YGL079W_p / KXD1

Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; GFP-fusion protein localizes to the endosome

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL079W / KXD1

Click on Significant Values for Screen Details ID:SGTC_141|Compound:0443-0274|FD-Score:-2.98|P-value:7.33E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:4.64|P-value:3.81E-7 ID:SGTC_528|Compound:3492-0019|FD-Score:3.10|P-value:4.81E-4 ID:SGTC_556|Compound:4058-0063|FD-Score:4.00|P-value:1.02E-5 ID:SGTC_678|Compound:1218-2179|FD-Score:3.31|P-value:2.05E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:3.46|P-value:1.11E-4 ID:SGTC_826|Compound:1683-5028|FD-Score:-3.18|P-value:3.34E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:2.91|P-value:9.55E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.11|P-value:4.44E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:-3.44|P-value:1.19E-4 ID:SGTC_1435|Compound:4092-0789|FD-Score:3.16|P-value:3.85E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.78|P-value:2.79E-5 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:4.21|P-value:3.56E-6 ID:SGTC_1712|Compound:st032288|FD-Score:3.07|P-value:5.40E-4 ID:SGTC_1752|Compound:st044819|FD-Score:-2.90|P-value:9.62E-4 ID:SGTC_1934|Compound:st074720|FD-Score:-3.37|P-value:1.60E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.03|P-value:6.30E-4 ID:SGTC_2008|Compound:4012253|FD-Score:3.42|P-value:1.34E-4 ID:SGTC_2021|Compound:4019055|FD-Score:7.99|P-value:7.68E-18 ID:SGTC_2142|Compound:5622915|FD-Score:-3.07|P-value:5.22E-4 ID:SGTC_2319|Compound:6033012|FD-Score:-3.55|P-value:7.50E-5 ID:SGTC_2376|Compound:9072922|FD-Score:-3.16|P-value:3.69E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:-3.14|P-value:3.98E-4 ID:SGTC_2643|Compound:anethole|FD-Score:3.07|P-value:5.33E-4 ID:SGTC_2676|Compound:harmalol|FD-Score:3.35|P-value:1.76E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.77|P-value:2.53E-13 ID:SGTC_2777|Compound:climbazole|FD-Score:2.93|P-value:8.95E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.14|P-value:4.09E-4 ID:SGTC_2786|Compound:7743617|FD-Score:2.98|P-value:7.38E-4 ID:SGTC_2804|Compound:7954240|FD-Score:-4.07|P-value:6.99E-6 ID:SGTC_2812|Compound:7970281|FD-Score:-3.70|P-value:3.87E-5 ID:SGTC_2849|Compound:9019321|FD-Score:3.47|P-value:1.09E-4 ID:SGTC_2862|Compound:9027634|FD-Score:3.05|P-value:5.82E-4 ID:SGTC_2871|Compound:9038510|FD-Score:3.11|P-value:4.66E-4 ID:SGTC_2896|Compound:9052656|FD-Score:4.61|P-value:4.32E-7 ID:SGTC_2989|Compound:9073649|FD-Score:3.01|P-value:6.75E-4 ID:SGTC_3153|Compound:9100258|FD-Score:-3.03|P-value:6.07E-4 ID:SGTC_3204|Compound:9114183|FD-Score:-2.95|P-value:7.97E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-2.98|P-value:7.33E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:4.64|P-value:3.81E-7 ID:SGTC_528|Compound:3492-0019|FD-Score:3.10|P-value:4.81E-4 ID:SGTC_556|Compound:4058-0063|FD-Score:4.00|P-value:1.02E-5 ID:SGTC_678|Compound:1218-2179|FD-Score:3.31|P-value:2.05E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:3.46|P-value:1.11E-4 ID:SGTC_826|Compound:1683-5028|FD-Score:-3.18|P-value:3.34E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:2.91|P-value:9.55E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.11|P-value:4.44E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:-3.44|P-value:1.19E-4 ID:SGTC_1435|Compound:4092-0789|FD-Score:3.16|P-value:3.85E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.78|P-value:2.79E-5 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:4.21|P-value:3.56E-6 ID:SGTC_1712|Compound:st032288|FD-Score:3.07|P-value:5.40E-4 ID:SGTC_1752|Compound:st044819|FD-Score:-2.90|P-value:9.62E-4 ID:SGTC_1934|Compound:st074720|FD-Score:-3.37|P-value:1.60E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.03|P-value:6.30E-4 ID:SGTC_2008|Compound:4012253|FD-Score:3.42|P-value:1.34E-4 ID:SGTC_2021|Compound:4019055|FD-Score:7.99|P-value:7.68E-18 ID:SGTC_2142|Compound:5622915|FD-Score:-3.07|P-value:5.22E-4 ID:SGTC_2319|Compound:6033012|FD-Score:-3.55|P-value:7.50E-5 ID:SGTC_2376|Compound:9072922|FD-Score:-3.16|P-value:3.69E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:-3.14|P-value:3.98E-4 ID:SGTC_2643|Compound:anethole|FD-Score:3.07|P-value:5.33E-4 ID:SGTC_2676|Compound:harmalol|FD-Score:3.35|P-value:1.76E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.77|P-value:2.53E-13 ID:SGTC_2777|Compound:climbazole|FD-Score:2.93|P-value:8.95E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.14|P-value:4.09E-4 ID:SGTC_2786|Compound:7743617|FD-Score:2.98|P-value:7.38E-4 ID:SGTC_2804|Compound:7954240|FD-Score:-4.07|P-value:6.99E-6 ID:SGTC_2812|Compound:7970281|FD-Score:-3.70|P-value:3.87E-5 ID:SGTC_2849|Compound:9019321|FD-Score:3.47|P-value:1.09E-4 ID:SGTC_2862|Compound:9027634|FD-Score:3.05|P-value:5.82E-4 ID:SGTC_2871|Compound:9038510|FD-Score:3.11|P-value:4.66E-4 ID:SGTC_2896|Compound:9052656|FD-Score:4.61|P-value:4.32E-7 ID:SGTC_2989|Compound:9073649|FD-Score:3.01|P-value:6.75E-4 ID:SGTC_3153|Compound:9100258|FD-Score:-3.03|P-value:6.07E-4 ID:SGTC_3204|Compound:9114183|FD-Score:-2.95|P-value:7.97E-4

