTC_1492 4158-0558 28.5 µM 3967268 SGTC_1523 st012844 44.7 µM 4274103 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 688669 SGTC_1605 st000082 49.1 µM 1114022 SGTC_1606 st000094 49.2 µM 1242210 SGTC_1619 st003326 88.7 µM 2849032 SGTC_1663 st014140 55.4 µM 4207120 SGTC_1664 st014217 9.02 µM 3982782 SGTC_1675 st018485 24.5 µM 3323024 SGTC_1676 st018489 23.4 µM 3696235 SGTC_1678 st019265 80.2 µM 5367020 SGTC_1721 st082152 9.27 µM 5296051 SGTC_1733 st037357 54.9 µM 1272339 SGTC_1775 st081588 35.17 µM 1426443 SGTC_1786 berberine 21.6 µM 12456 SGTC_1807 st050092 58.9 µM 5008496 SGTC_1827 berberine 7.24 µM 629413 SGTC_1829 berberine 14.4 µM 2353 SGTC_183 3914-0051 30.55 µM 1596232 SGTC_1855 st056195 39.6 µM 4028379 SGTC_1886 st057356 49.9 µM 24207747 SGTC_191 3914-0123 66.51 µM 3144412 SGTC_1940 st075990 51.1 µM 1084979 SGTC_1945 st075991 56.6 µM 1084980 SGTC_1958 st076513 41.9 µM 732122 SGTC_1971 st069429 63.5 µM 1246522 SGTC_198 3454-2873 16.19 µM 710957 SGTC_2037 5169046 200 µM 5718022 SGTC_2078 5212016 200 µM 1899708 SGTC_2100 5377183 190 µM 2844202 SGTC_2131 toluylene red 5.29 µM 11105 SGTC_2160 5660466 132.93 µM 2859134 SGTC_2195 6536160 144.24 µM 3834386 SGTC_2204 7233102 200 µM 2172480 SGTC_2206 7254556 146.97 µM 4398905 SGTC_2330 7979373 200 µM 1863007 SGTC_2382 9035899 200 µM 6462679 SGTC_2511 berberine 10.47 µM 12456 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 521171 SGTC_2716 st080858 38.62 µM 5296050 SGTC_2744 captopril 92.04 µM 44093 SGTC_280 3448-3607 3.04 µM 626179 SGTC_2809 7964133 12.99 µM 1253665 SGTC_2913 7966556 36.57 µM 2976516 SGTC_2937 9044753 11.33 µM 6465530 SGTC_297 0986-0032 24 µM 2847425 SGTC_2983 9022671 12.99 µM 6405161 SGTC_3032 9089427 49.47 µM 17173707 SGTC_3034 9090421 49.47 µM 17173761 SGTC_3069 9117009 49.47 µM 41904981 SGTC_3073 9114972 49.47 µM 41905075 SGTC_3093 9117344 49.47 µM 24824913 SGTC_3168 9103419 49.47 µM 16649256 SGTC_3170 9103054 49.47 µM 16432970 SGTC_3185 9108267 49.47 µM 4910486 SGTC_3222 9128301 49.47 µM 4911358 SGTC_3249 9135183 49.47 µM 4902779 SGTC_3251 9135047 49.47 µM 17682963 SGTC_3253 9135987 49.47 µM 4182430 SGTC_3260 9137109 49.47 µM 17478346 SGTC_3269 9137823 49.47 µM 17682936 SGTC_3276 9139060 49.47 µM 4870619 SGTC_3280 9140961 49.47 µM 4901226 SGTC_3287 9117173 37.06 µM 2789709 SGTC_344 k064-0035 6.43 µM 5088750 SGTC_348 k064-0012 10.7 µM 5066323 SGTC_359 0081-0058 15.9 µM 3494159 SGTC_403 arphamenine a 50 µM 5487158 SGTC_49 0717-0965 32.13 µM 5889349 SGTC_522 1273-0010 11.6 µM 5705015 SGTC_570 0987-0065 62.6 µM 3104428 SGTC_579 4491-1009 110 µM 1271041 SGTC_618 k072-0232 33.2 µM 5872756 SGTC_62 0180-0423 3.23 µM 30102 SGTC_631 k072-0230 41.5 µM 5773147 SGTC_645 0845-0943 5.41 µM 1885106 SGTC_685 1278-0033 54.9 µM 3590572 SGTC_686 1319-0111 510 µM 4562600 SGTC_765 1319-0117 244 µM 3487746 SGTC_810 3825-7150 143 µM 22330411 SGTC_85 0868-0259 160.06 µM 83173 SGTC_866 0495-0101 262 µM 635694 SGTC_953 1188-0045 9.7 µM 6144426 SGTC_97 0535-0701 19.13 µM 2832013 SGTC_976 1348-1067 47.6 µM 5310671
▶	amide catabolism	responses associated with DAL81, a nitrogen catabolite activator	32
	Screen ID Conditions Concentration Pubchem CID SGTC_1056 3448-1962 115 µM 715507 SGTC_1187 1391-0724 117 µM 6997986 SGTC_1759 st043059 70 µM 669426 SGTC_1819 st053448 58.6 µM 2857616 SGTC_1853 st056710 91.2 µM 269167 SGTC_1854 st056233 32.9 µM 5393174 SGTC_1864 st057645 30.4 µM 688666 SGTC_2460 5552655 174.22 µM 5401989 SGTC_253 dyclonine 31.25 µM 3180 SGTC_2680 butyl paraben 22.24 µM 7184 SGTC_2833 9001315 45.46 µM 2989378 SGTC_2841 9004761 38.96 µM 2991039 SGTC_2845 9003024 42.97 µM 2990173 SGTC_2940 9060638 45.86 µM 4027022 SGTC_2999 9069765 71.43 µM 2097066 SGTC_3088 9117578 49.47 µM 678341 SGTC_3225 9130819 49.47 µM 4547121 SGTC_3228 9131799 49.47 µM 17015818 SGTC_325 2810-4341 181 µM 774970 SGTC_333 3486-0131 40.1 µM 6744690 SGTC_3330 9141424 71.43 µM 27261020 SGTC_337 1315-0038 354 µM 1626437 SGTC_413 propylparaben 100 µM 7175 SGTC_468 gf-109203x 121 µM 2396 SGTC_486 niguldipine 82 µM 1236 SGTC_563 tetrahydrosecaminediol 614 µM 334274 SGTC_569 4130-2812 160 µM 743552 SGTC_700 3453-2283 142 µM 565664 SGTC_702 1488-0190 94 µM 949357 SGTC_744 1594-0068 283 µM 668392 SGTC_749 1000-0129 128 µM 708470 SGTC_990 3985-0011 41.3 µM 5399565
▶	anthracycline transcription coupled DNA repair	responses associated with SSL2, a member of RNA polymerase transcription factor TFIIH holoenzyme, and DNA damage	7
	Screen ID Conditions Concentration Pubchem CID SGTC_1085 doxorubicin 7.67 µM 443939 SGTC_1105 epirubicin 18.1 µM 65348 SGTC_257 daunorubicin 18.5 µM 30323 SGTC_2662 daunorubicin 22.37 µM 30323 SGTC_272 doxorubicin 8.13 µM 31703 SGTC_2746 daunorubicin 9.88 µM 30323 SGTC_2747 doxorubicin 7.63 µM 31703
▶	azole & statin	sterol biosynthesis, induced by ergosterol pathway inhibitors such as azoles and statins	26
	Screen ID Conditions Concentration Pubchem CID SGTC_1067 clotrimazole 1.36 µM 2812 SGTC_1084 voriconazole 435 nM 71616 SGTC_1086 cerivastatin 2.18 µM 23663992 SGTC_1097 itavastatin 7.23 µM 5282451 SGTC_1191 1487-1166 10.6 µM 3955771 SGTC_1310 1188-0297 994 nM 1588352 SGTC_1311 1190-0148 100 µM 1961333 SGTC_1317 1273-0028 910 nM 5917803 SGTC_1788 fluconazole 20 µM 3365 SGTC_227 fluconazole 33.52 µM 3365 SGTC_2647 atorvastatin 60.16 µM 60823 SGTC_2648 atorvastatin 78.68 µM 60823 SGTC_2753 fluvastatin 17.09 µM 446155 SGTC_2765 myclobutanil 7.74 µM 6336 SGTC_279 1273-0055 2.93 µM 2847562 SGTC_2816 7982706 58.44 µM 2981853 SGTC_2925 9010536 32.5 µM 2994177 SGTC_2991 9074669 71.43 µM 17333109 SGTC_327 1273-0057 3.96 µM 3108138 SGTC_346 4513-0042 7.16 µM 2827372 SGTC_363 0455-0021 3.06 µM 4597466 SGTC_383 2324-0395 7.37 µM 3146421 SGTC_526 4469-0568 170 µM 2901964 SGTC_547 1120-0019 610 nM 3676939 SGTC_862 0452-0056 10.2 µM 1575396 SGTC_902 1120-0002 2.07 µM 3280475
▶	calcium & mitochondrial duress	calcium stress response, includes IMP2', a transcriptional activator involved in ion homeostasis	38
