Hip-Hop Chemical Genomics Lab-Publications

     For more recent publications:

   [ All | Giaever | Nislow ]

2013

Lis M., Bhatt S., Schoenly N., Lee A., Nislow C., Bobek L.  Chemical Genomic Screening of a Saccharomyces cerevisiae Genomewide Mutant Collection Reveals Genes Required for Defense against Four Antimicrobial Peptides Derived from Proteins Found in Human Saliva. Antimicrob Agents Chemother. 2013 Feb. 57(2)840-7.
    PubMed
Sukhai M., Prabha S., Hurren R., Rutledge A., Lee A., Sriskanthadevan S., Sun H., Wang X., Skrtic M., Seneviratne A.et al. Lysosomal disruption preferentially targets acute myeloid leukemia cells and progenitors. J Clin Invest. 2013 Jan 2. 123(1)315-28.
    PubMed
Tomson B., Crisucci E., Heisler L., Gebbia M., Nislow C., Arndt K.  Effects of the Paf1 complex and histone modifications on snoRNA 3'-end formation reveal broad and locus-specific regulation. Mol Cell Biol. 2013 Jan. 33(1)170-82.
    PubMed

2012

Alfred S., Surendra A., Le C., Lin K., Mok A., Wallace I., Proctor M., Urbanus M., Giaever G., Nislow C.  A phenotypic screening platform to identify small molecule modulators of Chlamydomonas reinhardtii growth, motility and photosynthesis. Genome Biol. 2012 Nov 18. 13(11)R105.
    PubMed
Cheung-Ong K., Song K., Ma Z., Shabtai D., Lee A., Gallo D., Heisler L., Brown G., Bierbach U., Giaever G., Nislow C.  Comparative chemogenomics to examine the mechanism of action of dna-targeted platinum-acridine anticancer agents. ACS Chem Biol. 2012 Nov 16. 7(11)1892-901.
    PubMed
Xu M., Soloveychik M., Ranger M., Schertzberg M., Shah Z., Raisner R., Venkatasubrahmanyan S., Tsui K., Gebbia M., Hughes T., van Bakel H., Nislow C., Madhani H., Meneghini M.  Timing of transcriptional quiescence during gametogenesis is controlled by global histone H3K4 demethylation. Dev Cell. 2012 Nov 13. 23(5)1059-71.
    PubMed
Douglas A., Smith A., Sharifpoor S., Yan Z., Durbic T., Heisler L., Lee A., Ryan O., Göttert H., Surendra A., van Dyk D., Giaever G., Boone C., Nislow C., Andrews B.  Functional analysis with a barcoder yeast gene overexpression system. G3 (Bethesda). 2012 Oct. 2(10)1279-89.
    PubMed
Singh-Babak S., Shekhar T., Smith A., Giaever G., Nislow C., Cowen L.  A novel calcineurin-independent activity of cyclosporin A in Saccharomyces cerevisiae. Mol Biosyst. 2012 Oct. 8(10)2575-84.
    PubMed
Shabtai D., Giaever G., Nislow C.  An algorithm for chemical genomic profiling that minimizes batch effects: Bucket evaluations. BMC Bioinformatics. 2012 Sep 25. 13(1)245.
    PubMed
Ryan O., Shapiro R., Kurat C., Mayhew D., Baryshnikova A., Chin B., Lin Z., Cox M., Vizeacoumar F., Cheung D.et al. Global gene deletion analysis exploring yeast filamentous growth. Science. 2012 Sep 14. 337(6100)1353-6.
    PubMed
Tkach J., Yimit A., Lee A., Riffle M., Costanzo M., Jaschob D., Hendry J., Ou J., Moffat J., Boone C., Davis T., Nislow C., Brown G.  Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol. 2012 Sep. 14(9)966-76.
    PubMed
Chan J., Vuckovic D., Sleno L., Olsen J., Pogoutse O., Havugimana P., Hewel J., Bajaj N., Wang Y., Musteata M., Nislow C., Emili A.  Target identification by chromatographic co-elution: monitoring of drug-protein interactions without immobilization or chemical derivatization. Mol Cell Proteomics. 2012 Jul. 11(7)M111.
    PubMed
Onodera N., Ryu J., Durbic T., Nislow C., Archibald J., Rohde J.  Genome sequence of Shigella flexneri serotype 5a strain M90T Sm. J Bacteriol. 2012 Jun. 194(11)3022.
    PubMed
Klionsky D., Abdalla F., Abeliovich H., Abraham R., Acevedo-Arozena A., Adeli K., Agholme L., Agnello M., Agostinis P., Aguirre-Ghiso J.et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr. 8(4)445-544.
    PubMed
Roemer T., Davies J., Giaever G., Nislow C.  Bugs, drugs and chemical genomics. Nat Chem Biol. 2012 Jan. 8(1)46-56.
    PubMed
Ammar R., Torti D., Tsui K., Gebbia M., Durbic T., Bader G., Giaever G., Nislow C.  Chromatin is an ancient innovation conserved between Archaea and Eukarya. elife. 2012. 1e00078.
    PubMed
Orij R., Urbanus M., Vizeacoumar F., Giaever G., Boone C., Nislow C., Brul S., Smits G.  Genome-wide analysis of intracellular pH reveals quantitative control of cell division rate by pH(c) in Saccharomyces cerevisiae. Genome Biol. 2012. 13(9)R80.
    PubMed
Smith A., Durbic T., Kittanakom S., Giaever G., Nislow C.  Barcode sequencing for understanding drug-gene interactions. Methods Mol Biol. 2012. 91055-69.
    PubMed
Jaime M., Lopez-Llorca L., Conesa A., Lee A., Proctor M., Heisler L., Gebbia M., Giaever G., Westwood J., Nislow C.  Identification of yeast genes that confer resistance to chitosan oligosaccharide (COS) using chemogenomics. BMC Genomics. 2012. 13267.
    PubMed
Blackman R., Cheung-Ong K., Gebbia M., Proia D., He S., Kepros J., Jonneaux A., Marchetti P., Kluza J., Rao P., Wada Y., Giaever G., Nislow C.  Mitochondrial electron transport is the cellular target of the oncology drug elesclomol. PLoS One. 2012. 7(1)e29798.
    PubMed
Tsui K., Durbic T., Gebbia M., Nislow C.  Genomic approaches for determining nucleosome occupancy in yeast. Methods Mol Biol. 2012. 833389-411.
    PubMed

