Major Responses

The major response signatures can be explored in detail in the network of response signatures (i.e. a web version of fig. 2).
GO TO network of response signatures

Major response signatures and their associated screens are indicated below (click on arrow to view screens).


Response SignatureDescriptionNumber
of
Screens
60S ribosome export LSG1-NMD3 mediated ribosomal export from the nucleus 102
amide catabolism responses associated with DAL81, a nitrogen catabolite activator 32
anthracycline transcription coupled DNA repair responses associated with SSL2, a member of RNA polymerase transcription factor TFIIH holoenzyme, and DNA damage 7
azole & statin sterol biosynthesis, induced by ergosterol pathway inhibitors such as azoles and statins 26
calcium & mitochondrial duress calcium stress response, includes IMP2', a transcriptional activator involved in ion homeostasis 38
cell wall regulation of cell wall organization 31
cell wall signaling protein kinase C signaling 25
copper-dependent oxidative stress copper transport induced by oxidative stress and copper-dependent SOD1, SOD2 25
DNA damage response DNA damage and repair 34
DNA intercalators responses associated with ERG12 (ergosterol biosynthesis), YMR166C (potential mitochondrial carrier), EFM1 (lysine methyltransferase of eIF1A) and CEP3 (kineticore protein) 27
endomembrane recycling responses associated with RCY1, a protein involved in recycling plasma membrane proteins, and (amino)phospholipid transport 31
ERAD & cell cycle endoplasmic reticulum-associated degradation and cell cycle 11
ERG2 responses associated with ERG2, involved in ergosterol biosynthesis; deletion increases membrane permeability; no other signature genes 49
ergosterol biosynthesis ergosterol biosynthesis 20
ergosterol depletion effects on membrane effects of high concentrations of ergosterol inhibitors on plasma membrane (e.g. vesicular trafficking, sterol biosynthesis) and regulation of GTPase activity 15
excess fatty acid response to excess fatty acid, primarily through LRO1, an acyltransferase that catalyzes diacylglycerol esterification 9
exosome exosome complex; induced by uracil analogs such as 5-fluorouracil 7
fatty acid desaturase (OLE1) responses associated with drug-induced happloinsufficiency of OLE1 (fatty acid desaturase) 36
Golgi intra-Golgi transport involving the COG1-8 Golgi transport complex 71
Screen IDConditionsConcentrationPubchem CID
SGTC_1034k072-016512.7 µM5835461
SGTC_1035k081-004155.2 µM731709
SGTC_1039k821-004394 µM15992768
SGTC_10603448-735082 µM570178
SGTC_1078idebenone36.1 µM3686
SGTC_1162k048-013020.1 µM6797406
SGTC_11760848-013183.3 µM6769040
SGTC_12011889-337245.9 µM5392199
SGTC_12380333-028748.8 µM7226
SGTC_13061185-02709.02 µM1548076
SGTC_13251431-0015227 µM1103340
SGTC_13631636-006310.4 µM6072185
SGTC_13732887-000358.5 µM776948
SGTC_14083909-797648.8 µM24152374
SGTC_1460k062-00599.15 µM1373085
SGTC_15324',5'-dihydroxyflavone78.7 µM165521
SGTC_1581himbacine57.9 µM5281825
SGTC_1631benzylvanillin81.9 µM75506
SGTC_1667st01484934.6 µM5348460
SGTC_1669st01524958.4 µM722793
SGTC_16794130-12766.7 µM1005053
SGTC_1735st03431056.75 µM871153
SGTC_1751st04483927.19 µM5291326
SGTC_1783st03945987.52 µM729761
SGTC_1917st06650728.5 µM3156428
SGTC_20305175110200 µM2831986
SGTC_21826325192200 µM736248
SGTC_2242663044961.27 µM691249
SGTC_23469031566143.75 µM4771086
SGTC_23639053361176 µM6469797
SGTC_2495cafestol54.53 µM16667697
SGTC_2543pimpinellin60.67 µM4825
SGTC_2737bleomycin30.5 nM16211318
SGTC_2811672-344014.9 µM6833000
SGTC_2890904672958.44 µM903329
SGTC_2900532852885.29 µM795359
SGTC_2902578700660.46 µM591003
SGTC_2914130-127835.5 µM1068044
SGTC_2923799265458.14 µM2985126
SGTC_3053909590349.47 µM17174018
SGTC_3057909594649.47 µM24540043
SGTC_3061672-343611.6 µM6797378
SGTC_3098911903949.47 µM17161528
SGTC_3149909785549.47 µM25236625
SGTC_3166910229749.47 µM25237072
SGTC_3187910939449.47 µM17098090
SGTC_3219913111249.47 µM17612988
SGTC_3277913872449.47 µM15943418
SGTC_3310913022944.14 µM7761258
SGTC_3325913876055.18 µM43844959
SGTC_3338914430039.57 µM4901274
SGTC_3660181-02064.31 µM274874
SGTC_40960-023425.67 µM6821112
SGTC_4982,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)150 µM2374
SGTC_5382922-083853.3 µM777039
SGTC_5571315-011016.2 µM6833801
SGTC_560957-036583.25 µM6752360
SGTC_6051315-0399119 µM24020461
SGTC_624k048-005228 µM6835531
SGTC_6320781-23534.65 µM6811515
SGTC_6790422-009141.4 µM627384
SGTC_6841140-0066328 µM6813534
SGTC_710417-175047.81 µM6811472
SGTC_7171532-024673.2 µM9561992
SGTC_7360958-025492.6 µM6812352
SGTC_7571066-0008322 µM6842497
SGTC_7771315-0167517 µM4221767
SGTC_8550428-002025 µM6812414
SGTC_910417-175158.38 µM6795624
SGTC_980074-0023107.66 µM3563821
SGTC_9994022-006622.7 µM740511

