Major Responses

The major response signatures can be explored in detail in the network of response signatures (i.e. a web version of fig. 2).
GO TO network of response signatures

Major response signatures and their associated screens are indicated below (click on arrow to view screens).

Response SignatureDescriptionNumber
60S ribosome export LSG1-NMD3 mediated ribosomal export from the nucleus 102
amide catabolism responses associated with DAL81, a nitrogen catabolite activator 32
anthracycline transcription coupled DNA repair responses associated with SSL2, a member of RNA polymerase transcription factor TFIIH holoenzyme, and DNA damage 7
azole & statin sterol biosynthesis, induced by ergosterol pathway inhibitors such as azoles and statins 26
calcium & mitochondrial duress calcium stress response, includes IMP2', a transcriptional activator involved in ion homeostasis 38
cell wall regulation of cell wall organization 31
cell wall signaling protein kinase C signaling 25
copper-dependent oxidative stress copper transport induced by oxidative stress and copper-dependent SOD1, SOD2 25
DNA damage response DNA damage and repair 34
DNA intercalators responses associated with ERG12 (ergosterol biosynthesis), YMR166C (potential mitochondrial carrier), EFM1 (lysine methyltransferase of eIF1A) and CEP3 (kineticore protein) 27
endomembrane recycling responses associated with RCY1, a protein involved in recycling plasma membrane proteins, and (amino)phospholipid transport 31
ERAD & cell cycle endoplasmic reticulum-associated degradation and cell cycle 11
ERG2 responses associated with ERG2, involved in ergosterol biosynthesis; deletion increases membrane permeability; no other signature genes 49
ergosterol biosynthesis ergosterol biosynthesis 20
ergosterol depletion effects on membrane effects of high concentrations of ergosterol inhibitors on plasma membrane (e.g. vesicular trafficking, sterol biosynthesis) and regulation of GTPase activity 15
excess fatty acid response to excess fatty acid, primarily through LRO1, an acyltransferase that catalyzes diacylglycerol esterification 9
exosome exosome complex; induced by uracil analogs such as 5-fluorouracil 7
fatty acid desaturase (OLE1) responses associated with drug-induced happloinsufficiency of OLE1 (fatty acid desaturase) 36
Golgi intra-Golgi transport involving the COG1-8 Golgi transport complex 71
heat shock/prefoldin responses associated with the prefoldin complex, induced by heat shock 5
heme biosynthesis & mitochondrial translocase heme biosynthesis and the mitchondrial outer membrane translocase complex 19
heme requiring responses associated with heme biosynthesis, induced by compounds such as the iron chelator bathophenantroline 14
iron homeostasis responses associated with iron homeostasis, induced by several iron chelators 35
mitochondrial processes responses associated with mitochondrial processes including ATPase inhibition 53
mitochondrial response to ROS responses associated with mitochondrial genome maintenance, induced by compounds such as the antioxidant mangostin, which may participate in redox cycling 16
mitochondrial stress disruption of mitochondrial processes, associated with charged and reactive compounds 10
NEO1 notable drug-induced haploinsufficiency of NEO1, an aminophospholipid plasma membrane flippase 21
NEO1-PIK1 drug-induced haploinsufficiency of NEO1 (aminophospholipid plasma membrane flippase) and PIK1 (phosphatidylinositol 4-kinase) 17
PDR1 notable requirement for PDR1, a transcription factor that regulates the pleiotropic drug response; no other signature genes 26
plasma membrane duress piperazine-induced plasma membrane duress 18
redox potentiating protein catabolism via the multivesicular body sorting pathway associated with the generation of superoxide 27
RNA pol III & RNase P/MRP responses associated with RNA polymerase III and other complexes 17
RNA processing & uracil transport strong requirement for FUR4, a uracil transporter, and RNA processing genes GLC7 and RRP45; no other signature genes 29
RPP1 & pyrimidine depletion notable drug-induced haploinsufficiency of RPP1, a member of RNase P and MRP, complexes that cleave rRNA and tRNA precursors, respectively 85
RSC & ERG11 RSC chromatin structure remodeling complex and ERG11, an ergosterol biosynthesis enzyme 16
RSC complex & mRNA processing RSC chromatin structure remodeling complex and mRNA processing 24
sphingolipid biosynthesis & PDR1 responses associated with sphingolipid biosynthesis and PDR1, a transcription factor that regulates the pleiotropic drug response (induced by surfactants) 14
superoxide pentose phosphate pathway/NADP metabolism 13
SWF1 & branched chain AA biosynthesis branched chain amino acid biosynthesis and protein modification via SWF1 9
translation cytoplasmic and mitochondrial translation 6
TRP & mitochondrial translation thiazolidinone targeting of protein prenylation (RER2) dirupts mitochondrial function 14
TSC3-RPN4 responses associated with a strong requirement for TSC3 (activator of sphingolipid biosynthesis) and a moderate requirement for RPN4 (transcription factor that stimulates expression of proteasome genes) 59
Screen IDConditionsConcentrationPubchem CID
SGTC_10134112-3890241 µM705171
SGTC_10234482-388816 µM3303168
SGTC_10244507-039526 µM4201836
SGTC_1030k029-004236.7 µM6080581
SGTC_10420350-009682 µM3122515
SGTC_1080nisoldipine24.4 µM4499
SGTC_1119parthenolide318.54 nM5702252
SGTC_11730443-0020122 µM5331295
SGTC_12220366-00741.18 µM286520
SGTC_12991079-14393.74 µM323161
SGTC_13321480-065317.5 µM5749438
SGTC_1603st00204567.8 µM5887985
SGTC_1604st00205272.4 µM6254834
SGTC_1634st00657641 µM3915356
SGTC_1662st01405452 µM2838777
SGTC_1685st02404953.09 µM1941139
SGTC_1706st0313219.97 µM6103185
SGTC_1738st03555574 µM5331140
SGTC_1795st04954562.3 µM5291882
SGTC_1813st0512468.6 µM5291959
SGTC_1815st05165558.2 µM5984156
SGTC_1845st0567533.01 µM5375839
SGTC_18584-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione62.6 µM756377
SGTC_1891st05907326.2 µM688754
SGTC_1919st06711352.3 µM1268243
SGTC_1925st05777010.1 µM5989122
SGTC_1970st07012235.8 µM102928
SGTC_1978st07176142 µM5147680
SGTC_2071523095139.92 µM1799272
SGTC_20905301565104.45 µM2056344
SGTC_2092530369480.67 µM1963699
SGTC_21105483698200 µM2848765
SGTC_21125488546200 µM600757
SGTC_21135491891107.03 µM789979
SGTC_2217693479996.07 µM675606
SGTC_22186965428192.98 µM675684
SGTC_2350330-00875 mM46494818
SGTC_2552juarezic acid87.02 µM1549512
SGTC_2592piperlongumine83.33 µM637858
SGTC_2627acetyl isogambogic acid100 µM6857789
SGTC_28pentachloropyridine N-oxide1.61 µM140250
SGTC_294990725422.23 µM16457352
SGTC_320928-014234.1 µM2244242
SGTC_3236913270149.47 µM24282524
SGTC_328k915-012063.5 µM6624543
SGTC_4283448-415316.5 µM3834874
SGTC_470149-013524.25 µM5239155
SGTC_503tyrphostin 8294 µM92970
SGTC_520329-0193875 nM3739292
SGTC_5481436-0017110 µM9677137
SGTC_5504123-038525.7 µM5731123
SGTC_720r052-164449.9 µM1422863
SGTC_7521896-0090130 µM772567
SGTC_7621165-0429115 µM5967793
SGTC_770828-028612.52 µM745345
SGTC_7901575-001279.1 µM378741
SGTC_8850865-010616.8 µM2793380
SGTC_9262268-140159.4 µM2931578
SGTC_9851493-03078.71 µM3278274

tubulin folding & SWR complex tubulin biogenesis, induced by tubulin inhibitors benomyl and nocodazole 26
ubiquinone biosynthesis & proteasome responses associated with the 20S proteosome, ubiquinone biosynthesis and an adamantyl structure moiety 18
unfolded protein response unfolded protein response induced by inhibition of diverse HIP targets 11