Top fitness defect scores for YGL079W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2021 4019055 7.99 173.0 µM 7.68E-18 endomembrane recycling 22 6.74E-16
2 SGTC_2688 kanamycin b 6.77 96.7 µM 2.53E-13 calcium & mitochondrial duress 115 6.38E-12
3 SGTC_358 0075-0058 4.64 9.4 µM 3.81E-7 35 1.77E-6
4 SGTC_2896 9052656 4.61 71.4 µM 4.32E-7 endomembrane recycling 78 1.98E-6
5 SGTC_1587 estradiol valerate 4.21 56.1 µM 3.56E-6 8 1.27E-5
6 SGTC_556 4058-0063 4.00 51.5 µM 1.02E-5 24 3.23E-5
7 SGTC_1445 4239-0156 3.78 97.7 µM 2.79E-5 31 7.86E-5
8 SGTC_2849 9019321 3.47 13.0 µM 1.09E-4 47 2.62E-4
9 SGTC_736 0958-0254 3.46 92.6 µM 1.11E-4 Golgi 47 2.67E-4
10 SGTC_2008 4012253 3.42 172.0 µM 1.34E-4 43 3.15E-4
11 SGTC_2676 harmalol 3.35 100.0 µM 1.76E-4 mitochondrial processes 29 4.02E-4
12 SGTC_678 1218-2179 3.31 85.9 µM 2.05E-4 RNA pol III & RNase P/MRP 10 4.60E-4
13 SGTC_1435 4092-0789 3.16 56.7 µM 3.85E-4 plasma membrane duress 40 8.02E-4
14 SGTC_2778 tioconazole 3.14 65.1 nM 4.09E-4 ergosterol depletion effects on membrane 110 8.46E-4
15 SGTC_2871 9038510 3.11 13.0 µM 4.66E-4 50 9.50E-4
16 SGTC_528 3492-0019 3.10 172.0 µM 4.81E-4 calcium & mitochondrial duress 299 9.78E-4
17 SGTC_2643 anethole 3.07 100.0 µM 5.33E-4 47 0.00107
18 SGTC_1712 st032288 3.07 53.4 µM 5.40E-4 calcium & mitochondrial duress 258 0.00108
19 SGTC_2862 9027634 3.05 71.4 µM 5.82E-4 ERG2 67 0.00116
20 SGTC_2002 4023503 3.03 131.0 µM 6.30E-4 mitochondrial processes 87 0.00124

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.292 4.36E-67 YDR467C_d YDR467C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.284 4.06E-63 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.233 2.12E-42 YKL061W_p BLI1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome
0.231 1.04E-41 YDR466W PKH3 hom Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant
0.226 2.92E-40 YEL022W GEA2 hom Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA2 has a paralog, GEA1, that arose from the whole genome duplication
0.221 1.73E-38 YLR408C_p BLS1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome; YLR408C is not an essential gene
0.214 3.24E-36 YDR310C SUM1 hom Transcriptional repressor required for mitotic repression of middle sporulation-specific genes; also acts as general replication initiation factor; involved in telomere maintenance, chromatin silencing; regulated by pachytene checkpoint
0.213 7.79E-36 YDL019C OSH2 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.210 8.45E-35 YBL067C UBP13 hom Putative ubiquitin-specific protease that cleaves Ub-protein fusions; UBP13 has a paralog, UBP9, that arose from the whole genome duplication
0.205 4.31E-33 YGR206W MVB12 hom ESCRT-I subunit required to stabilize oligomers of the ESCRT-I core complex (Stp22p, Vps28p, Srn2p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; deletion mutant is sensitive to rapamycin and nystatin
0.198 6.03E-31 YMR230W-A_p YMR230W-A_p hom Putative protein of unknown function
0.196 2.90E-30 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.187 1.04E-27 YGL203C KEX1 hom Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins
0.184 4.47E-27 YIL105C SLM1 hom Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; protein abundance increases in response to DNA replication stress; SLM1 has a paralog, SLM2, that arose from the whole genome duplication
0.184 5.90E-27 YMR099C YMR099C hom Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS