Major Responses

The major response signatures can be explored in detail in the network of response signatures (i.e. a web version of fig. 2).
GO TO network of response signatures

Major response signatures and their associated screens are indicated below (click on arrow to view screens).


Response SignatureDescriptionNumber
of
Screens
60S ribosome export LSG1-NMD3 mediated ribosomal export from the nucleus 102
amide catabolism responses associated with DAL81, a nitrogen catabolite activator 32
anthracycline transcription coupled DNA repair responses associated with SSL2, a member of RNA polymerase transcription factor TFIIH holoenzyme, and DNA damage 7
azole & statin sterol biosynthesis, induced by ergosterol pathway inhibitors such as azoles and statins 26
calcium & mitochondrial duress calcium stress response, includes IMP2', a transcriptional activator involved in ion homeostasis 38
cell wall regulation of cell wall organization 31
cell wall signaling protein kinase C signaling 25
copper-dependent oxidative stress copper transport induced by oxidative stress and copper-dependent SOD1, SOD2 25
DNA damage response DNA damage and repair 34
DNA intercalators responses associated with ERG12 (ergosterol biosynthesis), YMR166C (potential mitochondrial carrier), EFM1 (lysine methyltransferase of eIF1A) and CEP3 (kineticore protein) 27
endomembrane recycling responses associated with RCY1, a protein involved in recycling plasma membrane proteins, and (amino)phospholipid transport 31
ERAD & cell cycle endoplasmic reticulum-associated degradation and cell cycle 11
ERG2 responses associated with ERG2, involved in ergosterol biosynthesis; deletion increases membrane permeability; no other signature genes 49
ergosterol biosynthesis ergosterol biosynthesis 20
ergosterol depletion effects on membrane effects of high concentrations of ergosterol inhibitors on plasma membrane (e.g. vesicular trafficking, sterol biosynthesis) and regulation of GTPase activity 15
excess fatty acid response to excess fatty acid, primarily through LRO1, an acyltransferase that catalyzes diacylglycerol esterification 9
exosome exosome complex; induced by uracil analogs such as 5-fluorouracil 7
fatty acid desaturase (OLE1) responses associated with drug-induced happloinsufficiency of OLE1 (fatty acid desaturase) 36
Golgi intra-Golgi transport involving the COG1-8 Golgi transport complex 71
heat shock/prefoldin responses associated with the prefoldin complex, induced by heat shock 5
heme biosynthesis & mitochondrial translocase heme biosynthesis and the mitchondrial outer membrane translocase complex 19
heme requiring responses associated with heme biosynthesis, induced by compounds such as the iron chelator bathophenantroline 14
iron homeostasis responses associated with iron homeostasis, induced by several iron chelators 35
mitochondrial processes responses associated with mitochondrial processes including ATPase inhibition 53
mitochondrial response to ROS responses associated with mitochondrial genome maintenance, induced by compounds such as the antioxidant mangostin, which may participate in redox cycling 16
mitochondrial stress disruption of mitochondrial processes, associated with charged and reactive compounds 10
NEO1 notable drug-induced haploinsufficiency of NEO1, an aminophospholipid plasma membrane flippase 21
NEO1-PIK1 drug-induced haploinsufficiency of NEO1 (aminophospholipid plasma membrane flippase) and PIK1 (phosphatidylinositol 4-kinase) 17
PDR1 notable requirement for PDR1, a transcription factor that regulates the pleiotropic drug response; no other signature genes 26
plasma membrane duress piperazine-induced plasma membrane duress 18
redox potentiating protein catabolism via the multivesicular body sorting pathway associated with the generation of superoxide 27
RNA pol III & RNase P/MRP responses associated with RNA polymerase III and other complexes 17
RNA processing & uracil transport strong requirement for FUR4, a uracil transporter, and RNA processing genes GLC7 and RRP45; no other signature genes 29
RPP1 & pyrimidine depletion notable drug-induced haploinsufficiency of RPP1, a member of RNase P and MRP, complexes that cleave rRNA and tRNA precursors, respectively 85
Screen IDConditionsConcentrationPubchem CID
SGTC_1094duloxetine25.4 µM60834
SGTC_1115galangin695.68 nM5281616
SGTC_12730849-009614.1 µM5286025
SGTC_1320417-171525.81 µM6769098
SGTC_13611608-00415.61 µM
SGTC_13691866-0067208 µM3531355
SGTC_13853091-483414.1 µM4072814
SGTC_13993562-577225 µM23847490
SGTC_14494112-4002201 µM2059539
SGTC_14853909-9022254 µM714516
SGTC_14884013-081375.9 µM2910057
SGTC_15004488-1866171 µM2900003
SGTC_1535tetrahydropapaveroline hydrobromide54.3 µM2724278
SGTC_16014'-hydroxyflavanone55.5 µM165506
SGTC_1629st00508544.9 µM24207091
SGTC_1642st00958277.7 µM6739311
SGTC_1668st01491451.6 µM2839556
SGTC_1766st04541444.77 µM253960
SGTC_1771st0488824.15 µM4580403
SGTC_1820st05376518.6 µM3690829
SGTC_1834st05598152.8 µM471719
SGTC_1849st05623919.2 µM5393181
SGTC_1850st05623817 µM5393177
SGTC_1908st06035356.5 µM4227716
SGTC_1959st07709155.8 µM821356
SGTC_1964st07691461 µM24208661
SGTC_1965Pectolinarigenin58.4 µM5320438
SGTC_1979st07180945.3 µM4976333
SGTC_1980st07181145.7 µM4974850
SGTC_1983st07181346.9 µM11838595
SGTC_2057523657138.34 µM54684039
SGTC_21355326629150.42 µM5020077
SGTC_21565649887115 µM54680440
SGTC_21896047310154.43 µM711535
SGTC_2270792457590.91 µM1262135
SGTC_22827944268200 µM2970414
SGTC_23067482397179.52 µM891448
SGTC_23137726885200 µM726423
SGTC_23609040895200 µM4914414
SGTC_24984'-Methoxychalcone54.63 µM641818
SGTC_2504purpurogallin52.29 µM5281571
SGTC_2505galangin7.89 µM5281616
SGTC_2506ethyl hematommate54.16 µM3940691
SGTC_2509methyl 7-deshydroxypyrogallin-4-carboxylate54.59 µM5098884
SGTC_2515chrysin20.77 µM5281607
SGTC_265mycophenolic acid32.93 µM446541
SGTC_2686alizarin95.37 µM6293
SGTC_270485-000132.62 µM2054479
SGTC_2743auranofin4.32 µM16667669
SGTC_2791566318871.43 µM54690634
SGTC_2800788793581.82 µM2961002
SGTC_2836901033819.48 µM2994051
SGTC_2860902572538.96 µM40546248
SGTC_2985902237571.43 µM4939335
SGTC_2987901833871.43 µM5055682
SGTC_2994905352071.43 µM4647384
SGTC_2998906676271.43 µM4945196
SGTC_3039909027049.47 µM17173750
SGTC_3112912341949.47 µM17015854
SGTC_3167910303449.47 µM5127859
SGTC_3169910297049.47 µM17027839
SGTC_3182910884949.47 µM17133045
SGTC_3183910821449.47 µM4974831
SGTC_3186911046449.47 µM17018021
SGTC_3214534-389065.3 µM699746
SGTC_3216912971649.47 µM8056934
SGTC_3224913064349.47 µM17644395
SGTC_3232913287449.47 µM3784940
SGTC_3261913747549.47 µM17027690
SGTC_3270913756349.47 µM17015724
SGTC_3281914061349.47 µM16013766
SGTC_3301488-031980.1 µM6846614
SGTC_3474534-131126.2 µM2862016
SGTC_3620310-01009.03 µM790235
SGTC_466geldanamycin89.2 µM5288382
SGTC_6001495-041841.6 µM5377768
SGTC_6671498-104459 µM6739982
SGTC_6800417-1641114 µM2835990
SGTC_720744-0168198.39 µM677577
SGTC_7560508-199928.3 µM6753853
SGTC_7700389-112167.2 µM6753108
SGTC_797k781-0471270 µM23738129
SGTC_8282074-0507139 µM
SGTC_9751335-004628.5 µM16486740
SGTC_9953931-202134.6 µM730143