	Screen ID Conditions Concentration Pubchem CID SGTC_1057 3448-5381 134 µM 5497911 SGTC_121 0557-0495 61.34 µM 3104427 SGTC_1260 0700-1617 7.75 µM 2853078 SGTC_1377 2944-0135 198 µM 1894137 SGTC_1450 4112-4260 37.6 µM 1633175 SGTC_1597 7-benzyloxygramine 47.5 µM 260807 SGTC_1621 st003705 32.4 µM 24207032 SGTC_1622 st003707 19.4 µM 10140899 SGTC_1623 st003709 20.3 µM 16192618 SGTC_1624 st003710 6.25 µM 24207033 SGTC_1625 st003711 30.1 µM 24207034 SGTC_1627 st003713 25.6 µM 16195070 SGTC_1666 st014829 29 µM 3858230 SGTC_1690 st023502 41.2 µM 24207482 SGTC_1712 st032288 53.4 µM 2883011 SGTC_1812 st052057 4.33 µM 3645418 SGTC_187 1488-2104 32.73 µM 2852859 SGTC_2513 baicalein 25.65 µM 5281605 SGTC_2523 spermine 47.74 µM 1103 SGTC_2688 kanamycin b 96.69 µM 636396 SGTC_298 1391-0729 10 µM 3237558 SGTC_33 0986-0033 35.82 µM 2848082 SGTC_39 0986-0283 58.35 µM 3110600 SGTC_390 dec-rvkr-cmk 16.7 µM 9962075 SGTC_400 oxethazaine 37.5 µM 4621 SGTC_467 ro 31-8220 72.8 µM 5083 SGTC_502 l-744,832 89.3 µM 6610354 SGTC_528 3492-0019 172 µM 2869262 SGTC_582 0987-0078 156 µM 1625765 SGTC_601 0986-0029 62.9 µM 24747981 SGTC_609 0986-0026 86.3 µM 2848610 SGTC_65 0798-0905 34.99 µM 3602145 SGTC_651 3253-0966 34.4 µM 781462 SGTC_658 3253-0951 102 µM 1184878 SGTC_701 4424-0219 185 µM 2911779 SGTC_852 0418-0143 439 µM 5369229 SGTC_96 0929-0093 37.28 µM 6991579 SGTC_994 3910-0338 138 µM 3479481
▶	cell wall	regulation of cell wall organization	31
	Screen ID Conditions Concentration Pubchem CID SGTC_1053 3366-3204 134 µM 3632071 SGTC_138 0850-0259 40.92 µM 6813004 SGTC_2367 9070478 135.38 µM 572802 SGTC_2584 androsterone 48.74 µM 2754130 SGTC_2619 obliquin 87.91 µM 6708593 SGTC_2912 7964298 10.93 µM 2975850 SGTC_304 1310-0298 97 µM 1550234 SGTC_3266 9136860 49.47 µM 4871271 SGTC_3285 9112818 20.87 µM 17017947 SGTC_3311 9131146 2.88 µM 4900406 SGTC_3321 9137793 26.83 µM 4904192 SGTC_3322 9139058 2.11 µM 4908926 SGTC_3331 9141060 1.96 µM 4906567 SGTC_3350 9150499 3.57 µM 4910996 SGTC_3351 9150312 21.6 µM 4904905 SGTC_3356 9151811 4.48 µM 1859254 SGTC_351 caspofungin 25 nM 9963413 SGTC_354 2783-3500 4.88 µM 6740761 SGTC_360 0957-0399 1.01 µM 6752301 SGTC_397 arbidol 50 µM 131410 SGTC_483 fpl-64176 144 µM 3423 SGTC_514 4466-0038 2.65 nM 5722064 SGTC_58 0957-0393 9 µM 6997992 SGTC_586 0957-0265 8.15 µM 6752309 SGTC_666 0272-0154 136 µM 6870312 SGTC_863 0466-0191 129 µM 765160 SGTC_883 0850-0245 24.6 µM 6823229 SGTC_916 4466-0038 42 nM 5722064 SGTC_928 2764-0428 58.7 µM 662578 SGTC_951 1171-0579 82.7 µM 1616050 SGTC_964 1287-0107 19.4 µM 51516812
▶	cell wall signaling	protein kinase C signaling	25
	Screen ID Conditions Concentration Pubchem CID SGTC_1614 st002383 48.6 µM 1947235 SGTC_1874 staurosporine 7.6 µM 46864193 SGTC_2003 4023581 200 µM 16641307 SGTC_2007 4011539 71.82 µM 45595301 SGTC_2009 4012297 12.05 µM 45595307 SGTC_2028 5153890 36.43 µM 2830968 SGTC_2149 5554786 194.83 µM 745063 SGTC_2210 7115885 190.39 µM 2927039 SGTC_2272 7805186 180 µM 2956062 SGTC_2399 5884133 200 µM 722445 SGTC_241 5hr heat shock (37°C) + cantharidin 155.45 µM 2545 SGTC_2489 cantharidin 73.42 µM 2545 SGTC_2776 terbinafine 19.92 µM 5282481 SGTC_2924 9010168 62.78 µM 2993929 SGTC_3092 9117248 49.47 µM 17141857 SGTC_3122 9126309 49.47 µM 17591206 SGTC_369 0957-0393 4.5 µM 6997992 SGTC_408 cantharidin 100 µM 2545 SGTC_422 cantharidin 155 µM 2545 SGTC_500 h-89 112 µM 449241 SGTC_663 1486-0733 13.9 µM 722445 SGTC_721 1187-1332 279 µM 25730 SGTC_825 1988-2224 89.6 µM 1180859 SGTC_905 2-aminofluorene 215 µM 1539 SGTC_971 1315-0384 26.7 µM 6769120
▶	copper-dependent oxidative stress	copper transport induced by oxidative stress and copper-dependent SOD1, SOD2	25
	Screen ID Conditions Concentration Pubchem CID SGTC_100 0086-0128 49.59 µM 93297 SGTC_1000 4048-0884 8.67 µM 13040088 SGTC_1001 4048-4355 44.4 µM 21824233 SGTC_106 0092-0003 11.58 µM 1072148 SGTC_1425 4048-4433 7.33 µM 23734946 SGTC_1763 st044482 94.5 µM 88505 SGTC_2080 5212524 12.4 µM 260183 SGTC_2130 NSC 7 2.45 µM 21448 SGTC_2171 5739187 198.08 µM 2262761 SGTC_2196 6573537 42.67 µM 2903087 SGTC_23 0213-0011 40 µM 627608 SGTC_2507 purpurin 79.67 µM 6683 SGTC_2617 dihydrotanshinone i 20.83 µM 5316743 SGTC_2682 pyrogallin 40.03 µM 822798 SGTC_2810 7959871 45.46 µM 2974535 SGTC_318 1488-0629 67.2 µM 3662576 SGTC_381 3461-2219 42.7 µM 2883159 SGTC_495 decylubiquinone 155 µM 2971 SGTC_612 0302-0167 22.4 µM 235821 SGTC_626 0214-0009 33 µM 3437874 SGTC_670 4204-0025 119 µM 719039 SGTC_725 1497-0963 19 µM 3549977 SGTC_754 3474-0146 171 µM 24762078 SGTC_857 0438-0306 1.35 µM 4686136 SGTC_858 0438-0351 2.77 µM 2799119
▶	DNA damage response	DNA damage and repair	34
	Screen ID Conditions Concentration Pubchem CID SGTC_1079 idarubicin 2.36 µM 636362 SGTC_1082 camptothecin 424.86 nM 2538 SGTC_1168 k815-0004 80.5 µM 642433 SGTC_1185 1319-0113 81.3 µM 4672763 SGTC_1298 1079-1278 263 µM 2840950 SGTC_1525 8-methoxypsoralen 92.5 µM 4114 SGTC_1693 xanthone 101.9 µM 7020 SGTC_1707 st032323 6.32 µM 3132057 SGTC_1936 st074407 74.3 µM 809813 SGTC_244 nsc-207895 1.3 µM 42640 SGTC_247 mechlorethamine 29.71 µM 22133593 SGTC_248 streptozotocin 5.23 mM 5300 SGTC_251 melphalan 456.52 µM 460612 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 364106 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 5955 SGTC_2671 danthron 100 µM 2950 SGTC_2677 mitomycin C 100 µM 5746 SGTC_268 camptothecin 39.62 µM 24360 SGTC_3124 9127567 49.47 µM 17592030 SGTC_3247 9135149 49.47 µM 8934436 SGTC_3254 9136651 49.47 µM 16454030 SGTC_411 enrofloxacin 100 µM 71188 SGTC_419 nsc-638432 893 µM 368090 SGTC_429 1112-0049 25.5 µM 2836170 SGTC_546 peri-Naphthalide 147 µM 223824 SGTC_558 k064-0027 21.3 µM 5088526 SGTC_580 1123-0028 41 µM 1677248 SGTC_698 k064-0052 127 µM 5088751 SGTC_707 0865-0008 204 µM 723043 SGTC_73 0327-0325 16.23 µM 53298 SGTC_824 1304-0008 100 µM 768245 SGTC_829 1635-0120 117 µM 285054 SGTC_915 methyl methanesulfonate (MMS) 110 mM 4156 SGTC_93 0109-0045 59.23 µM 88733
▶	DNA intercalators	responses associated with ERG12 (ergosterol biosynthesis), YMR166C (potential mitochondrial carrier), EFM1 (lysine methyltransferase of eIF1A) and CEP3 (kineticore protein)	27