2011

Kurat C., Lambert J., van Dyk D., Tsui K., van Bakel H., Kaluarachchi S., Friesen H., Kainth P., Nislow C., Figeys D., Fillingham J., Andrews B.  Restriction of histone gene transcription to S phase by phosphorylation of a chromatin boundary protein. Genes Dev. 2011 Dec 1. 25(23)2489-501.
    PubMed
Luciani G., Magomedova L., Puckrin R., Urbanus M., Wallace I., Giaever G., Nislow C., Cummins C., Roy P.  Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans. Nat Chem Biol. 2011 Dec. 7(12)891-3.
    PubMed
Skrtić M., Sriskanthadevan S., Jhas B., Gebbia M., Wang X., Wang Z., Hurren R., Jitkova Y., Gronda M., Maclean N.et al. Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia. Cancer Cell. 2011 Nov 15. 20(5)674-88 [NOTE: the web supplements below contain the raw intensities and fitness defect scores (respectively) associated with the chemogenomic profiles].
    PubMed    Web Supplement    Web Supplement
Berry D., Guan Q., Hose J., Haroon S., Gebbia M., Heisler L., Nislow C., Giaever G., Gasch A.  Multiple means to the same end: the genetic basis of acquired stress resistance in yeast. PLoS Genet. 2011 Nov. 7(11)e1002353.
    PubMed
Minear S., O'Donnell A., Ballew A., Giaever G., Nislow C., Stearns T., Cyert M.  Curcumin inhibits growth of Saccharomyces cerevisiae through iron chelation. Eukaryot Cell. 2011 Nov. 10(11)1574-81.
    PubMed
Tsui K., Dubuis S., Gebbia M., Morse R., Barkai N., Tirosh I., Nislow C.  Evolution of nucleosome occupancy: conservation of global properties and divergence of gene-specific patterns. Mol Cell Biol. 2011 Nov. 31(21)4348-55.
    PubMed
Wallace I., Urbanus M., Luciani G., Burns A., Han M., Wang H., Arora K., Heisler L., Proctor M., St Onge R., Roemer T., Roy P., Cummins C., Bader G., Nislow C., Giaever G.  Compound prioritization methods increase rates of chemical probe discovery in model organisms. Chem Biol. 2011 Oct 28. 18(10)1273-83.
    PubMed
Lissina E., Young B., Urbanus M., Guan X., Lowenson J., Hoon S., Baryshnikova A., Riezman I., Michaut M., Riezman H., Cowen L., Wenk M., Clarke S., Giaever G., Nislow C.  A systems biology approach reveals the role of a novel methyltransferase in response to chemical stress and lipid homeostasis. PLoS Genet. 2011 Oct. 7(10)e1002332.
    PubMed
Bendaha H., Yu L., Touzani R., Souane R., Giaever G., Nislow C., Boone C., El Kadiri S., Brown G., Bellaoui M.  New azole antifungal agents with novel modes of action: synthesis and biological studies of new tridentate ligands based on pyrazole and triazole. Eur J Med Chem. 2011 Sep. 46(9)4117-24.
    PubMed
Hoon S., Gebbia M., Costanzo M., Davis R., Giaever G., Nislow C.  A global perspective of the genetic basis for carbonyl stress resistance. G3 (Bethesda). 2011 Aug. 1(3)219-31.
    PubMed
Magtanong L., Ho C., Barker S., Jiao W., Baryshnikova A., Bahr S., Smith A., Heisler L., Choy J., Kuzmin E.et al. Dosage suppression genetic interaction networks enhance functional wiring diagrams of the cell. Nat Biotechnol. 2011 Jun. 29(6)505-11.
    PubMed
Tamble C., St Onge R., Giaever G., Nislow C., Williams A., Stuart J., Lokey R.  The synthetic genetic interaction network reveals small molecules that target specific pathways in Sacchromyces cerevisiae. Mol Biosyst. 2011 Jun. 7(6)2019-30.