heat shock/prefoldin responses associated with the prefoldin complex, induced by heat shock 5
heme biosynthesis & mitochondrial translocase heme biosynthesis and the mitchondrial outer membrane translocase complex 19
heme requiring responses associated with heme biosynthesis, induced by compounds such as the iron chelator bathophenantroline 14
iron homeostasis responses associated with iron homeostasis, induced by several iron chelators 35
mitochondrial processes responses associated with mitochondrial processes including ATPase inhibition 53
mitochondrial response to ROS responses associated with mitochondrial genome maintenance, induced by compounds such as the antioxidant mangostin, which may participate in redox cycling 16
mitochondrial stress disruption of mitochondrial processes, associated with charged and reactive compounds 10
NEO1 notable drug-induced haploinsufficiency of NEO1, an aminophospholipid plasma membrane flippase 21
NEO1-PIK1 drug-induced haploinsufficiency of NEO1 (aminophospholipid plasma membrane flippase) and PIK1 (phosphatidylinositol 4-kinase) 17
PDR1 notable requirement for PDR1, a transcription factor that regulates the pleiotropic drug response; no other signature genes 26
plasma membrane duress piperazine-induced plasma membrane duress 18
redox potentiating protein catabolism via the multivesicular body sorting pathway associated with the generation of superoxide 27
RNA pol III & RNase P/MRP responses associated with RNA polymerase III and other complexes 17
RNA processing & uracil transport strong requirement for FUR4, a uracil transporter, and RNA processing genes GLC7 and RRP45; no other signature genes 29
RPP1 & pyrimidine depletion notable drug-induced haploinsufficiency of RPP1, a member of RNase P and MRP, complexes that cleave rRNA and tRNA precursors, respectively 85
RSC & ERG11 RSC chromatin structure remodeling complex and ERG11, an ergosterol biosynthesis enzyme 16
RSC complex & mRNA processing RSC chromatin structure remodeling complex and mRNA processing 24
sphingolipid biosynthesis & PDR1 responses associated with sphingolipid biosynthesis and PDR1, a transcription factor that regulates the pleiotropic drug response (induced by surfactants) 14
superoxide pentose phosphate pathway/NADP metabolism 13
SWF1 & branched chain AA biosynthesis branched chain amino acid biosynthesis and protein modification via SWF1 9
translation cytoplasmic and mitochondrial translation 6
TRP & mitochondrial translation thiazolidinone targeting of protein prenylation (RER2) dirupts mitochondrial function 14
TSC3-RPN4 responses associated with a strong requirement for TSC3 (activator of sphingolipid biosynthesis) and a moderate requirement for RPN4 (transcription factor that stimulates expression of proteasome genes) 59
tubulin folding & SWR complex tubulin biogenesis, induced by tubulin inhibitors benomyl and nocodazole 26
ubiquinone biosynthesis & proteasome responses associated with the 20S proteosome, ubiquinone biosynthesis and an adamantyl structure moiety 18
unfolded protein response unfolded protein response induced by inhibition of diverse HIP targets 11