	Screen ID Conditions Concentration Pubchem CID SGTC_125 0133-0007 11.75 µM 26541 SGTC_126 0417-1624 672.48 µM 41912 SGTC_1290 0986-0249 10.2 µM 53329 SGTC_1415 3966-0071 78.1 µM 2893185 SGTC_144 4161-2749 112.38 µM 797501 SGTC_145 3737-0113 38.37 µM 6849351 SGTC_1459 k035-0031 35.7 µM 3877128 SGTC_1465 k213-0056 144 µM 24048857 SGTC_1468 k284-1086 134 µM 15996457 SGTC_1487 3970-0795 2.82 µM 3765103 SGTC_1515 3460-0031 42.1 µM 2876596 SGTC_1519 esterone 74 µM 698 SGTC_1533 dihydroergotamine mesylate 29.4 µM 71171 SGTC_166 k072-0058 166.42 µM 5846229 SGTC_1926 methyl fluorone black 53.6 µM 72721 SGTC_219 mitoxanthrone 164.41 µM 4212 SGTC_264 promethazine 12.5 mM 6014 SGTC_3040 9091894 49.47 µM 25236966 SGTC_3283 9109332 35.82 µM 17027281 SGTC_370 0180-0345 38.7 µM 3989527 SGTC_412 gemfibrozil 100 µM 3463 SGTC_471 1-acyl-paf 4 µM 16759367 SGTC_511 blebbistatin 171 µM 3476986 SGTC_512 prima-1 270 µM 322968 SGTC_633 0437-0093 97.7 µM 2831118 SGTC_711 k292-0785 179 µM 4146315 SGTC_867 0518-0118 155 µM 6848158
▶	endomembrane recycling	responses associated with RCY1, a protein involved in recycling plasma membrane proteins, and (amino)phospholipid transport	31
	Screen ID Conditions Concentration Pubchem CID SGTC_1102 cgs 12066b 26.1 µM 6438352 SGTC_1199 1638-0010 4.46 µM 3111136 SGTC_1230 0170-0365 3.77 µM 4018932 SGTC_1282 0886-0010 32.4 µM 2836211 SGTC_1394 3474-0001 65.7 µM 5017666 SGTC_15 0266-0086 27.1 µM 1712902 SGTC_156 3474-0145 5.64 µM 2265471 SGTC_1672 st016598 6.51 µM 4665860 SGTC_1750 st081859 2.36 µM 5291695 SGTC_181 1447-1644 8.07 µM 534600 SGTC_197 4544-0043 41.56 µM 896523 SGTC_2006 4011487 200 µM 45595294 SGTC_2021 4019055 173 µM 44827708 SGTC_207 4185-0010 4.49 µM 3761753 SGTC_2228 7354201 200 µM 753451 SGTC_2359 9039622 200 µM 6463596 SGTC_2374 9071832 200 µM 17381698 SGTC_2380 9035439 200 µM 6462575 SGTC_260 nsc-65238 3.99 µM 3246252 SGTC_2694 st077685 81.9 µM 2838096 SGTC_2699 st077704 54.6 µM 645852 SGTC_2790 5423970 71.43 µM 1376240 SGTC_2896 9052656 71.43 µM 6469436 SGTC_3218 9131285 49.47 µM 17156417 SGTC_3320 9137005 35.14 µM 4908713 SGTC_649 1123-0311 367 µM 693629 SGTC_788 1182-0090 188 µM 5715185 SGTC_83 0170-0301 39.03 µM 3089716 SGTC_887 0885-0007 9.62 µM 5719458 SGTC_945 3381-0768 11.3 µM 1126236 SGTC_954 1189-0853 2.85 µM 2828194
▶	ERAD & cell cycle	endoplasmic reticulum-associated degradation and cell cycle	11
	Screen ID Conditions Concentration Pubchem CID SGTC_1026 k007-1105 30.6 µM 7066794 SGTC_103 0844-0104 51.84 µM 5375804 SGTC_1161 k007-0610 110 µM 5843850 SGTC_2322 7413319 38.22 µM 1840400 SGTC_352 k048-0007 5.11 µM 6811911 SGTC_373 0844-0104 25.9 µM 5375804 SGTC_384 k007-0144 5.16 µM 6824886 SGTC_426 0988-0037 14.6 µM 5383008 SGTC_568 1193-0097 7.48 µM 3646150 SGTC_733 4069-0007 56.1 µM 5717425 SGTC_805 3852-0218 479 µM 6615355
▶	ERG2	responses associated with ERG2, involved in ergosterol biosynthesis; deletion increases membrane permeability; no other signature genes	49
	Screen ID Conditions Concentration Pubchem CID SGTC_1206 3978-0017 132 µM 3873677 SGTC_1241 0364-0022 50.8 µM 4563895 SGTC_1244 0416-0015 52.5 µM 96201 SGTC_1245 0418-0076 17.2 µM 6790114 SGTC_1247 0448-0043 5.84 µM 3089013 SGTC_13 0199-0087 65 µM 4589825 SGTC_1339 1486-1321 22.7 µM 3469382 SGTC_1360 1598-0022 39.8 µM 761525 SGTC_1368 1852-0141 284 µM 2838987 SGTC_1448 4255-0083 152 µM 5399660 SGTC_1694 st024011 44.9 µM 2787533 SGTC_1826 st055655 41.6 µM 676168 SGTC_2055 5235184 200 µM 2836034 SGTC_2133 5320837 200 µM 2841355 SGTC_2144 5628481 200 µM 2818399 SGTC_2300 7976697 71.57 µM 2236109 SGTC_234 nsc-17383 10.7 µM 408974 SGTC_2463 5473429 200 µM 5399405 SGTC_2533 agelasine 13.65 µM 16667745 SGTC_2720 fluspirilene 36.88 µM 3396 SGTC_2724 maprotiline 69.64 µM 4011 SGTC_2732 terfenadine 20 µM 5405 SGTC_2734 clemastine 41.6 µM 26987 SGTC_2820 7989630 71.43 µM 2984098 SGTC_2862 9027634 71.43 µM 5012562 SGTC_2951 9072950 58.06 µM 16488155 SGTC_3042 9091578 49.47 µM 25236497 SGTC_3072 9116419 49.47 µM 17170162 SGTC_3127 9126946 49.47 µM 27243249 SGTC_3172 9105863 49.47 µM 2348785 SGTC_3174 9107204 49.47 µM 3938802 SGTC_3177 9107506 49.47 µM 8897194 SGTC_323 4013-0906 34.3 µM 2910086 SGTC_43 0570-0105 72.5 µM 1114046 SGTC_469 w7 172 µM 45115570 SGTC_5 0352-0601 109.88 µM 762456 SGTC_518 1021-0119 62.6 µM 1097762 SGTC_54 0159-0055 9 µM 3319099 SGTC_543 3844-1095 191 µM 4230703 SGTC_562 3772-2733 112 µM 2876874 SGTC_598 3937-0236 20.2 µM 1379313 SGTC_634 1611-4317 11.2 µM 2843522 SGTC_713 1488-1073 324 µM 3312542 SGTC_724 3910-0327 137 µM 2885483 SGTC_742 0kpi-0133 140 µM 2728852 SGTC_776 4476-4378 112 µM 2892008 SGTC_789 1309-1135 70.6 µM 3092424 SGTC_870 0573-2213 57.6 µM 3916321 SGTC_974 1326-0144 138 µM 5411856
▶	ergosterol biosynthesis	ergosterol biosynthesis	20
	Screen ID Conditions Concentration Pubchem CID SGTC_1237 0330-0133 46.1 µM SGTC_147 4466-0538 29.23 µM 6742687 SGTC_1547 harmine 94.2 µM 5280953 SGTC_1638 st008370 60.6 µM 24207134 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 17037758 SGTC_193 1273-0060 1.56 µM 2847393 SGTC_2147 5545932 89.72 µM 797404 SGTC_2155 5570423 76 µM 797402 SGTC_2185 6113692 200 µM 874150 SGTC_2201 6605497 169.86 µM 670741 SGTC_2350 9023895 38.85 µM 2997209 SGTC_2377 9073351 62.6 µM 7337946 SGTC_2525 harmine 47.85 µM 5280953 SGTC_269 exalamide 29 µM 3316 SGTC_2971 9092186 9.93 µM 25236400 SGTC_2974 9094440 9.66 µM 25236134 SGTC_555 4296-0685 37 µM 2908540 SGTC_61 0978-8327 98.57 µM 6150059 SGTC_734 2023-0417 80 µM 3935732 SGTC_917 harmaline 728.09 nM 5280951
▶	ergosterol depletion effects on membrane	effects of high concentrations of ergosterol inhibitors on plasma membrane (e.g. vesicular trafficking, sterol biosynthesis) and regulation of GTPase activity	15
	Screen ID Conditions Concentration Pubchem CID SGTC_1019 4262-0212 3.4 µM 4677213 SGTC_1072 oxiconazole 14.9 nM 47316 SGTC_178 4092-0806 87.51 µM 2169044 SGTC_201 4262-0159 12.8 µM 1341029 SGTC_217 ketoconazole 989 nM 456201 SGTC_2249 haloperidol 116.36 µM 3559 SGTC_252 miconazole 1.31 nM 4189 SGTC_254 nsc-64875 3.81 µM 56993 SGTC_256 clotrimazole 625 nM 2812 SGTC_262 fenpropimorph 62.5 µM 91695 SGTC_2778 tioconazole 65.09 nM 5482 SGTC_312 4092-0653 6.84 µM 1148278 SGTC_320 4092-0846 5.34 µM 1359356 SGTC_57 miconazole 162.5 nM 4189 SGTC_689 0833-0039 98 µM 5374726
▶	excess fatty acid	response to excess fatty acid, primarily through LRO1, an acyltransferase that catalyzes diacylglycerol esterification	9