    PubMed
Gkikopoulos T., Singh V., Tsui K., Awad S., Renshaw M., Scholfield P., Barton G., Nislow C., Tanaka T., Owen-Hughes T.  The SWI/SNF complex acts to constrain distribution of the centromeric histone variant Cse4. EMBO J. 2011 May 18. 30(10)1919-27.
    PubMed
Li Z., Vizeacoumar F., Bahr S., Li J., Warringer J., Vizeacoumar F., Min R., Vandersluis B., Bellay J., Devit M.et al. Systematic exploration of essential yeast gene function with temperature-sensitive mutants. Nat Biotechnol. 2011 Apr. 29(4)361-7.
    PubMed
Ganapathi M., Palumbo M., Ansari S., He Q., Tsui K., Nislow C., Morse R.  Extensive role of the general regulatory factors, Abf1 and Rap1, in determining genome-wide chromatin structure in budding yeast. Nucleic Acids Res. 2011 Mar. 39(6)2032-44.
    PubMed
Suzuki Y., St Onge R., Mani R., King O., Heilbut A., Labunskyy V., Chen W., Pham L., Zhang L., Tong A., Nislow C., Giaever G., Gladyshev V., Vidal M., Schow P., Lehár J., Roth F.  Knocking out multigene redundancies via cycles of sexual assortment and fluorescence selection. Nat Methods. 2011 Feb. 8(2)159-64.
    PubMed
Cokol M., Chua H., Tasan M., Mutlu B., Weinstein Z., Suzuki Y., Nergiz M., Costanzo M., Baryshnikova A., Giaever G., Nislow C., Myers C., Andrews B., Boone C., Roth F.  Systematic exploration of synergistic drug pairs. Mol Syst Biol. 2011. 7544.
    PubMed
Guan Y., Yao V., Tsui K., Gebbia M., Dunham M., Nislow C., Troyanskaya O.  Nucleosome-coupled expression differences in closely-related species. BMC Genomics. 2011. 12466.
    PubMed
Wallace I., Bader G., Giaever G., Nislow C.  Displaying chemical information on a biological network using Cytoscape. Methods Mol Biol. 2011. 781363-76.
    PubMed
Proctor M., Urbanus M., Fung E., Jaramillo D., Davis R., Nislow C., Giaever G.  The automated cell: compound and environment screening system (ACCESS) for chemogenomic screening. Methods Mol Biol. 2011. 759239-69.
    PubMed
Smith A., Durbic T., Oh J., Urbanus M., Proctor M., Heisler L., Giaever G., Nislow C.  Competitive genomic screens of barcoded yeast libraries. J Vis Exp. 2011. (54).
    PubMed
Oh J., Nislow C.  Signature-tagged mutagenesis to characterize genes through competitive selection of bar-coded genome libraries. Methods Mol Biol. 2011. 765225-52.
    PubMed
Klein M., Morillas M., Vendrell A., Brive L., Gebbia M., Wallace I., Giaever G., Nislow C., Posas F., Grřtli M.  Design, synthesis and characterization of a highly effective inhibitor for analog-sensitive (as) kinases. PLoS One. 2011. 6(6)e20789.
    PubMed
Dinér P., Veide Vilg J., Kjellén J., Migdal I., Andersson T., Gebbia M., Giaever G., Nislow C., Hohmann S., Wysocki R., Tamás M., Grřtli M.  Design, synthesis, and characterization of a highly effective Hog1 inhibitor: a powerful tool for analyzing MAP kinase signaling in yeast. PLoS One. 2011. 6(5)e20012.
    PubMed
Ketela T., Heisler L., Brown K., Ammar R., Kasimer D., Surendra A., Ericson E., Blakely K., Karamboulas D., Smith A.et al. A comprehensive platform for highly multiplexed mammalian functional genetic screens. BMC Genomics. 2011. 12213.
    PubMed