RSC & ERG11 RSC chromatin structure remodeling complex and ERG11, an ergosterol biosynthesis enzyme 16
RSC complex & mRNA processing RSC chromatin structure remodeling complex and mRNA processing 24
sphingolipid biosynthesis & PDR1 responses associated with sphingolipid biosynthesis and PDR1, a transcription factor that regulates the pleiotropic drug response (induced by surfactants) 14
superoxide pentose phosphate pathway/NADP metabolism 13
SWF1 & branched chain AA biosynthesis branched chain amino acid biosynthesis and protein modification via SWF1 9
translation cytoplasmic and mitochondrial translation 6
TRP & mitochondrial translation thiazolidinone targeting of protein prenylation (RER2) dirupts mitochondrial function 14
TSC3-RPN4 responses associated with a strong requirement for TSC3 (activator of sphingolipid biosynthesis) and a moderate requirement for RPN4 (transcription factor that stimulates expression of proteasome genes) 59
tubulin folding & SWR complex tubulin biogenesis, induced by tubulin inhibitors benomyl and nocodazole 26
ubiquinone biosynthesis & proteasome responses associated with the 20S proteosome, ubiquinone biosynthesis and an adamantyl structure moiety 18
unfolded protein response unfolded protein response induced by inhibition of diverse HIP targets 11