	Screen ID Conditions Concentration Pubchem CID SGTC_1255 0566-0045 221 µM 2788469 SGTC_1511 0906-3109 28.5 µM 2882180 SGTC_2541 muurolladie-3-one 83.07 µM 3989419 SGTC_410 α-linolenic acid 100 µM 860 SGTC_45 0kpi-0036 14.9 µM 2795021 SGTC_475 α-linolenic acid 10 µM 5280934 SGTC_743 1275-0778 158 µM 2849257 SGTC_795 0685-0265 78 µM 302754 SGTC_922 1866-0035 480 µM 3156169
▶	exosome	exosome complex; induced by uracil analogs such as 5-fluorouracil	7
	Screen ID Conditions Concentration Pubchem CID SGTC_1074 carmofur 3.8 µM 2577 SGTC_1077 5-fluorocytosine 377 nM 3366 SGTC_1698 5-fluorocytosine 1.06 µM 3366 SGTC_261 5-fluorouridine 15.38 µM 1821 SGTC_423 5-fluorouracil 457 µM 3385 SGTC_610 4215-0184 155 µM 5605015 SGTC_617 3770-0098 35 µM 5962639
▶	fatty acid desaturase (OLE1)	responses associated with drug-induced happloinsufficiency of OLE1 (fatty acid desaturase)	36
	Screen ID Conditions Concentration Pubchem CID SGTC_1281 0884-0031 11.8 µM 1548255 SGTC_1308 1187-1617 41.4 µM 2882570 SGTC_1356 1502-0781 85.8 µM 567702 SGTC_1390 3413-2614 145 µM 3421432 SGTC_2050 5263056 171 µM 763468 SGTC_218 alverine citrate 93.75 µM 21718 SGTC_258 haloperidol 50.78 µM 3559 SGTC_2757 clomiphene 4.22 µM 1548953 SGTC_2792 7535235 81.82 µM 1281891 SGTC_2825 7998094 58.44 µM 2987815 SGTC_2838 9002687 71.43 µM 6457060 SGTC_2880 9042983 58.44 µM 6464714 SGTC_2887 9044784 58.44 µM 6465546 SGTC_2893 9048488 25.97 µM 6467338 SGTC_2938 9059746 27.26 µM 6471769 SGTC_2993 9054257 71.43 µM 6470217 SGTC_3027 9089541 49.47 µM 9943819 SGTC_3033 9090887 49.47 µM 19325384 SGTC_3054 9094397 49.47 µM 2598354 SGTC_3071 9117417 49.47 µM 45595590 SGTC_3081 9117243 49.47 µM 45595589 SGTC_3126 9127922 49.47 µM 45595682 SGTC_3145 9085516 49.47 µM 25236195 SGTC_3335 9143315 29.63 µM 4899691 SGTC_577 r071-0003 38.6 µM 4568517 SGTC_637 1181-0519 7.26 µM 6252091 SGTC_669 0108-0021 26.2 µM 17201 SGTC_688 0527-0193 473 µM 4007154 SGTC_706 4262-0057 46.9 µM 883298 SGTC_710 3448-4187 58 µM 3946412 SGTC_75 0159-0059 199.01 µM 5377270 SGTC_768 0384-0033 77.3 µM 3965305 SGTC_779 1360-0071 233 µM 7566 SGTC_813 k007-0158 173 µM 6523916 SGTC_868 0527-0199 213 µM 2849450 SGTC_875 0709-0210 25.7 µM 6251364
▶	Golgi	intra-Golgi transport involving the COG1-8 Golgi transport complex	71
	Screen ID Conditions Concentration Pubchem CID SGTC_1034 k072-0165 12.7 µM 5835461 SGTC_1035 k081-0041 55.2 µM 731709 SGTC_1039 k821-0043 94 µM 15992768 SGTC_1060 3448-7350 82 µM 570178 SGTC_1078 idebenone 36.1 µM 3686 SGTC_1162 k048-0130 20.1 µM 6797406 SGTC_1176 0848-0131 83.3 µM 6769040 SGTC_1201 1889-3372 45.9 µM 5392199 SGTC_1238 0333-0287 48.8 µM 7226 SGTC_1306 1185-0270 9.02 µM 1548076 SGTC_1325 1431-0015 227 µM 1103340 SGTC_1363 1636-0063 10.4 µM 6072185 SGTC_1373 2887-0003 58.5 µM 776948 SGTC_1408 3909-7976 48.8 µM 24152374 SGTC_1460 k062-0059 9.15 µM 1373085 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 165521 SGTC_1581 himbacine 57.9 µM 5281825 SGTC_1631 benzylvanillin 81.9 µM 75506 SGTC_1667 st014849 34.6 µM 5348460 SGTC_1669 st015249 58.4 µM 722793 SGTC_1679 4130-1276 6.7 µM 1005053 SGTC_1735 st034310 56.75 µM 871153 SGTC_1751 st044839 27.19 µM 5291326 SGTC_1783 st039459 87.52 µM 729761 SGTC_1917 st066507 28.5 µM 3156428 SGTC_2030 5175110 200 µM 2831986 SGTC_2182 6325192 200 µM 736248 SGTC_2242 6630449 61.27 µM 691249 SGTC_2346 9031566 143.75 µM 4771086 SGTC_2363 9053361 176 µM 6469797 SGTC_2495 cafestol 54.53 µM 16667697 SGTC_2543 pimpinellin 60.67 µM 4825 SGTC_2737 bleomycin 30.5 nM 16211318 SGTC_281 1672-3440 14.9 µM 6833000 SGTC_2890 9046729 58.44 µM 903329 SGTC_2900 5328528 85.29 µM 795359 SGTC_2902 5787006 60.46 µM 591003 SGTC_291 4130-1278 35.5 µM 1068044 SGTC_2923 7992654 58.14 µM 2985126 SGTC_3053 9095903 49.47 µM 17174018 SGTC_3057 9095946 49.47 µM 24540043 SGTC_306 1672-3436 11.6 µM 6797378 SGTC_3098 9119039 49.47 µM 17161528 SGTC_3149 9097855 49.47 µM 25236625 SGTC_3166 9102297 49.47 µM 25237072 SGTC_3187 9109394 49.47 µM 17098090 SGTC_3219 9131112 49.47 µM 17612988 SGTC_3277 9138724 49.47 µM 15943418 SGTC_3310 9130229 44.14 µM 7761258 SGTC_3325 9138760 55.18 µM 43844959 SGTC_3338 9144300 39.57 µM 4901274 SGTC_366 0181-0206 4.31 µM 274874 SGTC_4 0960-0234 25.67 µM 6821112 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 2374 SGTC_538 2922-0838 53.3 µM 777039 SGTC_557 1315-0110 16.2 µM 6833801 SGTC_56 0957-0365 83.25 µM 6752360 SGTC_605 1315-0399 119 µM 24020461 SGTC_624 k048-0052 28 µM 6835531 SGTC_632 0781-2353 4.65 µM 6811515 SGTC_679 0422-0091 41.4 µM 627384 SGTC_684 1140-0066 328 µM 6813534 SGTC_71 0417-1750 47.81 µM 6811472 SGTC_717 1532-0246 73.2 µM 9561992 SGTC_736 0958-0254 92.6 µM 6812352 SGTC_757 1066-0008 322 µM 6842497 SGTC_777 1315-0167 517 µM 4221767 SGTC_855 0428-0020 25 µM 6812414 SGTC_91 0417-1751 58.38 µM 6795624 SGTC_98 0074-0023 107.66 µM 3563821 SGTC_999 4022-0066 22.7 µM 740511
▶	heat shock/prefoldin	responses associated with the prefoldin complex, induced by heat shock	5
	Screen ID Conditions Concentration Pubchem CID SGTC_238 5hr heat shock (37°C) + nsc-638432 8.93 µM 368090 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.44 µM 5746 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 91467 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.57 µM 3385 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 5269
▶	heme biosynthesis & mitochondrial translocase	heme biosynthesis and the mitchondrial outer membrane translocase complex	19
	Screen ID Conditions Concentration Pubchem CID SGTC_1 0258-0098 57.37 µM 6790032 SGTC_1044 1222-0021 1.78 µM 4306703 SGTC_1098 clofazimine 15.1 µM 2794 SGTC_1113 artemisinin 1.18 µM 2240 SGTC_1453 4237-0541 195 µM 739892 SGTC_1831 st055328 12 µM 1103068 SGTC_2066 5222451 176 µM 2281147 SGTC_208 k072-0098 12.37 µM 5948901 SGTC_2124 5246320 200 µM 579342 SGTC_2129 girgensonine 121.05 µM 442638 SGTC_2336 9001819 198.65 µM 2989602 SGTC_2519 cryptotanshinone 88.04 µM 160254 SGTC_26 0302-0163 425.16 µM 3100915 SGTC_273 hydroxyurea 18.1 mM 3657 SGTC_2928 9011484 9.79 µM 2994751 SGTC_2930 9013230 14.89 µM 2995857 SGTC_553 k007-0256 45.7 µM 6287000 SGTC_623 k072-0108 16.9 µM 5382803 SGTC_842 0271-0008 11.1 µM 1221709