2010

Longo V., Nislow C., Fabrizio P.  Endosomal protein sorting and autophagy genes contribute to the regulation of yeast life span. Autophagy. 2010 Nov. 6(8)1227-8.
    PubMed
Berbenetz N., Nislow C., Brown G.  Diversity of eukaryotic DNA replication origins revealed by genome-wide analysis of chromatin structure. PLoS Genet. 2010 Sep. 6(9).
    PubMed
Smith A., Ammar R., Nislow C., Giaever G.  A survey of yeast genomic assays for drug and target discovery. Pharmacol Ther. 2010 Aug. 127(2)156-64.
    PubMed
Oh J., Fung E., Price M., Dehal P., Davis R., Giaever G., Nislow C., Arkin A., Deutschbauer A.  A universal TagModule collection for parallel genetic analysis of microorganisms. Nucleic Acids Res. 2010 Aug. 38(14)e146.
    PubMed
Fabrizio P., Hoon S., Shamalnasab M., Galbani A., Wei M., Giaever G., Nislow C., Longo V.  Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation. PLoS Genet. 2010 Jul. 6(7)e1001024.
    PubMed
Burns A., Wallace I., Wildenhain J., Tyers M., Giaever G., Bader G., Nislow C., Cutler S., Roy P.  A predictive model for drug bioaccumulation and bioactivity in Caenorhabditis elegans. Nat Chem Biol. 2010 Jul. 6(7)549-57.
    PubMed
Smith A., Heisler L., St Onge R., Farias-Hesson E., Wallace I., Bodeau J., Harris A., Perry K., Giaever G., Pourmand N., Nislow C.  Highly-multiplexed barcode sequencing: an efficient method for parallel analysis of pooled samples. Nucleic Acids Res. 2010 Jul. 38(13)e142.
    PubMed
van Bakel H., Nislow C., Blencowe B., Hughes T.  Most "dark matter" transcripts are associated with known genes. PLoS Biol. 2010 May. 8(5)e1000371.
    PubMed
Dowell R., Ryan O., Jansen A., Cheung D., Agarwala S., Danford T., Bernstein D., Rolfe P., Heisler L., Chin B., Nislow C., Giaever G., Phillips P., Fink G., Gifford D., Boone C.  Genotype to phenotype: a complex problem. Science. 2010 Apr 23. 328(5977)469.
    PubMed
Chan J., Nislow C., Emili A.  Recent advances and method development for drug target identification. Trends Pharmacol Sci. 2010 Feb. 31(2)82-8.
    PubMed
Costanzo M., Baryshnikova A., Bellay J., Kim Y., Spear E., Sevier C., Ding H., Koh J., Toufighi K., Mostafavi S.et al. The genetic landscape of a cell. Science. 2010 Jan 22. 327(5964)425-31.
    PubMed
Vizeacoumar F., van Dyk N., S Vizeacoumar F., Cheung V., Li J., Sydorskyy Y., Case N., Li Z., Datti A., Nislow C., Raught B., Zhang Z., Frey B., Bloom K., Boone C., Andrews B.  Integrating high-throughput genetic interaction mapping and high-content screening to explore yeast spindle morphogenesis. J Cell Biol. 2010 Jan 11. 188(1)69-81.
    PubMed
Oh J., Fung E., Schlecht U., Davis R., Giaever G., St Onge R., Deutschbauer A., Nislow C.  Gene annotation and drug target discovery in Candida albicans with a tagged transposon mutant collection. PLoS Pathog. 2010. 6(10)e1001140.
    PubMed
Ericson E., Hoon S., St Onge R., Giaever G., Nislow C.  Exploring gene function and drug action using chemogenomic dosage assays. Methods Enzymol. 2010. 470233-55.
    PubMed
Hillenmeyer M., Ericson E., Davis R., Nislow C., Koller D., Giaever G.  Systematic analysis of genome-wide fitness data in yeast reveals novel gene function and drug action. Genome Biol. 2010. 11(3)R30.
    PubMed

2009

Costanzo M., Baryshnikova A., Nislow C., Andrews B., Boone C.  You too can play with an edge. Nat Methods. 2009 Nov. 6(11)797-8.
    PubMed
Smith A., Heisler L., Mellor J., Kaper F., Thompson M., Chee M., Roth F., Giaever G., Nislow C.  Quantitative phenotyping via deep barcode sequencing. Genome Res. 2009 Oct. 19(10)1836-42.
    PubMed
Juneau K., Nislow C., Davis R.  Alternative splicing of PTC7 in Saccharomyces cerevisiae determines protein localization. Genetics. 2009 Sep. 183(1)185-94.
    PubMed
Fillingham J., Kainth P., Lambert J., van Bakel H., Tsui K., Peńa-Castillo L., Nislow C., Figeys D., Hughes T., Greenblatt J., Andrews B.  Two-color cell array screen reveals interdependent roles for histone chaperones and a chromatin boundary regulator in histone gene repression. Mol Cell. 2009 Aug 14. 35(3)340-51.
    PubMed
Yan Z., Berbenetz N., Giaever G., Nislow C.  Precise gene-dose alleles for chemical genetics. Genetics. 2009 Jun. 182(2)623-6.
    PubMed
Nislow C.  Self-reporting cells. Biotechniques. 2009 Apr. 46(5)356-7.
    PubMed
Ho C., Magtanong L., Barker S., Gresham D., Nishimura S., Natarajan P., Koh J., Porter J., Gray C., Andersen R., Giaever G., Nislow C., Andrews B., Botstein D., Graham T., Yoshida M., Boone C.  A molecular barcoded yeast ORF library enables mode-of-action analysis of bioactive compounds. Nat Biotechnol. 2009 Apr. 27(4)369-77.
    PubMed
Hess D., Myers C., Huttenhower C., Hibbs M., Hayes A., Paw J., Clore J., Mendoza R., Luis B., Nislow C., Giaever G., Costanzo M., Troyanskaya O., Caudy A.  Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis. PLoS Genet. 2009 Mar. 5(3)e1000407.
    PubMed
Giaever G., Nislow C.  Knocking sense into regulatory pathways. Nat Biotechnol. 2009 Feb. 27(2)149-50.
    PubMed
Ammar R., Smith A., Heisler L., Giaever G., Nislow C.  A comparative analysis of DNA barcode microarray feature size. BMC Genomics. 2009. 10471.
    PubMed
Pierce S., Davis R., Nislow C., Giaever G.  Chemogenomic approaches to elucidation of gene function and genetic pathways. Methods Mol Biol. 2009. 548115-43.
    PubMed
Jo W., Kim J., Oh E., Jaramillo D., Holman P., Loguinov A., Arkin A., Nislow C., Giaever G., Vulpe C.  Novel insights into iron metabolism by integrating deletome and transcriptome analysis in an iron deficiency model of the yeast Saccharomyces cerevisiae. BMC Genomics. 2009. 10130.
    PubMed
Kemmer D., McHardy L., Hoon S., Rebérioux D., Giaever G., Nislow C., Roskelley C., Roberge M.  Combining chemical genomics screens in yeast to reveal spectrum of effects of chemical inhibition of sphingolipid biosynthesis. BMC Microbiol. 2009. 99.
    PubMed

2008

Badis G., Chan E., van Bakel H., Pena-Castillo L., Tillo D., Tsui K., Carlson C., Gossett A., Hasinoff M., Warren C.et al. A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Mol Cell. 2008 Dec 26. 32(6)878-87.
    PubMed
Yu L., Lopez A., Anaflous A., El Bali B., Hamal A., Ericson E., Heisler L., McQuibban A., Giaever G., Nislow C., Boone C., Brown G., Bellaoui M.  Chemical-genetic profiling of imidazo[1,2-a]pyridines and -pyrimidines reveals target pathways conserved between yeast and human cells. PLoS Genet. 2008 Nov. 4(11)e1000284.
    PubMed
Lehár J., Stockwell B., Giaever G., Nislow C.  Combination chemical genetics. Nat Chem Biol. 2008 Nov. 4(11)674-81.
    PubMed
Hoon S., St Onge R., Giaever G., Nislow C.  Yeast chemical genomics and drug discovery: an update. Trends Pharmacol Sci. 2008 Oct. 29(10)499-504.
    PubMed
Yan Z., Costanzo M., Heisler L., Paw J., Kaper F., Andrews B., Boone C., Giaever G., Nislow C.  Yeast Barcoders: a chemogenomic application of a universal donor-strain collection carrying bar-code identifiers. Nat Methods. 2008 Aug. 5(8)719-25.
    PubMed
Hoon S., Smith A., Wallace I., Suresh S., Miranda M., Fung E., Proctor M., Shokat K., Zhang C., Davis R., Giaever G., St Onge R., StOnge R., Nislow C.  An integrated platform of genomic assays reveals small-molecule bioactivities. Nat Chem Biol. 2008 Aug. 4(8)498-506.
    PubMed
Musso G., Costanzo M., Huangfu M., Smith A., Paw J., San Luis B., Boone C., Giaever G., Nislow C., Emili A., Zhang Z.  The extensive and condition-dependent nature of epistasis among whole-genome duplicates in yeast. Genome Res. 2008 Jul. 18(7)1092-9.
    PubMed
Hillenmeyer M., Fung E., Wildenhain J., Pierce S., Hoon S., Lee W., Proctor M., St Onge R., Tyers M., Koller D., Altman R., Davis R., Nislow C., Giaever G.  The chemical genomic portrait of yeast: uncovering a phenotype for all genes. Science. 2008 Apr 18. 320(5874)362-5.
    PubMed
Mani R., St Onge R., Hartman J., Giaever G., Roth F.  Defining genetic interaction. Proc Natl Acad Sci U S A. 2008 Mar 4. 105(9)3461-6.
    PubMed
Arnoldo A., Curak J., Kittanakom S., Chevelev I., Lee V., Sahebol-Amri M., Koscik B., Ljuma L., Roy P., Bedalov A., Giaever G., Nislow C., Merrill A., Merrill R., Lory S., Stagljar I.  Identification of small molecule inhibitors of Pseudomonas aeruginosa exoenzyme S using a yeast phenotypic screen. PLoS Genet. 2008 Feb. 4(2)e1000005.
    PubMed
Jo W., Loguinov A., Chang M., Wintz H., Nislow C., Arkin A., Giaever G., Vulpe C.  Identification of genes involved in the toxic response of Saccharomyces cerevisiae against iron and copper overload by parallel analysis of deletion mutants. Toxicol Sci. 2008 Jan. 101(1)140-51.
    PubMed
Ericson E., Gebbia M., Heisler L., Wildenhain J., Tyers M., Giaever G., Nislow C.  Off-target effects of psychoactive drugs revealed by genome-wide assays in yeast. PLoS Genet. 2008. 4(8)e1000151.
    PubMed
Lopez A., Parsons A., Nislow C., Giaever G., Boone C.  Chemical-genetic approaches for exploring the mode of action of natural products. Prog Drug Res. 2008. 66237, 239-71.
    PubMed

2007

Suter B., Fetchko M., Imhof R., Graham C., Stoffel-Studer I., Zbinden C., Raghavan M., Lopez L., Beneti L., Hort J., Fillingham J., Greenblatt J., Giaever G., Nislow C., Stagljar I.  Examining protein protein interactions using endogenously tagged yeast arrays: the cross-and-capture system. Genome Res. 2007 Dec. 17(12)1774-82.
    PubMed
Lee W., Tillo D., Bray N., Morse R., Davis R., Hughes T., Nislow C.  A high-resolution atlas of nucleosome occupancy in yeast. Nat Genet. 2007 Oct. 39(10)1235-44.
    PubMed
Gassner N., Tamble C., Bock J., Cotton N., White K., Tenney K., St Onge R., Proctor M., Giaever G., Nislow C., Davis R., Crews P., Holman T., Lokey R.  Accelerating the discovery of biologically active small molecules using a high-throughput yeast halo assay. J Nat Prod. 2007 Mar. 70(3)383-90.
    PubMed
St Onge R., Mani R., Oh J., Proctor M., Fung E., Davis R., Nislow C., Roth F., Giaever G.  Systematic pathway analysis using high-resolution fitness profiling of combinatorial gene deletions. Nat Genet. 2007 Feb. 39(2)199-206.
    PubMed
Doostzadeh J., Davis R., Giaever G., Nislow C., Langston J.  Chemical genomic profiling for identifying intracellular targets of toxicants producing Parkinson's disease. Toxicol Sci. 2007 Jan. 95(1)182-7.
    PubMed
Pierce S., Davis R., Nislow C., Giaever G.  Genome-wide analysis of barcoded Saccharomyces cerevisiae gene-deletion mutants in pooled cultures. Nat Protoc. 2007. 2(11)2958-74.
    PubMed

2006

Costanzo M., Giaever G., Nislow C., Andrews B.  Experimental approaches to identify genetic networks. Curr Opin Biotechnol. 2006 Oct. 17(5)472-80.
    PubMed
Juneau K., Miranda M., Hillenmeyer M., Nislow C., Davis R.  Introns regulate RNA and protein abundance in yeast. Genetics. 2006 Sep. 174(1)511-8.
    PubMed
Pierce S., Fung E., Jaramillo D., Chu A., Davis R., Nislow C., Giaever G.  A unique and universal molecular barcode array. Nat Methods. 2006 Aug. 3(8)601-3.
    PubMed

2005

Flaherty P., Giaever G., Kumm J., Jordan M., Arkin A.  A latent variable model for chemogenomic profiling. Bioinformatics. 2005 Aug 1. 21(15)3286-93.
    PubMed
Lee W., St Onge R., Proctor M., Flaherty P., Jordan M., Arkin A., Davis R., Nislow C., Giaever G.  Genome-wide requirements for resistance to functionally distinct DNA-damaging agents. PLoS Genet. 2005 Aug. 1(2)e24.
    PubMed
Wall D., Hirsh A., Fraser H., Kumm J., Giaever G., Eisen M., Feldman M.  Functional genomic analysis of the rates of protein evolution. Proc Natl Acad Sci U S A. 2005 Apr 12. 102(15)5483-8.
    PubMed
Deutschbauer A., Jaramillo D., Proctor M., Kumm J., Hillenmeyer M., Davis R., Nislow C., Giaever G.  Mechanisms of haploinsufficiency revealed by genome-wide profiling in yeast. Genetics. 2005 Apr. 169(4)1915-25.
    PubMed

2004

Fraser H., Hirsh A., Giaever G., Kumm J., Eisen M.  Noise minimization in eukaryotic gene expression. PLoS Biol. 2004 Jun. 2(6)e137.
    PubMed
Giaever G., Flaherty P., Kumm J., Proctor M., Nislow C., Jaramillo D., Chu A., Jordan M., Arkin A., Davis R.  Chemogenomic profiling: identifying the functional interactions of small molecules in yeast. Proc Natl Acad Sci U S A. 2004 Jan 20. 101(3)793-8.
    PubMed

2003

Giaever G.  A chemical genomics approach to understanding drug action. Trends Pharmacol Sci. 2003 Sep. 24(9)444-6.
    PubMed
Nislow C., Giaever G.  "Chemogenomics: tools for protein families" and "Chemical genomics: chemical and biological integration". Pharmacogenomics. 2003 Jan. 4(1)15-8.
    PubMed