▶	heme requiring	responses associated with heme biosynthesis, induced by compounds such as the iron chelator bathophenantroline	14
	Screen ID Conditions Concentration Pubchem CID SGTC_1301 naphtanilide LB 4.81 µM 67238 SGTC_171 k064-0041 9.68 µM 53325 SGTC_1785 bathophenanthroline 24 µM 72812 SGTC_2179 6298986 200 µM 738374 SGTC_2645 abamectin 100 µM 5702208 SGTC_2739 tacrine 100.86 µM 1935 SGTC_2766 oltipraz 83.91 µM 47318 SGTC_284 0988-0104 32.6 µM 4666532 SGTC_350 k064-0020 19.8 µM 2790705 SGTC_490 phenamil 164 µM 4755 SGTC_584 0986-0246 15.4 µM 53315 SGTC_607 4491-0986 66.8 µM 698981 SGTC_674 0498-0004 451 µM 4231473 SGTC_966 1300-0360 30.2 µM 70588
▶	iron homeostasis	responses associated with iron homeostasis, induced by several iron chelators	35
	Screen ID Conditions Concentration Pubchem CID SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24 µM 676296 SGTC_1330 1469-0054 61.8 µM 7102664 SGTC_1422 4031-0024 15.5 µM 782427 SGTC_151 3013-0144 2.29 µM 906558 SGTC_157 1348-1695 65.82 µM 5380510 SGTC_162 k030-0015 37.8 µM 1809920 SGTC_1658 st012944 20 µM 24207260 SGTC_1660 st012960 28.1 µM 24207266 SGTC_1780 st038448 24.54 µM 728868 SGTC_1787 fluconazole 80 µM 3365 SGTC_2046 4110841 106 µM 44119630 SGTC_2153 5569715 200 µM 2054701 SGTC_2275 7947463 200 µM 1225414 SGTC_2291 7917025 104.35 µM 2964612 SGTC_2389 9091542 195.52 µM 3626624 SGTC_2398 5228213 48.84 µM 80771 SGTC_2586 curcumin 80 µM 6610332 SGTC_263 alizarin 107.93 µM 6293 SGTC_2666 tannic acid 100 µM 16134267 SGTC_2675 theaflavin digallate 100 µM 467320 SGTC_2777 climbazole 1.54 µM 37907 SGTC_2784 7567673 72.73 µM 3471247 SGTC_2867 9039098 71.43 µM 6463460 SGTC_3141 9094609 49.47 µM 25236309 SGTC_3142 9086498 49.47 µM 25236367 SGTC_3161 9100388 49.47 µM 25236368 SGTC_3175 9106517 49.47 µM 41468073 SGTC_3181 9108277 49.47 µM 17097298 SGTC_3188 9110789 49.47 µM 849217 SGTC_339 3091-4833 71.4 µM 3240077 SGTC_374 0880-0231 82.3 µM 6833587 SGTC_431 k089-0097 107 µM 5499420 SGTC_444 curcumin 90.4 µM 6610332 SGTC_699 0375-0592 111 µM 762578 SGTC_848 0368-0089 85.6 µM 762535
▶	mitochondrial processes	responses associated with mitochondrial processes including ATPase inhibition	53
	Screen ID Conditions Concentration Pubchem CID SGTC_1145 3546-0597 10.2 µM 875334 SGTC_120 rhodamine 6G 52.26 µM 65211 SGTC_1371 2421-0008 32.7 µM 2827552 SGTC_1387 3342-1166 1.8 µM 3418228 SGTC_1396 3511-0007 98.6 µM SGTC_1567 st069303 68.4 µM 5581319 SGTC_1583 clindamycin 39.6 µM 32603 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 94937 SGTC_1591 genipin 88.4 µM 442424 SGTC_1641 st009299 47.1 µM 4046054 SGTC_1644 st010134 20.9 µM 3818134 SGTC_1686 st019653 115.5 µM 97252 SGTC_1722 st034304 3.65 µM 4036148 SGTC_1723 st034307 2.55 µM 867466 SGTC_1897 st060201 15 µM 611878 SGTC_1992 st073643 23.3 µM 3161292 SGTC_2001 4023502 57.66 µM 108941 SGTC_2002 4023503 131 µM 4736863 SGTC_2011 4012611 177 µM 2049887 SGTC_2176 5809774 33.97 µM 2870539 SGTC_2183 6420625 130.51 µM 2897619 SGTC_2188 6126565 140.68 µM 874518 SGTC_2199 6590217 200 µM 703109 SGTC_2256 7954252 200 µM 2972920 SGTC_2284 7945075 39.21 µM 1245402 SGTC_2326 6164455 177.58 µM 2888790 SGTC_2348 9022543 33.42 µM 3162678 SGTC_2370 9071495 200 µM 21791103 SGTC_2375 9072683 200 µM 16798029 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 14077415 SGTC_2418 pentamidine 31.67 µM 4735 SGTC_2459 5811157 9.22 µM 2870684 SGTC_2471 5466956 24.79 µM 724419 SGTC_2475 5812728 15.03 µM 776160 SGTC_2630 antimycin a 100 µM 5702199 SGTC_2640 pentamidine 10.38 µM 4735 SGTC_2676 harmalol 100 µM 5459187 SGTC_2718 lomofungin 53.02 µM 5351222 SGTC_2727 riluzole 51.77 µM 5070 SGTC_3192 9110362 49.47 µM 16649480 SGTC_3196 9111891 49.47 µM 18891510 SGTC_3198 9112019 49.47 µM 45595555 SGTC_493 zm226600 134 µM 5240098 SGTC_509 pifithrin 175 µM 4817 SGTC_529 4076-0302 30.3 µM 5816522 SGTC_534 k292-0788 63.4 µM 4146317 SGTC_69 0096-0274 206.68 µM 6741392 SGTC_730 1436-0052 41.2 µM 768764 SGTC_745 0469-0705 296 µM 3486736 SGTC_851 0394-0702 453 µM 762646 SGTC_880 0833-0487 87.2 µM 76075 SGTC_911 3456-4043 236 µM 914281 SGTC_969 1313-0238 134 µM 5212874
▶	mitochondrial response to ROS	responses associated with mitochondrial genome maintenance, induced by compounds such as the antioxidant mangostin, which may participate in redox cycling	16
	Screen ID Conditions Concentration Pubchem CID SGTC_1036 k216-0215 33.5 µM 622330 SGTC_1123 mangostin 811.29 nM 5281650 SGTC_116 0155-0182 31.79 µM 771486 SGTC_1240 0356-0016 42.1 µM 4305613 SGTC_127 0180-0333 59.13 µM 771601 SGTC_1347 1493-0251 600 nM 3986378 SGTC_1353 1498-1206 8.11 µM 6756808 SGTC_141 0443-0274 32.33 µM 1627241 SGTC_1998 st075797 76.8 µM 24208315 SGTC_2054 5233173 129 µM 6889 SGTC_2911 7942208 15.64 µM 1243384 SGTC_2965 9082772 38.63 µM 16459634 SGTC_3062 9077494 49.47 µM 16459633 SGTC_365 0121-0052 13.6 µM 3101739 SGTC_372 0155-0182 15.9 µM 771486 SGTC_778 3456-2434 196 µM 5539063
▶	mitochondrial stress	disruption of mitochondrial processes, associated with charged and reactive compounds	10
	Screen ID Conditions Concentration Pubchem CID SGTC_1188 1403-0014 4.57 µM 9614867 SGTC_119 0121-0043 24.82 µM 1092378 SGTC_124 0136-0217 7.12 µM 3976905 SGTC_173 1273-0061 2.69 µM 2847414 SGTC_1742 st038235 28.89 µM 564103 SGTC_275 trichlorophene 5.69 µM 62616 SGTC_310 1273-0058 1.06 µM 2734232 SGTC_63 0099-0242 26.7 µM 3898502 SGTC_70 0141-0289 43.28 µM 352408 SGTC_908 3448-7491 47.7 µM 1203031
▶	NEO1	notable drug-induced haploinsufficiency of NEO1, an aminophospholipid plasma membrane flippase	21
	Screen ID Conditions Concentration Pubchem CID SGTC_1130 3454-2858 15.9 µM 715628 SGTC_1665 st014639 11.4 µM 981133 SGTC_1680 diphenhydramine 100 µM 8980 SGTC_172 1112-0046 2.64 µM 2802135 SGTC_1781 st038725 66.3 µM 4270275 SGTC_1797 st048695 56.8 µM 592262 SGTC_1991 st073000 8.92 µM 4301969 SGTC_2036 5160441 105 µM 134534 SGTC_206 4546-0025 72.01 µM 6620745 SGTC_232 clozapine 119 µM 2818 SGTC_2658 polymyxin b sulfate 77.05 µM 5702105 SGTC_2697 mebhydrolin 72.4 µM 22530 SGTC_270 tamoxifen 5.46 µM 5376 SGTC_2742 clothiapine 36.27 µM 16351 SGTC_2973 9094665 17.96 µM 25237061 SGTC_301 4119-0100 24.5 µM 2801 SGTC_535 2293-4129 48.2 µM 396118 SGTC_834 0312-0008 75.7 µM 6385573 SGTC_888 0916-0002 6.97 µM 2802138 SGTC_900 1112-0045 141 µM 56211 SGTC_940 3232-1287 54.8 µM 1585493
▶	NEO1-PIK1	drug-induced haploinsufficiency of NEO1 (aminophospholipid plasma membrane flippase) and PIK1 (phosphatidylinositol 4-kinase)	17
	Screen ID Conditions Concentration Pubchem CID SGTC_146 3448-8650 53.13 µM 2891488 SGTC_1754 st042065 16.14 µM 1126236 SGTC_1760 st045453 10.45 µM 3323419 SGTC_1800 st050079 29.07 µM 3645560 SGTC_1801 st050089 28.44 µM 5008493 SGTC_1803 st050068 52.4 µM 3984059 SGTC_1818 st052136 56.3 µM 674169 SGTC_221 trifluoperazine 10.3 µM 5566 SGTC_2257 7960413 200 µM 2974689 SGTC_3037 9091026 49.47 µM 25236398 SGTC_313 3474-0040 5.03 µM 1043375 SGTC_3152 9099253 49.47 µM 25236131 SGTC_439 amiodarone 34.4 µM 2157 SGTC_443 clozapine 122 µM 2818 SGTC_445 e6 berbamine 66 µM 6610268 SGTC_447 ml7 120 µM 4216 SGTC_449 xestospongin c 11.19 µM 5311502
▶	PDR1	notable requirement for PDR1, a transcription factor that regulates the pleiotropic drug response; no other signature genes	26
	Screen ID Conditions Concentration Pubchem CID SGTC_1008 4106-0037 6 µM 2905394 SGTC_1139 k015-0024 46.9 µM 2766652 SGTC_1243 0416-0003 5.65 µM 2141977 SGTC_1277 0873-0036 22 µM 5965735 SGTC_1307 1187-1599 12.2 µM 1538471 SGTC_1648 st011736 69.8 µM 2855514 SGTC_1700 st030840 7.93 µM 5499307 SGTC_1810 st050138 53 µM 3444541 SGTC_196 k015-0023 18.11 µM 5211998 SGTC_202 3594-0513 34.79 µM 708429 SGTC_2481 5478948 45.16 µM 77792 SGTC_2482 5981709 142.65 µM 877755 SGTC_250 brefeldin a 552.24 µM 6436187 SGTC_2508 celastrol 40.54 µM 122724 SGTC_295 k015-0027 31 µM 3887424 SGTC_3025 9087895 49.47 µM 17173641 SGTC_3241 9133421 49.47 µM 17018221 SGTC_3256 9138902 49.47 µM 17228773 SGTC_489 paxilline 115 µM 105008 SGTC_527 4476-4215 268 µM 4418754 SGTC_533 1222-0222 6.71 µM 3982874 SGTC_619 1652-1634 108 µM 5400454 SGTC_687 k029-0044 34.9 µM 5829338 SGTC_722 3534-0461 190 µM 658262 SGTC_854 0422-0053 192 µM 3596728 SGTC_935 2996-0153 430 µM 23738523
▶	plasma membrane duress	piperazine-induced plasma membrane duress	18
	Screen ID Conditions Concentration Pubchem CID SGTC_1005 4092-0690 4.4 µM 1529343 SGTC_1160 4092-0570 10.5 µM 4994975 SGTC_1435 4092-0789 56.7 µM 2248285 SGTC_1455 4262-0120 131 µM 1529587 SGTC_1475 4092-1048 11.7 µM 2881759 SGTC_1999 st074831 12.5 µM 17112523 SGTC_2038 4100038 30.99 µM 3596803 SGTC_2721 ifenprodil 61.44 µM 3689 SGTC_2725 haloperidol 53.21 µM 3559 SGTC_2733 amorolfine 100 µM 54260 SGTC_2735 sertaconazole 140 nM 65863 SGTC_278 4092-0821 23.9 µM 877900 SGTC_2910 7948405 25.97 µM 2971328 SGTC_2948 9070189 9.45 µM 6473636 SGTC_308 4092-1169 104 µM 2268590 SGTC_3308 9128332 17.57 µM 17332805 SGTC_515 4092-1064 102 µM 717353 SGTC_646 4092-0839 27.3 µM 877796
▶	redox potentiating	protein catabolism via the multivesicular body sorting pathway associated with the generation of superoxide	27
	Screen ID Conditions Concentration Pubchem CID SGTC_102 gallobenzophenone 83.62 µM 70837 SGTC_1083 didemethylchlorpromazine sulfoxide 707.39 nM 398788 SGTC_117 lucigenin 22.08 µM 65100 SGTC_1174 0739-0097 51.1 µM 728447 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 442882 SGTC_1615 st002656 86.5 µM 1584458 SGTC_1718 roemerine 11.93 µM 235224 SGTC_1884 5633444 25 µM 5724239 SGTC_1962 st076595 64.5 µM 279619 SGTC_2 0422-0095 29 µM 6790840 SGTC_2016 5121758 140 µM 2795203 SGTC_2485 5633444 17.78 µM 5724239 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 4000243 SGTC_2582 agaric acid 100 µM 12629 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 6708739 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 269315 SGTC_2661 dactinomycin 12.96 µM 45006140 SGTC_3 0833-0587 95.58 µM 5382644 SGTC_3041 9091929 49.47 µM 25236887 SGTC_3110 9122132 49.47 µM 918317 SGTC_3296 9122258 64.05 µM 4730474 SGTC_525 k781-2675 26.7 µM 3651118 SGTC_576 1073-0113 22.7 µM 5439563 SGTC_660 4031-1742 102 µM 6738706 SGTC_748 0136-0228 77.9 µM 4421505 SGTC_859 0439-0102 54.6 µM 610143 SGTC_978 1416-0512 87.4 µM 6814003
▶	RNA pol III & RNase P/MRP	responses associated with RNA polymerase III and other complexes	17
	Screen ID Conditions Concentration Pubchem CID SGTC_1016 4226-1401 38 µM 2901613 SGTC_1522 st012842 45.6 µM 3491067 SGTC_1534 6-azauridine 81.6 µM 233502 SGTC_1872 amphotericin b 148 nM 16667679 SGTC_1915 st067105 30.6 µM 69751 SGTC_1930 st074634 34.3 µM 684253 SGTC_2411 st077133 39.94 µM 1403142 SGTC_2522 biochanin a 4.94 µM 5280373 SGTC_2544 sphondin 68.51 µM 108104 SGTC_2612 dictamnine 15.46 µM 68085 SGTC_2685 mycophenolic acid 18.85 µM 446541 SGTC_2738 aclarubicin 5.55 µM 451415 SGTC_392 N-ethylmaleimide 8.33 µM 4362 SGTC_539 4859-0462 2.54 µM 46499474 SGTC_597 k018-0003 82.8 µM 6786234 SGTC_678 1218-2179 85.9 µM 6820081 SGTC_919 tnp00227 403.57 nM 1269246
▶	RNA processing & uracil transport	strong requirement for FUR4, a uracil transporter, and RNA processing genes GLC7 and RRP45; no other signature genes	29
	Screen ID Conditions Concentration Pubchem CID SGTC_1167 k781-0610 148 µM 4525169 SGTC_1202 1988-0068 29.6 µM 2850480 SGTC_122 0236-0016 402.4 µM 6808838 SGTC_1261 0712-0010 12.7 µM 2840123 SGTC_1471 k673-0312 37 µM 24099884 SGTC_1745 st081495 74 µM 13842402 SGTC_1774 st048371 48.47 µM 4242727 SGTC_1814 st052110 31.54 µM 674163 SGTC_1817 st052116 64.4 µM 4361398 SGTC_1950 st077106 7.18 µM 13831864 SGTC_1951 sophoraflavanone G 9.2 µM 9910234 SGTC_2082 5219693 150 µM 2834649 SGTC_2192 5915882 198.49 µM 2876149 SGTC_2220 6782180 200 µM 833803 SGTC_2292 7671323 168.05 µM 937504 SGTC_2297 7971671 152.32 µM 909016 SGTC_2342 7990637 118.86 µM 2033102 SGTC_2351 9026858 72.31 µM 1409300 SGTC_2393 9031399 185.94 µM 1526623 SGTC_2970 9090938 41.86 µM 17217104 SGTC_305 1682-2595 20.8 µM 226033 SGTC_3074 9116018 49.47 µM 17027303 SGTC_3341 9147222 25.87 µM 1939759 SGTC_3355 9151058 44.05 µM 17015728 SGTC_398 bronopol 33.3 µM 2450 SGTC_452 diindolylmethane 8 µM 3071 SGTC_53 0973-0023 39.98 µM 674768 SGTC_809 3998-0021 90 µM 715485 SGTC_923 1900-2434 73.3 µM 5910570
▶	RPP1 & pyrimidine depletion	notable drug-induced haploinsufficiency of RPP1, a member of RNase P and MRP, complexes that cleave rRNA and tRNA precursors, respectively	85
	Screen ID Conditions Concentration Pubchem CID SGTC_1094 duloxetine 25.4 µM 60834 SGTC_1115 galangin 695.68 nM 5281616 SGTC_1273 0849-0096 14.1 µM 5286025 SGTC_132 0417-1715 25.81 µM 6769098 SGTC_1361 1608-0041 5.61 µM SGTC_1369 1866-0067 208 µM 3531355 SGTC_1385 3091-4834 14.1 µM 4072814 SGTC_1399 3562-5772 25 µM 23847490 SGTC_1449 4112-4002 201 µM 2059539 SGTC_1485 3909-9022 254 µM 714516 SGTC_1488 4013-0813 75.9 µM 2910057 SGTC_1500 4488-1866 171 µM 2900003 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 2724278 SGTC_1601 4'-hydroxyflavanone 55.5 µM 165506 SGTC_1629 st005085 44.9 µM 24207091 SGTC_1642 st009582 77.7 µM 6739311 SGTC_1668 st014914 51.6 µM 2839556 SGTC_1766 st045414 44.77 µM 253960 SGTC_1771 st048882 4.15 µM 4580403 SGTC_1820 st053765 18.6 µM 3690829 SGTC_1834 st055981 52.8 µM 471719 SGTC_1849 st056239 19.2 µM 5393181 SGTC_1850 st056238 17 µM 5393177 SGTC_1908 st060353 56.5 µM 4227716 SGTC_1959 st077091 55.8 µM 821356 SGTC_1964 st076914 61 µM 24208661 SGTC_1965 Pectolinarigenin 58.4 µM 5320438 SGTC_1979 st071809 45.3 µM 4976333 SGTC_1980 st071811 45.7 µM 4974850 SGTC_1983 st071813 46.9 µM 11838595 SGTC_2057 5236571 38.34 µM 54684039 SGTC_2135 5326629 150.42 µM 5020077 SGTC_2156 5649887 115 µM 54680440 SGTC_2189 6047310 154.43 µM 711535 SGTC_2270 7924575 90.91 µM 1262135 SGTC_2282 7944268 200 µM 2970414 SGTC_2306 7482397 179.52 µM 891448 SGTC_2313 7726885 200 µM 726423 SGTC_2360 9040895 200 µM 4914414 SGTC_2498 4'-Methoxychalcone 54.63 µM 641818 SGTC_2504 purpurogallin 52.29 µM 5281571 SGTC_2505 galangin 7.89 µM 5281616 SGTC_2506 ethyl hematommate 54.16 µM 3940691 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 5098884 SGTC_2515 chrysin 20.77 µM 5281607 SGTC_265 mycophenolic acid 32.93 µM 446541 SGTC_2686 alizarin 95.37 µM 6293 SGTC_27 0485-0001 32.62 µM 2054479 SGTC_2743 auranofin 4.32 µM 16667669 SGTC_2791 5663188 71.43 µM 54690634 SGTC_2800 7887935 81.82 µM 2961002 SGTC_2836 9010338 19.48 µM 2994051 SGTC_2860 9025725 38.96 µM 40546248 SGTC_2985 9022375 71.43 µM 4939335 SGTC_2987 9018338 71.43 µM 5055682 SGTC_2994 9053520 71.43 µM 4647384 SGTC_2998 9066762 71.43 µM 4945196 SGTC_3039 9090270 49.47 µM 17173750 SGTC_3112 9123419 49.47 µM 17015854 SGTC_3167 9103034 49.47 µM 5127859 SGTC_3169 9102970 49.47 µM 17027839 SGTC_3182 9108849 49.47 µM 17133045 SGTC_3183 9108214 49.47 µM 4974831 SGTC_3186 9110464 49.47 µM 17018021 SGTC_321 4534-3890 65.3 µM 699746 SGTC_3216 9129716 49.47 µM 8056934 SGTC_3224 9130643 49.47 µM 17644395 SGTC_3232 9132874 49.47 µM 3784940 SGTC_3261 9137475 49.47 µM 17027690 SGTC_3270 9137563 49.47 µM 17015724 SGTC_3281 9140613 49.47 µM 16013766 SGTC_330 1488-0319 80.1 µM 6846614 SGTC_347 4534-1311 26.2 µM 2862016 SGTC_362 0310-0100 9.03 µM 790235 SGTC_466 geldanamycin 89.2 µM 5288382 SGTC_600 1495-0418 41.6 µM 5377768 SGTC_667 1498-1044 59 µM 6739982 SGTC_680 0417-1641 114 µM 2835990 SGTC_72 0744-0168 198.39 µM 677577 SGTC_756 0508-1999 28.3 µM 6753853 SGTC_770 0389-1121 67.2 µM 6753108 SGTC_797 k781-0471 270 µM 23738129 SGTC_828 2074-0507 139 µM SGTC_975 1335-0046 28.5 µM 16486740 SGTC_995 3931-2021 34.6 µM 730143
▼	RSC & ERG11	RSC chromatin structure remodeling complex and ERG11, an ergosterol biosynthesis enzyme	16
	Screen ID Conditions Concentration Pubchem CID SGTC_185 k048-0037 25.49 µM 6827589 SGTC_1870 st057514 26.5 µM 5393161 SGTC_203 k066-0004 30.89 µM 6795412 SGTC_288 1315-0019 35.1 µM 6811474 SGTC_319 1348-1596 45.5 µM 5380505 SGTC_322 k048-0136 19.3 µM 6823282 SGTC_324 1315-0088 19.6 µM 6787421 SGTC_329 k048-0121 21.3 µM 6832902 SGTC_331 k048-0133 24.5 µM 6813582 SGTC_342 k048-0088 23.3 µM 6820570 SGTC_566 0958-0068 16.5 µM 6815365 SGTC_590 k048-0076 22.4 µM 6832814 SGTC_643 k048-0106 28.4 µM 6763920 SGTC_746 1095-0025 46.6 µM 6749286 SGTC_783 0848-0141 92.7 µM 6755076 SGTC_970 1315-0089 19.5 µM 6811083
▶	RSC complex & mRNA processing	RSC chromatin structure remodeling complex and mRNA processing	24
	Screen ID Conditions Concentration Pubchem CID SGTC_1050 3232-1156 69.3 µM 700529 SGTC_1133 3473-0247 50 µM 711311 SGTC_1229 0139-0193 12.2 µM 3090752 SGTC_1374 2889-5571 141 µM 2853281 SGTC_1493 4348-0038 111 µM 800424 SGTC_1651 st011928 86.1 µM 720198 SGTC_1652 st011932 78 µM 1551076 SGTC_2041 5107442 45.34 µM 793005 SGTC_2109 5483026 200 µM 759335 SGTC_2140 5586273 200 µM 854421 SGTC_2180 6301957 200 µM 845462 SGTC_2186 6124449 200 µM 3834182 SGTC_2187 6125751 200 µM 874498 SGTC_2229 7354935 190 µM 318112 SGTC_2277 7947813 106.88 µM 1246798 SGTC_2361 9034121 116 µM 6496917 SGTC_237 nikkomycin 200 µM 353481 SGTC_2378 9074213 121.43 µM 657714 SGTC_2396 5342950 42.78 µM 1886677 SGTC_2400 5203494 178.7 µM 6777674 SGTC_2534 helenine 20.12 µM 72724 SGTC_673 1082-0474 110 µM 3098046 SGTC_709 3807-1509 243 µM 1886677 SGTC_839 0122-0028 230 µM 759448
▶	sphingolipid biosynthesis & PDR1	responses associated with sphingolipid biosynthesis and PDR1, a transcription factor that regulates the pleiotropic drug response (induced by surfactants)	14
	Screen ID Conditions Concentration Pubchem CID SGTC_1287 0971-0001 34.6 µM 4665869 SGTC_1568 digitonin 820 nM 2735010 SGTC_1941 st076221 61.8 µM 2828568 SGTC_2248 tofa 1.1 µM 115175 SGTC_2416 tofa 880 nM 115175 SGTC_2581 avocatin a 64 µM 6710728 SGTC_266 formosanin C 406 nM 73597 SGTC_2858 9025781 8.96 µM 4894980 SGTC_470 aa-861 153 µM 1967 SGTC_628 1636-0253 16 µM 4456143 SGTC_664 1222-0054 14.9 µM 6813991 SGTC_683 panaxydol 45 µM 5283280 SGTC_804 1595-0054 20.9 µM 761523 SGTC_955 1216-0110 33 µM 3619719
▶	superoxide	pentose phosphate pathway/NADP metabolism	13
	Screen ID Conditions Concentration Pubchem CID SGTC_1552 6-methylflavone 10.6 µM 689013 SGTC_1556 plumbagin 1.48 µM 10205 SGTC_2085 5307070 144.05 µM 2840351 SGTC_2089 5281248 129.67 µM 2737878 SGTC_2139 5578692 56.47 µM 650991 SGTC_2214 7179297 48.28 µM 769744 SGTC_2223 6903751 107.57 µM 5598863 SGTC_2259 7964009 200 µM 313134 SGTC_2575 plumbagin 510 nM 10205 SGTC_2681 menadione 3.18 µM 4055 SGTC_2799 7812892 81.82 µM 20205235 SGTC_394 menadione 8.33 µM 4055 SGTC_799 1310-0557 151 µM 5354492
▶	SWF1 & branched chain AA biosynthesis	branched chain amino acid biosynthesis and protein modification via SWF1	9