2002

Steinmetz L., Scharfe C., Deutschbauer A., Mokranjac D., Herman Z., Jones T., Chu A., Giaever G., Prokisch H., Oefner P., Davis R.  Systematic screen for human disease genes in yeast. Nat Genet. 2002 Aug. 31(4)400-4.
    PubMed
Giaever G., Chu A., Ni L., Connelly C., Riles L., Véronneau S., Dow S., Lucau-Danila A., Anderson K., André B.et al. Functional profiling of the Saccharomyces cerevisiae genome. Nature. 2002 Jul 25. 418(6896)387-91.
    PubMed
Birrell G., Brown J., Wu H., Giaever G., Chu A., Davis R., Brown J.  Transcriptional response of Saccharomyces cerevisiae to DNA-damaging agents does not identify the genes that protect against these agents. Proc Natl Acad Sci U S A. 2002 Jun 25. 99(13)8778-83.
    PubMed

2001

Birrell G., Giaever G., Chu A., Davis R., Brown J.  A genome-wide screen in Saccharomyces cerevisiae for genes affecting UV radiation sensitivity. Proc Natl Acad Sci U S A. 2001 Oct 23. 98(22)12608-13.
    PubMed

1999

Winzeler E., Shoemaker D., Astromoff A., Liang H., Anderson K., Andre B., Bangham R., Benito R., Boeke J., Bussey H.et al. Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. Science. 1999 Aug 6. 285(5429)901-6.
    PubMed
Giaever G., Shoemaker D., Jones T., Liang H., Winzeler E., Astromoff A., Davis R.  Genomic profiling of drug sensitivities via induced haploinsufficiency. Nat Genet. 1999 Mar. 21(3)278-83.
    PubMed

1997

Nislow C., Ray E., Pillus L.  SET1, a yeast member of the trithorax family, functions in transcriptional silencing and diverse cellular processes. Mol Biol Cell. 1997 Dec. 8(12)2421-36.
    PubMed
Laible G., Wolf A., Dorn R., Reuter G., Nislow C., Lebersorger A., Popkin D., Pillus L., Jenuwein T.  Mammalian homologues of the Polycomb-group gene Enhancer of zeste mediate gene silencing in Drosophila heterochromatin and at S. cerevisiae telomeres. EMBO J. 1997 Jun 2. 16(11)3219-32.
    PubMed

1995

Lombillo V., Nislow C., Yen T., Gelfand V., McIntosh J.  Antibodies to the kinesin motor domain and CENP-E inhibit microtubule depolymerization-dependent motion of chromosomes in vitro. J Cell Biol. 1995 Jan. 128(1-2)107-15.
    PubMed

1992

Nislow C., Lombillo V., Kuriyama R., McIntosh J.  A plus-end-directed motor enzyme that moves antiparallel microtubules in vitro localizes to the interzone of mitotic spindles. Nature. 1992 Oct 8. 359(6395)543-7.
    PubMed
Kuriyama R., Nislow C.  Molecular components of the mitotic spindle. Bioessays. 1992 Feb. 14(2)81-8.
    PubMed

1991

Klymkowsky M., Maynell L., Nislow C.  Cytokeratin phosphorylation, cytokeratin filament severing and the solubilization of the maternal mRNA Vg1. J Cell Biol. 1991 Aug. 114(4)787-97.
    PubMed

1990

Nislow C., Sellitto C., Kuriyama R., McIntosh J.  A monoclonal antibody to a mitotic microtubule-associated protein blocks mitotic progression. J Cell Biol. 1990 Aug. 111(2)511-22.
    PubMed

1988

Giaever G., Wang J.  Supercoiling of intracellular DNA can occur in eukaryotic cells. Cell. 1988 Dec 2. 55(5)849-56.
    PubMed
Wang J., Giaever G.  Action at a distance along a DNA. Science. 1988 Apr 15. 240(4850)300-4.
    PubMed
Giaever G., Snyder L., Wang J.  DNA supercoiling in vivo. Biophys Chem. 1988 Feb. 29(1-2)7-15.
    PubMed

1986

Giaever G., Lynn R., Goto T., Wang J.  The complete nucleotide sequence of the structural gene TOP2 of yeast DNA topoisomerase II. J Biol Chem. 1986 Sep 25. 261(27)12448-54.
    PubMed
Lynn R., Giaever G., Swanberg S., Wang J.  Tandem regions of yeast DNA topoisomerase II share homology with different subunits of bacterial gyrase. Science. 1986 Aug 8. 233(4764)647-9.
    PubMed