	Screen ID Conditions Concentration Pubchem CID SGTC_107 0358-0022 2.69 µM 521106 SGTC_1218 1348-1416 30.7 µM 6787668 SGTC_1696 st025591 34.79 µM 2787147 SGTC_2034 5197015 53.07 µM 780676 SGTC_2043 5101342 149 µM 678451 SGTC_2132 5317594 122.67 µM 794577 SGTC_34 0469-0683 81.75 µM 3690923 SGTC_796 1234-0020 70.7 µM 46495034 SGTC_984 1492-0255 2.91 µM 1585198
▶	translation	cytoplasmic and mitochondrial translation	6
	Screen ID Conditions Concentration Pubchem CID SGTC_118 0083-0097 135.34 µM 5207356 SGTC_625 k213-0058 121 µM 3655420 SGTC_800 3448-7362 155 µM 15991913 SGTC_830 4076-0286 57.8 µM 6866659 SGTC_831 k061-1017 217 µM 1240153 SGTC_832 4083-0019 164 µM 1990758
▶	TRP & mitochondrial translation	thiazolidinone targeting of protein prenylation (RER2) dirupts mitochondrial function	14
	Screen ID Conditions Concentration Pubchem CID SGTC_10 0279-0212 42.58 µM 39851 SGTC_1881 5652484 16 µM 2255129 SGTC_1882 5615643 20 µM 2253075 SGTC_1883 5-benzylidenerhodanine 20 µM 1273210 SGTC_19 0279-0214 38.43 µM 3566274 SGTC_1921 5740136 50 µM 1774243 SGTC_1922 5578187 25 µM 1350412 SGTC_204 1543-0184 62.41 µM 2252213 SGTC_2232 chlorophetanol 41.54 µM 15907 SGTC_2454 5-benzylidenerhodanine 10.36 µM 1273210 SGTC_2472 5377652 49.4 µM 1610903 SGTC_596 1155-0152 116 µM 280313 SGTC_767 0929-0023 86 µM 1204563 SGTC_892 0929-0076 29 µM 5751038
▶	TSC3-RPN4	responses associated with a strong requirement for TSC3 (activator of sphingolipid biosynthesis) and a moderate requirement for RPN4 (transcription factor that stimulates expression of proteasome genes)	59
	Screen ID Conditions Concentration Pubchem CID SGTC_1013 4112-3890 241 µM 705171 SGTC_1023 4482-3888 16 µM 3303168 SGTC_1024 4507-0395 26 µM 4201836 SGTC_1030 k029-0042 36.7 µM 6080581 SGTC_1042 0350-0096 82 µM 3122515 SGTC_1080 nisoldipine 24.4 µM 4499 SGTC_1119 parthenolide 318.54 nM 5702252 SGTC_1173 0443-0020 122 µM 5331295 SGTC_1222 0366-0074 1.18 µM 286520 SGTC_1299 1079-1439 3.74 µM 323161 SGTC_1332 1480-0653 17.5 µM 5749438 SGTC_1603 st002045 67.8 µM 5887985 SGTC_1604 st002052 72.4 µM 6254834 SGTC_1634 st006576 41 µM 3915356 SGTC_1662 st014054 52 µM 2838777 SGTC_1685 st024049 53.09 µM 1941139 SGTC_1706 st031321 9.97 µM 6103185 SGTC_1738 st035555 74 µM 5331140 SGTC_1795 st049545 62.3 µM 5291882 SGTC_1813 st051246 8.6 µM 5291959 SGTC_1815 st051655 58.2 µM 5984156 SGTC_1845 st056753 3.01 µM 5375839 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 756377 SGTC_1891 st059073 26.2 µM 688754 SGTC_1919 st067113 52.3 µM 1268243 SGTC_1925 st057770 10.1 µM 5989122 SGTC_1970 st070122 35.8 µM 102928 SGTC_1978 st071761 42 µM 5147680 SGTC_2071 5230951 39.92 µM 1799272 SGTC_2090 5301565 104.45 µM 2056344 SGTC_2092 5303694 80.67 µM 1963699 SGTC_2110 5483698 200 µM 2848765 SGTC_2112 5488546 200 µM 600757 SGTC_2113 5491891 107.03 µM 789979 SGTC_2217 6934799 96.07 µM 675606 SGTC_2218 6965428 192.98 µM 675684 SGTC_235 0330-0087 5 mM 46494818 SGTC_2552 juarezic acid 87.02 µM 1549512 SGTC_2592 piperlongumine 83.33 µM 637858 SGTC_2627 acetyl isogambogic acid 100 µM 6857789 SGTC_28 pentachloropyridine N-oxide 1.61 µM 140250 SGTC_2949 9072542 2.23 µM 16457352 SGTC_32 0928-0142 34.1 µM 2244242 SGTC_3236 9132701 49.47 µM 24282524 SGTC_328 k915-0120 63.5 µM 6624543 SGTC_428 3448-4153 16.5 µM 3834874 SGTC_47 0149-0135 24.25 µM 5239155 SGTC_503 tyrphostin 8 294 µM 92970 SGTC_52 0329-0193 875 nM 3739292 SGTC_548 1436-0017 110 µM 9677137 SGTC_550 4123-0385 25.7 µM 5731123 SGTC_720 r052-1644 49.9 µM 1422863 SGTC_752 1896-0090 130 µM 772567 SGTC_762 1165-0429 115 µM 5967793 SGTC_77 0828-0286 12.52 µM 745345 SGTC_790 1575-0012 79.1 µM 378741 SGTC_885 0865-0106 16.8 µM 2793380 SGTC_926 2268-1401 59.4 µM 2931578 SGTC_985 1493-0307 8.71 µM 3278274
▶	tubulin folding & SWR complex	tubulin biogenesis, induced by tubulin inhibitors benomyl and nocodazole	26
	Screen ID Conditions Concentration Pubchem CID SGTC_1132 3456-3614 2.5 µM 3125502 SGTC_1326 1431-2094 10.8 µM 616278 SGTC_1352 1496-0991 99 µM 3000039 SGTC_1401 3807-4679 7.6 µM 3291456 SGTC_1433 4060-0023 7.6 µM 3840627 SGTC_149 3970-0822 46.1 µM 3114250 SGTC_1875 nocodazole 6 µM 4122 SGTC_2061 5245884 80.95 µM 573863 SGTC_212 3807-4682 38.77 µM 3125501 SGTC_2125 5246583 200 µM 835267 SGTC_2141 5621638 7.67 µM 2856238 SGTC_2161 5662504 8.51 µM 2859334 SGTC_2166 5933061 31.5 µM 2877375 SGTC_2173 5763948 167 µM 2867177 SGTC_2174 5790901 200 µM 786020 SGTC_2200 6600604 21.91 µM 2904777 SGTC_2269 7935389 174.42 µM 97605 SGTC_229 benomyl 22.87 µM 28780 SGTC_2319 6033012 152.6 µM 847246 SGTC_2352 9027995 87.8 µM 2997347 SGTC_286 k060-0067 22.9 µM 5985051 SGTC_2947 9072639 7.68 µM 16488146 SGTC_2952 9073731 13.78 µM 16457353 SGTC_3294 9122953 26.28 µM 16459826 SGTC_375 3970-0961 9.27 µM 2898222 SGTC_379 3970-0972 5.9 µM 2898042
▶	ubiquinone biosynthesis & proteasome	responses associated with the 20S proteosome, ubiquinone biosynthesis and an adamantyl structure moiety	18
	Screen ID Conditions Concentration Pubchem CID SGTC_137 0438-0332 85.39 µM 2063393 SGTC_142 0335-0849 62.67 µM 3889043 SGTC_158 k038-0087 26.45 µM SGTC_165 k038-0023 64.38 µM 46368543 SGTC_200 k038-0079 37.55 µM 3436683 SGTC_216 k038-0035 28.38 µM 4444231 SGTC_294 k038-0071 157 µM 24152826 SGTC_340 k038-0059 454 µM 23733424 SGTC_36 0335-0881 14.2 µM 23828853 SGTC_367 0335-0881 7.1 µM 23828853 SGTC_635 k038-0028 24.7 µM 4035102 SGTC_64 000l-0018 272.08 µM 6811119 SGTC_642 0335-0876 158 µM 6812350 SGTC_67 0335-0847 266 µM 4552207 SGTC_794 k038-0031 316 µM 6624242 SGTC_837 0091-0265 12.5 µM 759367 SGTC_846 0335-0850 148 µM 6819598 SGTC_86 0417-1630 471.92 µM 3634867
▶	unfolded protein response	unfolded protein response induced by inhibition of diverse HIP targets	11
	Screen ID Conditions Concentration Pubchem CID SGTC_112 phenothiazine 287.22 µM 7108 SGTC_1239 0337-0584 35.4 µM 914301 SGTC_16 erodoxin 22.81 µM 3967339 SGTC_1789 tunicamycin 25 nM 23847177 SGTC_22 0964-0034 14.47 µM 138402 SGTC_255 tunicamycin 200.47 nM 23847177 SGTC_2997 9067075 71.43 µM 27209819 SGTC_3078 9116413 49.47 µM 17177322 SGTC_353 1988-1175 58.3 µM 2788357 SGTC_513 4245-1575 41.7 µM 719745 SGTC_531 3788-1495 174 µM 2896655